Multi-user multiple-input and multiple-output (MU-MIMO) systems are the mainstream of current antenna design. This paper proposes a dual-band 6 × 6 MIMO glasses antenna for Wi-Fi 6E and Wi-Fi 7 indoor wireless communication. The six antennas have the same structure, all of which are F-shaped monopole antennas. They are on the left and right temples, at the upper and lower ends of the left and right frames, which effectively uses the space of the glasses. The substrate uses FR4 (εr=4.4, tanδ=0.02). The antenna design is compact (9 mm × 50 mm × 0.8 mm) and the glasses model is made of FR4. The overall model is similar to virtual reality (VR) glasses, which are convenient for a user to wear. The proposed antenna has three working frequency bands, at 2.4 GHz, 5 GHz, and 6 GHz. Through matching and optimization, the reflection coefficient can be lower than −10 dB. In addition, this paper evaluates two usage environments for simulation and measurement on the head and free space. The measurement results show that when the operating frequency band is at 2.45 GHz, the antenna efficiency is 86.1%, and the antenna gain is 1.9 dB. At 5.5 GHz, the antenna efficiency is 86.5%, and the antenna gain is 4.4 dB. At 6.7 GHz, the antenna efficiency is 85.4%, and the antenna gain is 3.7 dB. When the isolation of the MIMO antenna system is optimized, the low-frequency band is better than −10 dB, and the high-frequency band is better than −20 dB. The measured envelope correlation coefficient (ECC) values are all lower than 0.1.