3D‐speckle tracking echocardiography for assessment of coronary artery disease severity in stable angina pectoris

Abstract

Background and Aim: Stable angina pectoris is a common disease that may cause disability. Some noninvasive new methods can be useful for the detection of earlystage coronary artery disease. The relationship between coronary artery disease (CAD) severity and resting 3-dimensional-speckle tracking echocardiography (3D-STE) in stable angina pectoris patients was evaluated in this study. Methods:One hundred and twenty consecutive patients between 18-80 years of age and without a history of CAD to whom elective coronary angiography was planned after positive stress test or myocardial perfusion scintigraphy were enrolled in the study. 3D-STE was performed and global longitudinal strain (GLS), global circumferential strain (GCS), global radial strain (GRS), and global area strain (GAS) were measured before coronary angiography. A Gensini score of ≥20 was accepted as critical CAD. Correlation between Gensini scores and 3D-STE results were evaluated.Results: Mean age was 60.7 ± 10.01 years, and 55% of the patient population were male. There were not any significant differences between critical CAD and noncritical CAD groups for age, gender, history of hypertension, diabetes mellitus, hyperlipidemia, and Left Ventricular Ejection Fraction. Mean GLS was −12, GCS was −18.8, GRS was 33.4, GAS was −28.9, and mean Gensini score was 18.8. GLS and all other strain parameters were significantly worse in patients with critical CAD group compared with noncritical CAD group and also positive linear correlation was observed between Gensini score and all measured strain parameters (r = 0.568, P < 0.001 for Gensini score and GLS; r = 0.617, P < 0.001 for Gensini score and GAS). A GLS value of >−10 has 88.9% sensitivity and 92.9% specificity; A GAS value of >−21 has 97.2% sensitivity and 88.1% specificity to detect critical CAD.Conclusions: 3D-STE is a noninvasive and handy parameter to detect subclinical left ventricular dysfunction and global strain values were significantly correlated with CAD severity. GAS has the sensitivity of 97.2% and specificity of 88.1% to detect critical CAD. Adding 3D strain echocardiography to exercise test or myocardial perfusion scintigraphy might increase sensitivity to detect critical CAD in clinical practice. K E Y W O R D S3D -speckle tracking echocardiography, Gensini score, stable angina pectoris | 321 DOGDUS et al.

Block Matching Pyramid Algorithm-Based Analysis on Efficacy of Shexiang Baoxin Pills Guided by Echocardiogram (ECG) on Patients with Angina Pectoris in Coronary Heart Disease

“…Besides, the heart beat was too strong, indicating that the heart function was abnormal. It was in line with the actual situation of CHD angina patients [19].…”

Utility of global longitudinal strain to detect significant coronary artery disease, its extent and severity in patients with stable ischemic heart disease

“…Myocardial fibrosis could have led to reduced GLS in some of the subjects but cardiac magnetic resonance imaging (MRI) was not performed. 3D‐speckle tracking echocardiography was shown to be highly sensitive in detection of critical CAD by Dogdus et al 20 Layer‐specific strain imaging was done during Dypridamole stress echocardiography by Mandoli et al They concluded that global circumferential strain was valuable for microvascular disease, and endocardial GLS was the best indicator for wall deformation in macrovascular disease 21 . Thus, performing 3D‐speckle tracking echocardiography or finding layer‐specific strain during Dipyridamole stress could have refined or enhanced our findings.…”

Pseudoexfoliation syndrome: Are the eyes the mirror of the heart?

“…The results of this study suggested that a more detailed cardiovascular evaluation of PEX patients might be needed. From this point of view, the subclinical myocardial dysfunction in strain echocardiography imaging correlated with the severity of coronary artery disease should be kept in mind 28 …”

“…From this point of view, the subclinical myocardial dysfunction in strain echocardiography imaging correlated with the severity of coronary artery disease should be kept in mind. 28 The cardiac effects of PEX syndrome have been analyzed in several studies by traditional echocardiographic methods. In an echocardiography study of Bojic et al which is conducted with 51 participants, consisting of 27 PEX patients and 24 control groups, they found that there is subclinical diastolic dysfunction in PEX patients and suggested that transmitral filling may be impaired in PEX patients.…”