4'-O-Methylstephavanine from Stephania abyssinica

Dagne, Ermias; Gunatilaka, A. A. Leslie; Kingston, David G. I.; Alemu, Mekbib

doi:10.1021/np50101a029

Cited by 16 publications

(5 citation statements)

References 4 publications

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“…Stephania abyssinica water extract showed good activity (IC 50 = 22.90 µg/mL) against K 39. Previous phytochemical investigations on S. abyssinica revealed the presence of hasubanan alkaloids (Kupchan et al, 1973;Southon and Buckingham, 1989;Dagne et al, 1993) in the ethanol extract of the roots.…”

Section: Resultsmentioning

confidence: 96%

Anti‐plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine

Muregi¹,

Chhabra

Njagi³

et al. 2004

Phytotherapy Research

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Sixty organic and aqueous extracts of eleven plants used for the control of malaria by local communities in Kisii District, Kenya were screened for in vitro anti-plasmodial activity. The plants selection was based on existing ethnobotanical information and interviews with local communities. The extracts were tested against chloroquine sensitive and resistant laboratory adapted strains of Plasmodium falciparum. The study revealed that 63.6% of the plants were active (IC 50 ≤ ≤ ≤ ≤ ≤ 100 µ µ µ µ µg/mL). Extracts of four plants, Ekebergia capensis, Stephania abyssinica, Ajuga remota and Clerodendrum myricoides gave IC 50 values below 30 µ µ µ µ µg/mL against both chloroquine sensitive and resistant P. falciparum strains. Combination of extracts of E. capensis and C. myricoides with chloroquine against the multi-drug resistant P. falciparum isolate (V1/S) revealed synergistic effect. The plants which showed activity may be useful as sources for novel anti-plasmodial compounds.

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Section: Resultsmentioning

confidence: 96%

Anti‐plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine

Muregi¹,

Chhabra

Njagi³

et al. 2004

Phytotherapy Research

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“…However, the chloroform, ethyl acetate, methanol and water extracts gave good IC 50 values (<5 μg ml −1 ) suggesting that the plant extracts have a high in vitro anti-plasmodial activity. The methanolic extract of C. myricoides leaves showed good anti-plasmodial activity (19). Similar findings were observed in the present study, with high anti-plasmodial activity in ethanol, butanol, chloroform and ethyl acetate extract.…”

Section: Discussionmentioning

confidence: 99%

In Vitro Anti‐Plasmodial Activity of Trigonella foenum–graecum L.

Palaniswamy

Pradeep

Sathya

et al. 2008

Evidence-Based Complementary and Alternative Medicine

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Developing countries, where malaria is one of the most prevalent diseases, still rely on traditional medicine as a source for the treatment of this disease. For the present study, Trigonella foenum-graecum L. (fenugreek) were collected from Coimbatore, Tamilnadu, India. The test plant has been used in India by traditional healers for the treatment of fever as well as other diseases. The active principle was extracted out in different solvent systems to assess the anti-plasmodial potential, with an aim that they can further be utilized to formulate drugs. In vitro anti-plasmodial assay of the extracted fractions of fenugreek leaves was carried out using laboratory adapted chloroquine sensitive and resistant Plasmodium falciparum isolates. Schizont maturation inhibition assay was adopted to analyze the potential of the extracts. Ethanol extract (50%) seemed to possess profound anti-plasmodial activity with IC50 value of 8.75 ± 0.35 µg ml−1 and 10.25 ± 0.35 µg ml−1 against chloroquine sensitive and resistant P. falciparum isolates, respectively. Among the investigated six fractions of the plant extracts, two were found to have significant anti-plasmodial activity with IC50 values <10 µg ml−1, namely ethanol and butanol extracts. Two extracts chloroform and ethyl acetate showed moderate activity with IC50 values ranging from 10 to 20 µg ml−1, and the other two extracts, hexane and water appeared to be inactive with IC50 values >85 µg ml−1. In addition, preliminary phytochemical screening of the various extracts indicated the presence of alkaloids, saponin, tannin like phenolic compounds, flavonoids and steroids.

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“…The reported phytochemicals from Stephania abyssinica Walp. include 4-O-methylstephavanine (1) and stephavanine (2) ( Figure 9) (Dagne et al, 1993).…”

Section: Medicinal Properties and Antimalarial Activitiesmentioning

confidence: 99%

A review of ethnopharmacology of the commonly used antimalarial herbal agents for traditional medicine practice in Ethiopia

Amuamuta¹,

Kesara²

2015

Afr. J. Pharm. Pharmacol.

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Malaria is one of the parasitic infections that cause enormous public health, economic, and emotional burden in many tropical and subtropical countries of the world. Resistance of the vector mosquitoes to the current insecticides as well as the emergence of multidrug resistance by malaria parasite to widely used antimalarial drugs has made malaria control and treatment much more difficult. New alternative antimalarial drugs and approaches for mosquito control are urgently required. Ethiopia, as most of the African continent countries, is rich in a wide range of tropical habitats, remarkable biodiversity, and the uses of traditional medicines for treatment of various illnesses. The article thus focuses on review of ethnopharmacological activities (medicinal properties), phytochemistry, and safety (toxicity) of some of the commonly used antimalarial herbal agents in Ethiopia and around which could have significant potential for antimalarial drug discovery and development.

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4'-O-Methylstephavanine from Stephania abyssinica

Cited by 16 publications

References 4 publications

Anti‐plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine

Anti‐plasmodial activity of some Kenyan medicinal plant extracts singly and in combination with chloroquine

In Vitro Anti‐Plasmodial Activity of Trigonella foenum–graecum L.

A review of ethnopharmacology of the commonly used antimalarial herbal agents for traditional medicine practice in Ethiopia

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