3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction

Gui, Xingyu; Peng, Zhiyu; Song, Ping; Chen, Li; Xu, Xiahong; Li, Hairui; Tang, Pei; Wang, Yixi; Su, Zixuan; Kong, Qingquan; Zhang, Zhenyu; Li, Zhengyong; Cen, Ying; Zhou, Changchun; Fan, Yujiang; Zhang, Xingdong

doi:10.1007/s42242-023-00242-6

Cited by 28 publications

(5 citation statements)

References 45 publications

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“…The 3D printing and sintering were followed as in our previous research. − In brief, 10 g of hydroxyapatite powder (purchased from Engineering Research Center for Biomaterials at Sichuan University) and 10 mL of polyvinyl butyral solution (10% in water, w/w) were mixed in a centrifugal mixer (ARE-310, THINKY, Japan). Then, the mixture was transferred to the printer cartridge for further printing.…”

Section: Materials and Methodsmentioning

confidence: 99%

3D Printed Calcium Phosphate Physiochemically Dual-Regulating Pro-Osteogenesis and Antiosteolysis for Enhancing Bone Tissue Regeneration

Wu,

Pei,

Dou

et al. 2024

ACS Appl. Mater. Interfaces

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Osteoblasts and osteoclasts are two of the most important types of cells in bone repair, and their bone-forming and bone-resorbing activities influence the process of bone repair. In this study, we proposed a physicochemical bidirectional regulation strategy via ration by physically utilizing hydroxyapatite nanopatterning to recruit and induce MSCs osteogenic differentiation and by chemically inhibiting osteolysis activity through the loaded zoledronate. The nanorod-like hydroxyapatite coating was fabricated via a modified hydrothermal process while the zoledronic acid was loaded through the chelation within the calcium ions. The fabrication of a hydroxyapatite/zoledronic acid composite biomaterial. This biomaterial promotes bone tissue regeneration by physically utilizing hydroxyapatite nanopatterning to recruit and induce MSCs osteogenic differentiation and by chemically inhibiting osteolysis activity through the loaded zoledronate. The nanorod-like hydroxyapatite coating was fabricated via a modified hydrothermal process while the zoledronic acid was loaded through the chelation within the calcium ions. The in vitro results tested on MSCs and RAW 246.7 indicated that the hydroxyapatite enhanced cells' physical sensing system, therefore enhancing the osteogenesis. At the same time the zoledronic acid inhibited osteolysis by downregulating the RANK-related genes. This research provides a promising strategy for enhancing bone regeneration and contributes to the field of orthopedic implants.

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Section: Materials and Methodsmentioning

confidence: 99%

3D Printed Calcium Phosphate Physiochemically Dual-Regulating Pro-Osteogenesis and Antiosteolysis for Enhancing Bone Tissue Regeneration

Wu,

Pei,

Dou

et al. 2024

ACS Appl. Mater. Interfaces

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“…55 The microstructure of the scaffold in the NP/SA (1 : 1) group showed a more regular network structure with closer connections, which was beneficial for the transport, metabolism and transportation of nutrients, oxygen and wastes within the scaffolds. 25,56 Additionally, as the NP content of the scaffolds increased, the pore sizes decreased. 49 This phenomenon can be attributed to the fact that higher proportions of NP occupy the composite hydrogel space, leading to a reduction in pore size.…”

Section: Papermentioning

confidence: 99%

3D printing nacre powder/sodium alginate scaffold loaded with PRF promotes bone tissue repair and regeneration

Liu,

Hu,

Huang

et al. 2024

Biomater. Sci.

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“…Finally, 3D printing allows the incorporation of various elements such as bioceramics, polymers, antibacterial agents, stem cells, and bioactive factors into the created anatomically consistent constructs, combining their advantages for better osteogenesis and angiogenesis, and the treatment of infection and cancer to positively affect bone regeneration ( Shukla and Maiti, 2022 ; Gui et al, 2023 ; Tripathi et al, 2023 ).…”

Section: 3d Printed Peek For Bone Reconstructionmentioning

confidence: 99%

Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects

Su,

Qiao,

Xiao

et al. 2023

Front. Bioeng. Biotechnol.

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The clinical challenge of bone defects in the craniomaxillofacial region, which can lead to significant physiological dysfunction and psychological distress, persists due to the complex and unique anatomy of craniomaxillofacial bones. These critical-sized defects require the use of bone grafts or substitutes for effective reconstruction. However, current biomaterials and methods have specific limitations in meeting the clinical demands for structural reinforcement, mechanical support, exceptional biological performance, and aesthetically pleasing reconstruction of the facial structure. These drawbacks have led to a growing need for novel materials and technologies. The growing development of 3D printing can offer significant advantages to address these issues, as demonstrated by the fabrication of patient-specific bioactive constructs with controlled structural design for complex bone defects in medical applications using this technology. Poly (ether ether ketone) (PEEK), among a number of materials used, is gaining recognition as a feasible substitute for a customized structure that closely resembles natural bone. It has proven to be an excellent, conformable, and 3D-printable material with the potential to replace traditional autografts and titanium implants. However, its biological inertness poses certain limitations. Therefore, this review summarizes the distinctive features of craniomaxillofacial bones and current methods for bone reconstruction, and then focuses on the increasingly applied 3D printed PEEK constructs in this field and an update on the advanced modifications for improved mechanical properties, biological performance, and antibacterial capacity. Exploring the potential of 3D printed PEEK is expected to lead to more cost-effective, biocompatible, and personalized treatment of craniomaxillofacial bone defects in clinical applications.

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3D printing of personalized polylactic acid scaffold laden with GelMA/autologous auricle cartilage to promote ear reconstruction

Cited by 28 publications

References 45 publications

3D Printed Calcium Phosphate Physiochemically Dual-Regulating Pro-Osteogenesis and Antiosteolysis for Enhancing Bone Tissue Regeneration

3D Printed Calcium Phosphate Physiochemically Dual-Regulating Pro-Osteogenesis and Antiosteolysis for Enhancing Bone Tissue Regeneration

3D printing nacre powder/sodium alginate scaffold loaded with PRF promotes bone tissue repair and regeneration

Research progress of 3D printed poly (ether ether ketone) in the reconstruction of craniomaxillofacial bone defects

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