(+)-[3H]SK&amp;F 10,047 sites in rat liver

Samovilova, N. N.; Nagornaya, L. V.; Vinogradov, V. A.

doi:10.1016/0014-2999(88)90784-4

Cited by 53 publications

(12 citation statements)

References 6 publications

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“…o receptor is present in several peripheral tissues such as rat liver (Samovilova et al, 1988;McCann and Su, 1991), guinea-pig ileum (Roman et al, 1988(Roman et al, ,1989Campbell et al, 1989) and guinea-pig vas deferens (Su and Wu, 1990). Functions of the o receptor in those tissues have just begun to be revealed.…”

Section: Physiological Effectsmentioning

confidence: 99%

“…These include pituitary (Wolfe et al, 1989), adrenal gland (Rogers et al, 1989;Wolfe et al 1989), testis, ovary (Wolfe et al, 1989), spleen , peripheral blood leukocytes (Wolfe et al, 1989), vas deferens (Su and Wu, 1990), and pineal gland (Jansen et al, 1990). The r~ receptor also exists in peripheral tissues such as gastrointestinal tract (Roman et al, 1988) and liver (Samovilova et al, 1988). The discovery that progesterone and certain steroids interact with a receptors in the brain and immune tissues has raised a possibility that 0 receptors may represent links between nervous, endocrine and immune systems .…”

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confidence: 99%

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σ receptors

1991

European Journal of Biochemistry

145

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The σ receptor is a neuronal substrate that binds several psychoactive compounds. These include cocaine, some steroids, dextromethorphan, phencyclidine (PCP), and benzomorphans such as pentazocine and N‐allyl‐normatezocine (SKF‐10047). Many newer atypical antipsychotic drugs also bind to the σ receptor. The σ receptor, however, is not the PCP receptor. The σ receptor exists in the central nervous system, endocrine, immune and certain peripheral tissues. Progesterone and certain steroids have been shown to represent endogenous ligands for the σ receptor. The σ receptor resides likely in the nonsynaptic region of the plasma membrane. The σ receptor exists in two forms: high‐affinity and low‐affinity. The solubilized σ receptor retains all of the pharmacological characteristics of a membrane‐bound receptor. A major physiological role of the σ receptor may involve the modulation of a tonic potassium channel.

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Section: Physiological Effectsmentioning

confidence: 99%

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confidence: 99%

σ receptors

1991

European Journal of Biochemistry

145

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“…They were subsequently found to be distributed in a variety of distinct regions of the central nervous system [3], as well as in endocrine-related structures (41, gastrointestinal tract [5], liver [6] and kidney [7]. These receptors were further identified on human peripheral blood mononuclear cells [8] and confirmed on mouse lymphocytes and rat splenocytes [9,101.…”

Section: Introductionmentioning

confidence: 97%

Enhancement of endotoxin‐induced interleukin‐10 production by SR 31747A, a sigma ligand

et al. 1995

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SR 31747A is a new sigma ligand eliciting immunosuppressive and anti-inflammatory properties. Here, we show that SR 31747A greatly enhances lipopolysaccharide (LPS)-induced systemic release of interleukin (IL)-10, while it inhibits the secretion of tumor necrosis factor (TNF)-alpha and interferon (IFN)-gamma. In line with this finding, we also show by using quantitative reverse transcription-polymerase chain reaction analysis that SR 31747A increased LPS-induced IL-10 mRNA accumulation in spleen cells, whereas the level of both TNF-alpha and IFN-gamma mRNA was dramatically decreased. The enhancement of IL-10 production by SR 31747A treatment was also apparent in nude and severe-combined immunodeficient mice treated with LPS, clearly indicating that T and B cells were not involved. Finally, SR 31747A conferred protection against the lethal effect of LPS. The finding that SR 31747A strongly stimulates the synthesis of the natural anti-inflammatory cytokine IL-10, a property not observed with dexamethasone, provides new insights for the clinical use of this original compound, particularly in chronic inflammatory diseases where IL-10 is believed to be a pivotal regulatory component.

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“…They were subsequently found to be distributed in a variety of distinct regions of the central nervous system (4), as well as in endocrine-related structures (5), gastrointestinal tract (6), liver (7), and kidney (8). Sigma receptors were further identified in human peripheral blood mononuclear cells (9 -12), and their presence was confirmed in rat spleen.…”

mentioning

confidence: 99%