3D Printing Technologies: Recent Development and Emerging Applications in Various Drug Delivery Systems

Jacob, Shery; Nair, Anroop B.; Patel, Vaibhavi; Shah, Jigar

doi:10.1208/s12249-020-01771-4

Cited by 75 publications

(36 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Another technique, stereolithography, is a laser-based 3D printing technology that makes use of UV-sensitive liquid resins for fabricating the 3D objects [113]. PNIPAAm has been employed for creating thermo-responsive hydrogels that can be used in drug delivery applications [114].…”

Section: D Printingmentioning

confidence: 99%

“…On the other hand, inkjet printing has been used to create highly porous structures. Material's particle size must be greater than 1 µm, its viscosity has to be lower than 20 cP, and possess a surface tension around 50 mN/m [113].…”

Section: D Printingmentioning

confidence: 99%

“…The scaffold showed cytocompatibility to L929 cells, and its stability was related to the content of gelatin [115]. Another technique, stereolithography, is a laser-based 3D printing technol makes use of UV-sensitive liquid resins for fabricating the 3D objects [113]. PN has been employed for creating thermo-responsive hydrogels that can be used delivery applications [114].…”

Section: D Printingmentioning

confidence: 99%

See 2 more Smart Citations

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

View full text Add to dashboard Cite

Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

show abstract

Section: D Printingmentioning

confidence: 99%

Section: D Printingmentioning

confidence: 99%

Section: D Printingmentioning

confidence: 99%

See 1 more Smart Citation

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…On the other hand, the buccal film formulations can be easily scaled up because of the adaptable and feasible nature of film manufacturing processes such as solvent casting and hot melt extrusion techniques. Advancement in 3D printing technology will also help in accommodating adequate doses of drugs in buccal films with limited dimensions [ 17 ]. Moreover, the buccal films are prepared using generally regarded as safe excipients and, hence, could be a suitable drug delivery system for the pediatric population [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation

et al. 2021

Self Cite

View full text Add to dashboard Cite

The reduced therapeutic efficacy of rizatriptan in migraine treatment is primarily due to low oral bioavailability and extensive first pass metabolism. The purpose of this investigation was to optimize the thin mucoadhesive buccal film of rizatriptan and assess the practicability of its development as a potential substitute for conventional migraine treatment. Buccal films (FR1–FR10) were fabricated by a conventional solvent casting method utilizing a combination of polymers (Proloc, hydroxypropyl methylcellulose and Eudragit RS 100). Drug-loaded buccal films (F1–F4) were examined for mechanical, mucoadhesive, swelling and release characteristics. In vivo pharmacokinetics parameters of selected buccal film (F1) in rabbits were compared to oral administration. Films F1–F4 displayed optimal physicomechanical properties including mucoadhesive strength, which can prolong the buccal residence time. A biphasic, complete and higher drug release was seen in films F1 and F4, which followed Weibull model kinetics. The optimized film, F1, exhibited significantly higher (p < 0.005) rizatriptan buccal flux (71.94 ± 8.26 µg/cm2/h) with a short lag time. Film features suggested the drug particles were in an amorphous form, compatible with the polymers used and had an appropriate surface morphology suitable for buccal application. Pharmacokinetic data indicated a significantly higher rizatriptan plasma level (p < 0.005) and Cmax (p < 0.0001) upon buccal film application as compared to oral solution. The observed AUC0–12h (994.86 ± 95.79 ng.h/mL) in buccal treatment was two-fold higher (p < 0.0001) than the control, and the relative bioavailability judged was 245%. This investigation demonstrates the prospective of buccal films as a viable and alternative approach for effective rizatriptan delivery.

show abstract

“…AM techniques are modular approaches based on the assembly/sintering of layered structures obtained by continuous or discontinuous processes ( Salerno et al, 2019 ). The advantages of employing AM processes, such as 3D printing, include the capability of precisely controlling the spatial loading of an active molecule within even minute quantities and generate multiple delivery profiles by creating different depots and complex geometries ( Caballero-Aguilar et al, 2020 ; Jacob et al, 2020 ). These aspects enabled the compounding of personalized dosage form to minimize costs, to improve patient compliance, and to maximize drug efficacy.…”

Section: Introduction To Computer-aided Design and Manufacturing Of Drug Delivery Scaffoldsmentioning

confidence: 99%

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Salerno¹,

Netti

2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

In the last decade, additive manufacturing (AM) processes have updated the fields of biomaterials science and drug delivery as they promise to realize bioengineered multifunctional devices and implantable tissue engineering (TE) scaffolds virtually designed by using computer-aided design (CAD) models. However, the current technological gap between virtual scaffold design and practical AM processes makes it still challenging to realize scaffolds capable of encoding all structural and cell regulatory functions of the native extracellular matrix (ECM) of health and diseased tissues. Indeed, engineering porous scaffolds capable of sequestering and presenting even a complex array of biochemical and biophysical signals in a time- and space-regulated manner, require advanced automated platforms suitable of processing simultaneously biomaterials, cells, and biomolecules at nanometric-size scale. The aim of this work was to review the recent scientific literature about AM fabrication of drug delivery scaffolds for TE. This review focused on bioactive molecule loading into three-dimensional (3D) porous scaffolds, and their release effects on cell fate and tissue growth. We reviewed CAD-based strategies, such as bioprinting, to achieve passive and stimuli-responsive drug delivery scaffolds for TE and cancer precision medicine. Finally, we describe the authors’ perspective regarding the next generation of CAD techniques and the advantages of AM, microfluidic, and soft lithography integration for enhancing 3D porous scaffold bioactivation toward functional bioengineered tissues and organs.

show abstract

3D Printing Technologies: Recent Development and Emerging Applications in Various Drug Delivery Systems

Cited by 75 publications

References 124 publications

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Development of Mucoadhesive Buccal Film for Rizatriptan: In Vitro and In Vivo Evaluation

Review on Computer-Aided Design and Manufacturing of Drug Delivery Scaffolds for Cell Guidance and Tissue Regeneration

Contact Info

Product

Resources

About