3D printing of drugs: expanding the options for child-tailored pharmacotherapy

Kampen, Eveline E.M. van; Willemsteijn, Luc; Ruijgrok, Elisabeth J.

doi:10.1136/archdischild-2021-321629

Cited by 6 publications

(7 citation statements)

References 7 publications

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“…Three-dimensional printing technology is highly flexible and can be used to print targeted medicines by adjusting model parameters such as size, shape, or fill rate [ 16 ]. For pediatric patients, 3D printing technology can be used to produce low-dose personalized medicines suitable for children, and can also be used to improve the appearance and taste of the medicines to increase the compliance of pediatric patients [ 17 , 18 , 19 ]; for elderly patients who have difficulty swallowing, 3D printing technology can prepare loose and porous preparations, thus, helping them to take medication; for patients who take multiple drugs at the same time, different drugs can be partitioned and combined into a single tablet to avoid errors or missed drugs, which can increase the safety and effectiveness of medication; in addition, specially shaped preparations can be printed or special symbols can be printed on the surface of the preparation to provide convenience for patients with visual impairment [ 20 , 21 , 22 ]. The advantages of 3D printing technology for personalized drug delivery provide technical support for people to achieve personalized medicine, and some 3D printed drug companies are moving towards the goal of personalized medicine, such as FabRx in the UK, which prepares personalized drugs for children with maple diabetes, and has placed SSE printers in the pharmacy of a Spanish hospital and conducted clinical trials on the subject [ 23 ].…”

Section: The Advantages Of 3d Printing Technology In Pharmaceuticalsmentioning

confidence: 99%

A Review of 3D Printing Technology in Pharmaceutics: Technology and Applications, Now and Future

Wang

Chen²,

Han³

et al. 2023

Pharmaceutics

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Three-dimensional printing technology, also called additive manufacturing technology, is used to prepare personalized 3D-printed drugs through computer-aided model design. In recent years, the use of 3D printing technology in the pharmaceutical field has become increasingly sophisticated. In addition to the successful commercialization of Spritam® in 2015, there has been a succession of Triastek’s 3D-printed drug applications that have received investigational new drug (IND) approval from the Food and Drug Administration (FDA). Compared with traditional drug preparation processes, 3D printing technology has significant advantages in personalized drug manufacturing, allowing easy manufacturing of preparations with complex structures or drug release behaviors and rapid manufacturing of small batches of drugs. This review summaries the mechanisms of the most commonly used 3D printing technologies, describes their characteristics, advantages, disadvantages, and applications in the pharmaceutical industry, analyzes the progress of global commercialization of 3D printed drugs and their problems and challenges, reflects the development trends of the 3D printed drug industry, and guides researchers engaged in 3D printed drugs.

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Section: The Advantages Of 3d Printing Technology In Pharmaceuticalsmentioning

confidence: 99%

A Review of 3D Printing Technology in Pharmaceutics: Technology and Applications, Now and Future

Wang

Chen²,

Han³

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

“…First, the product needs to be accurately designed in 3D and used with auxiliary design tools for precise positioning. Second, powerful molding equipment is required, and third, the performance and molding material requirements must be met[ 16 ]. Because 3D printing has revolutionized traditional manufacturing and is a subversion of traditional manufacturing, printing materials have constrained the development of 3D printing.…”

Section: Elements Of Different Emerging Technologiesmentioning

confidence: 99%

Application experience and research progress of different emerging technologies in plastic surgery

Yang¹,

Yang²,

Huang³

et al. 2023

World J Clin Cases

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In the diagnosis and treatment of plastic surgery, there are structural processing problems, such as positioning, moving, and reconstructing complex three-dimensional structures. Doctors operate according to their own experience, and the inability to accurately locate these structures is an important problem in plastic surgery. Emerging digital technologies such as virtual reality, augmented reality, and three-dimensional printing are widely used in the medical field, particularly in plastic surgery. This article reviews the development of these three technical concepts, introduces the technical elements and specific applications required in plastic surgery, summarizes the application status of the three technologies in plastic surgery, and summarizes prospects for future development.

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“…The healthcare professionals from the abovementioned study suggested multiple API's for which there currently is a lack of oral products, a need for oral personalized doses, a need for orodispersible drug products, a need for combination products, or a need for better treatment options [68]. Candidate API's for 3D-printed medicine for the pediatric population were also suggested in a viewpoint article [69]. The authors suggest focusing the development of 3D-printed medication firstly to API's that lack a suitable oral formulation.…”

Section: Eligible Active Pharmaceutical Ingredientsmentioning

confidence: 99%

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

et al. 2022

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3D printing of pediatric-centered drug formulations can provide suitable alternatives to current treatment options, though further research is still warranted for successful clinical implementation of these innovative drug products. Extensive research has been conducted on the compliance of 3D-printed drug products to a pediatric quality target product profile. The 3D-printed tablets were of particular interest in providing superior dosing and release profile similarity compared to conventional drug manipulation and compounding methods, such as oral liquids. In the future, acceptance of 3D-printed tablets in the pediatric patient population might be better than current treatments due to improved palatability. Further research should focus on expanding clinical knowledge, providing regulatory guidance and expansion of the product range, including dosage form possibilities. Moreover, it should enable the use of diverse good manufacturing practice (GMP)-ready 3D printing techniques for the production of various drug products for the pediatric patient population.

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3D printing of drugs: expanding the options for child-tailored pharmacotherapy

Cited by 6 publications

References 7 publications

A Review of 3D Printing Technology in Pharmaceutics: Technology and Applications, Now and Future

A Review of 3D Printing Technology in Pharmaceutics: Technology and Applications, Now and Future

Application experience and research progress of different emerging technologies in plastic surgery

3D Printing of Pediatric Medication: The End of Bad Tasting Oral Liquids?—A Scoping Review

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