4-Cyclopropyl-1-(1-methyl-4-nitro-1H-imidazol-5-yl)-1H-1,2,3-triazole and Ethyl 1-(1-methyl-4-nitro-1H-imidazol-5-yl)-1H-1,2,3-triazole-4-carboxylate

New 2‐nitroimidazole‐N‐acylhydrazones, analogs of benznidazole, as anti‐Trypanosoma cruzi agents

“…[13] To decorrelate the effects of the desired activity and toxicity of nitroimidazoles, several researchers have been developing scientific works in this line. [14][15][16][17] Following the clarification of its lower toxicity extent to the host, the use of medicinal chemistry tools to propose new bioactive molecules in the research and development process has been shown to be strategic, allowing several approaches, such as bioisosterism, molecular simplification, and molecular hybridization. [18] Therefore, to demystify the participation of only the nitro group with toxicological activity in nitroimidazoles, we carried out a study in which nitroimidazoles with different N-1 chains were synthesized, with different positions of the nitro group and with the inclusion or absence of the methyl group in the imidazole ring.…”