3D printing of metal–organic framework incorporated porous scaffolds to promote osteogenic differentiation and bone regeneration

Abstract

Bone substitute biomaterials, whose compositions and structures both play vital roles in bone defect healing, hold promising prospects in the clinical treatment of bone defects. Three-dimensional (3D) printed porous scaffolds...

Vascularized bone regeneration accelerated by 3D-printed nanosilicate-functionalized polycaprolactone scaffold

“…3D-printed biomaterials have attracted considerable attention in bone tissue regeneration due to their flexible and convenient manipulation [ 8 ]. Scaffolds with porous structures ensure the transport of oxygen and nutrients, ingrowth of vasculature and migration of mesenchymal stem cells [ 30 ]. Previous studies have indicated that scaffolds with pore sizes between 300 and 500 μm and porosities higher than 50% could not only promote cell proliferation and osteogenic differentiation but also not jeopardize the mechanical properties of scaffolds [ 31–33 ].…”

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

“…The PCL/DCPD/nanoZIF-8 porous composite scaffold constructed by Zhong et al using extrusion 3D printing technology has good bionic structure and mechanical properties. In vivo and in vitro studies have shown that the scaffold can control the release of calcium and zinc ions and promote the differentiation of bone marrow mesenchymal stem cells into osteoblasts [ 70 ]. As shown in Figure 5 , nanoZIF-8 as a metal-organic framework incorporated into a 3D printed complex scaffold has good biocompatibility, increases the proliferation activity of bone marrow mesenchymal stem cells, promotes cell adhesion and proliferation, and promotes new growth in the body, which is of great significance for the treatment of bone defects.…”

“…Significant differences were marked among a series of points for each group, respectively. Data were shown as mean ± SD, ∗∗∗ p < 0.001 ( n = 4) [ 70 ]. Used with permission from the Royal Society of Chemistry.…”

A periodontal tissue regeneration strategy via biphasic release of zeolitic imidazolate framework-8 and FK506 using a uniaxial electrospun Janus nanofiber

“…[11][12][13][14] Recent research studies have shown that ZIF-8 NPs can be applied as an effective modification material for antibacterial treatment as well as bone regeneration. [15][16][17][18] Therefore, we suspect that ZIF-8 NPs may be a great candidate for the modification of GTR membranes. However, under the longterm stimulation of periodontitis, bone formation is inhibited, thus a drug with osteogenesis and anti-inflammatory functions is required for periodontal tissue regeneration.…”