3D Printing of Cytocompatible Water-Based Light-Cured Polyurethane with Hyaluronic Acid for Cartilage Tissue Engineering Applications

Abstract

Diseases in articular cartilages have affected millions of people globally. Although the biochemical and cellular composition of articular cartilages is relatively simple, there is a limitation in the self-repair ability of the cartilage. Therefore, developing strategies for cartilage repair is very important. Here, we report on a new liquid resin preparation process of water-based polyurethane based photosensitive materials with hyaluronic acid with application of the materials for 3D printed customized cartilage scaffolds. The scaffold has high cytocompatibility and is one that closely mimics the mechanical properties of articular cartilages. It is suitable for culturing human Wharton’s jelly mesenchymal stem cells (hWJMSCs) and the cells in this case showed an excellent chondrogenic differentiation capacity. We consider that the 3D printing hybrid scaffolds may have potential in customized tissue engineering and also facilitate the development of cartilage tissue engineering.

PAM/GO/gel/SA composite hydrogel conduit with bioactivity for repairing peripheral nerve injury

“…In recent decades, the development of biomaterials and the preparation of artificial implants were reported to be well applied to repair various damaged tissues . Until now, various biological materials made of natural materials or synthetic materials have been used for peripheral nerve regeneration, including hyaluronic acid, silk fibroin, and polypropylene alcohol, sodium alginate, gelatin, chitosan, polyacrylamide, etc. These biomaterials have great application prospects in repairing peripheral nerve injury, but the effect still cannot meet the requirements of rapid regeneration and functional recovery of peripheral nerve injury in clinic.…”

Construction of polyacrylamide/graphene oxide/gelatin/sodium alginate composite hydrogel with bioactivity for promoting Schwann cells growth

“…It has been widely recognized that the development of biomaterials and the preparation of artificial implants could be well applied for repairing various injured tissues in the last several decades . As of now, a variety of biomaterials made from natural materials or synthetic materials have been used for peripheral nerve regeneration, including chitosan, silk fibroin, sodium alginate (SA), gelatin (Gel), polypropylene alcohol, polyacrylamide (PAM), hyaluronic acid, and so forth. The above‐mentioned biomaterials have a considerable prospect for repairing PNI, but the effect is still not as good as that of autologous graft, therefore, it is necessary to further develop suitable artificial implants for promoting nerve regeneration.…”

Special Issue: 3D Printing for Biomedical Engineering

“…Tsai et al reported another composite by adding magnesium-calcium silicate to polycaprolactone powder, and bone scaffolds were successfully fabricated via a laser sintering method [20]. Shie et al developed a new photocurable liquid resin which incorporates both polyurethane and hyaluronic acid, and when cultured with mesenchymal stem cells, the 3D-printed hybrid scaffold was able to promote chondrogenic differentiation [21]. Wang et al reported the printing and clinical use of patient-specific surgical aids in two studies: spinal surgery and complex pelvic fracture [22,23].…”