3D Printing in Pharmaceutical and Medical Applications – Recent Achievements and Challenges

Abstract

Growing demand for customized pharmaceutics and medical devices makes the impact of additive manufacturing increased rapidly in recent years. The 3D printing has become one of the most revolutionary and powerful tool serving as a technology of precise manufacturing of individually developed dosage forms, tissue engineering and disease modeling. The current achievements include multifunctional drug delivery systems with accelerated release characteristic, adjustable and personalized dosage forms, implants and phantoms corresponding to specific patient anatomy as well as cell-based materials for regenerative medicine. This review summarizes the newest achievements and challenges of additive manufacturing in the field of pharmaceutical and biomedical research that have been published since 2015. Currently developed techniques of 3D printing are briefly described while comprehensive analysis of extrusion-based methods as the most intensively investigated is provided. The issue of printlets attributes, i.e. shape and size is described with regard to personalized dosage forms and medical devices manufacturing. The undeniable benefits of 3D printing are highlighted, however a critical view resulting from the limitations and challenges of the additive manufacturing is also included. The regulatory issue is pointed as well.

Improving patient outcomes with regenerative medicine: How the Regenerative Medicine Manufacturing Society plans to move the needle forward in cell manufacturing, standards, 3D bioprinting, artificial intelligence-enabled automation, education, and training

“…3D bioprinting is a platform technology for advancing regenerative medicine manufacturing. 3D bioprinting is envisioned to fabricate multifunctional drug-delivery systems, 16 scaffolds, 17 prosthetics (eg, dental and orthopedic), 18 organoids, 19 tissues, and organs. 20 The use of this technology has grown tremendously in the past 5 years, especially as the cost of devices dropped dramatically, paving the way for more widespread use.…”

How 3D Printing and Social Media Tackles the PPE Shortage during Covid – 19 Pandemic

“…Additive technology used in various sections such as the Aerospace and Automotive industry, military, Sports field, architecture, toys industry and bioengineering with different benefits and disadvantages [16]. Since then, different 3D printing methods have been used, based on extrusion, powder solidification and liquid solidification, with different types of materials as building materials [17].…”

Fabricating large‐scale three‐dimensional constructs with living cells by processing with syringe needles

“…These methods represent easy ways of obtaining cell constructs; however, it is difficult to control the morphology of constructs obtained via these methods. It is also known that cell constructs of arbitrary shapes can be fabricated using micro‐electro mechanical systems (MEMS) or 3D printing . However, these systems require tangled protocols and specific expensive machines.…”

“…It is also known that cell constructs of arbitrary shapes can be fabricated using microelectro mechanical systems (MEMS) 18 or 3D printing. 19,20 Correspondence to: J.-I. Sasaki; e-mail: jun1-s@dent.osaka-u.ac.jp Contract grant sponsor: Grants-in-Aid for Scientific Research, Japan Society for the Promotion of Science (JSPS); contract grant number: 17H04383 and 17K11778 However, these systems require tangled protocols and specific expensive machines.…”