3D printing-mediated microporous starch hydrogels for wound hemostasis

Zheng, Bo; Qiu, Zhipeng; Xu, Jinchuan; Zeng, Xixi; Liu, Kun; Chen, Ling

doi:10.1039/d3tb01189e

Cited by 13 publications

(2 citation statements)

References 42 publications

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“…During wound healing, calcium-containing bioglass has been shown to promote the proliferation, migration, and protein and growth factor expression of endothelial cells and fibroblasts [35]. Calcium ions incorporated microporous hydrogel (illustrated in Figure 4) that could accelerate wound healing through the blood or tissue fluid absorbing on the wound surface due to the hydrogel's characteristics and activating the coagulation cascade with calcium ions released [36].…”

Section: Calcium Ionsmentioning

confidence: 99%

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Clays and Wound Healing

Tian,

Wang,

Huang

et al. 2024

Materials

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Aluminosilicates, such as montmorillonite, kaolinite, halloysite, and diatomite, have a uniform bidimensional structure, a high surface-to-volume ratio, inherent stiffness, a dual charge distribution, chemical inertness, biocompatibility, abundant active groups on the surface, such as silanol (Si-OH) and/or aluminol (Al-OH) groups. These compounds are on the list of U.S. Food and Drug Administration-approved active compounds and excipients and are used for various medicinal products, such as wound healing agents, antidiarrheals, and cosmetics. This review summarizes the wound healing mechanisms related to the material characteristics and the chemical components. Numerous wound dressings with different active components and multiple forms have been studied. Then, medicinal mineral resources for use in hemostatic materials can be developed.

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Section: Calcium Ionsmentioning

confidence: 99%

“…3D-OMS: microporous oxidized maize starch; Ca-OMS: Ca 2+ based oxidized maize starch. Reprinted with permission from ref [36]…”

mentioning

confidence: 99%

Clays and Wound Healing

Tian,

Wang,

Huang

et al. 2024

Materials

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3D Printing‐Based Hydrogel Dressings for Wound Healing

Zhou,

Yu,

You

et al. 2024

Advanced Science

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Skin wounds have become an important issue that affects human health and burdens global medical care. Hydrogel materials similar to the natural extracellular matrix (ECM) are one of the best candidates for ideal wound dressings and the most feasible choices for printing inks. Distinct from hydrogels made by traditional technologies, which lack bionic and mechanical properties, 3D printing can promptly and accurately create hydrogels with complex bioactive structures and the potential to promote tissue regeneration and wound healing. Herein, a comprehensive review of multi‐functional 3D printing‐based hydrogel dressings for wound healing is presented. The review first summarizes the 3D printing techniques for wound hydrogel dressings, including photo‐curing, extrusion, inkjet, and laser‐assisted 3D printing. Then, the properties and design approaches of a series of bioinks composed of natural, synthetic, and composite polymers for 3D printing wound hydrogel dressings are described. Thereafter, the application of multi‐functional 3D printing‐based hydrogel dressings in a variety of wound environments is discussed in depth, including hemostasis, anti‐inflammation, antibacterial, skin appendage regeneration, intelligent monitoring, and machine learning‐assisted therapy. Finally, the challenges and prospects of 3D printing‐based hydrogel dressings for wound healing are presented.

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Preparation and Application of Hemostatic Hydrogels

Zhou,

Lin,

Wang

et al. 2023

Small

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Hemorrhage remains a critical challenge in various medical settings, necessitating the development of advanced hemostatic materials. Hemostatic hydrogels have emerged as promising solutions to address uncontrolled bleeding due to their unique properties, including biocompatibility, tunable physical characteristics, and exceptional hemostatic capabilities. In this review, a comprehensive overview of the preparation and biomedical applications of hemostatic hydrogels is provided. Particularly, hemostatic hydrogels with various materials and forms are introduced. Additionally, the applications of hemostatic hydrogels in trauma management, surgical procedures, wound care, etc. are summarized. Finally, the limitations and future prospects of hemostatic hydrogels are discussed and evaluated. This review aims to highlight the biomedical applications of hydrogels in hemorrhage management and offer insights into the development of clinically relevant hemostatic materials.

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3D printing-mediated microporous starch hydrogels for wound hemostasis

Abstract: Starch hydrogels with biodegradability and cytocompatibility are good alternative to traditional dressings. Herein, oxidized starch hydrogel loaded with coagulation factor Ca2+ ions (CaOMS) is successfully constructed by green hot-extrusion 3D...

Cited by 13 publications

References 42 publications

Clays and Wound Healing

Clays and Wound Healing

3D Printing‐Based Hydrogel Dressings for Wound Healing

Preparation and Application of Hemostatic Hydrogels

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