4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells

Varinthra, Peeraporn; Huang, Shangyu; Wen, Zhi‐Hong; Liu, Ingrid Y.

doi:10.3390/md19010001

Cited by 7 publications

(8 citation statements)

References 39 publications

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“…Though the secondary metabolites of the fungus S . gracilariae were not, apparently, bioprospected before, those produced by unidentified Stemphylium species were also demonstrated by Zhou et al [ 96 ] and Hwang et al [ 97 ] to display antibacterial and anti-inflammatory activities.…”

Section: Discussionmentioning

confidence: 90%

“…The extract of S. gracilariae revealed weak antioxidative and photoprotective abilities, showed a high anti-inflammatory ability, and exerted a slight and strong inhibitory effect against tyrosinase, S. epidermidis and M. furfur, and collagenase and C. acnes, respectively. Though the secondary metabolites of the fungus S. gracilariae were not, apparently, bioprospected before, those produced by unidentified Stemphylium species were also demonstrated by Zhou et al [96] and Hwang et al [97] to display antibacterial and antiinflammatory activities.…”

Section: Plos Onementioning

confidence: 98%

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Marine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvageau as producers of bioactive secondary metabolites with potential dermocosmetic application

et al. 2021

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Marine fungi and, particularly, endophytic species have been recognised as one of the most prolific sources of structurally new and diverse bioactive secondary metabolites with multiple biotechnological applications. Despite the increasing number of bioprospecting studies, very few have already evaluated the cosmeceutical potential of marine fungal compounds. Thus, this study focused on a frequent seaweed in the Portuguese coast, Halopteris scoparia, to identify the endophytic marine fungi associated with this host, and assess their ability to biosynthesise secondary metabolites with antioxidative, enzymatic inhibitory (hyaluronidase, collagenase, elastase and tyrosinase), anti-inflammatory, photoprotective, and antimicrobial (Cutibacterium acnes, Staphylococcus epidermidis and Malassezia furfur) activities. The results revealed eight fungal taxa included in the Ascomycota, and in the most representative taxonomic classes in marine ecosystems (Eurotiomycetes, Sordariomycetes and Dothideomycetes). These fungi were reported for the first time in Portugal and in association with H. scoparia, as far as it is known. The screening analyses showed that most of these endophytic fungi were producers of compounds with relevant biological activities, though those biosynthesised by Penicillium sect. Exilicaulis and Aspergillus chevalieri proved to be the most promising ones for being further exploited by dermocosmetic industry. The chemical analysis of the crude extract from an isolate of A. chevalieri revealed the presence of two bioactive compounds, echinulin and neoechinulin A, which might explain the high antioxidant and UV photoprotective capacities exhibited by the extract. These noteworthy results emphasised the importance of screening the secondary metabolites produced by these marine endophytic fungal strains for other potential bioactivities, and the relevance of investing more efforts in understanding the ecology of halo/osmotolerant fungi.

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Section: Discussionmentioning

confidence: 90%

Section: Plos Onementioning

confidence: 98%

Marine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvageau as producers of bioactive secondary metabolites with potential dermocosmetic application

et al. 2021

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“…Our recent study shows that Aβ 1−42 oligomers-induced elevation of inflammatory markers in retinal pigment epithelial cells can be attenuated with a single-dose application of 4-PSB-2. Administration of this compound significantly suppressed expressions of TNF-α, COX-2, and iNOS (Varinthra et al, 2020). Besides, 4-PSB-2 is lipophilic; therefore, it is suitable as a drug candidate.…”

Section: Introductionmentioning

confidence: 90%

The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice

Varinthra

Ganesan

Huang

et al. 2021

Front. Aging Neurosci.

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Alzheimer's disease (AD) is a neurodegenerative disease characterized by an excessive inflammatory response and impaired memory retrieval, including spatial memory, recognition memory, and emotional memory. Acquisition and retrieval of fear memory help one avoid dangers and natural threats. Thus, it is crucial for survival. AD patients with impaired retrieval of fear memory are vulnerable to dangerous conditions. Excessive expression of inflammatory markers is known to impede synaptic transmission and reduce the efficiency of memory retrieval. In wild-type mice, reducing inflammation response can improve fear memory retrieval; however, this effect of this approach is not yet investigated in 3xTg-AD model mice. To date, no satisfactory drug or treatment can attenuate the symptoms of AD despite numerous efforts. In the past few years, the direction of therapeutic drug development for AD has been shifted to natural compounds with anti-inflammatory effect. In the present study, we demonstrate that the compound 4-(phenylsulfanyl) butan-2-one (4-PSB-2) is effective in enhancing fear memory retrieval of wild-type and 3xTg-AD mice by reducing the expression of TNF-α, COX-2, and iNOS. We also found that 4-PSB-2 helps increase dendritic spine density, postsynaptic density protein-95 (PSD-95) expression, and long-term potentiation (LTP) in the hippocampus of 3xTg-AD mice. Our study indicates that 4-PSB-2 may be developed as a promising therapeutic compound for treating fear memory impairment of AD patients.

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“…The 4-(phenylsulfanyl)butan-2-one (4-PSB-2) is a synthetic precursor of soft coral Cladiella australis -derived compound austrasulfone. This compound showed anti-inflammatory activity by decreasing the tumor necrosis factor alpha, cyclooxygenase-2 and inducible nitric oxide synthase expression, via the nuclear factor-kappaB (NF-κB) signaling on in vitro model of AMD (ARPE-19 cells treated with Aβ 1−42 oligomer) (Varinthra et al, 2020 ). Chien et al ( 2016 ) also tested 4-PSB-2 in a rat model subjected to optic nerve crush, revealing an anti-inflammatory and anti-apoptosis effect of this marine compound, able to preserve the visual function in vivo .…”

Section: Marine Compounds Bioactivities On Retina Diseasesmentioning

confidence: 99%

From the Sea for the Sight: Marine Derived Products for Human Vision

Brillante

Galasso

Lauritano

et al. 2022

Front. Aging Neurosci.

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Visual impairment, at different degrees, produce a reduction of patient wellness which negatively impact in many aspects of working and social activities. Eye diseases can have common cellular damages or dysfunctions (e.g., inflammation, oxidative stress, neuronal degeneration), and can target several eye compartments, primarily cornea and retina. Marine organisms exhibit high chemical diversity due to the wide range of marine ecosystems where they live; thus, molecules of marine origin are gaining increasing attention for the development of new mutation-independent therapeutic strategies, to reduce the progression of retina pathologies having a multifactorial nature and characterized by high genetic heterogeneity. This review aims to describe marine natural products reported in the recent literature that showed promising therapeutic potential for the development of new drugs to be used to contrast the progression of eye pathologies. These natural compounds exhibited beneficial and protective properties on different in vitro cell systems and on in vivo models, through different mechanisms of action, including anti-inflammatory, antioxidant, antiangiogenic/vasoprotective or cytoprotective effects. We report compounds produced by several marine source (e.g., sponges, algae, shrimps) that can be administrated as food or with target-specific strategies. In addition, we describe and discuss the uses of opsin family proteins from marine organisms for the optimization of new optogenetic therapeutic strategies.

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4-(Phenylsulfanyl) Butan-2-One Attenuates the Inflammatory Response Induced by Amyloid-β Oligomers in Retinal Pigment Epithelium Cells

Cited by 7 publications

References 39 publications

Marine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvageau as producers of bioactive secondary metabolites with potential dermocosmetic application

Marine endophytic fungi associated with Halopteris scoparia (Linnaeus) Sauvageau as producers of bioactive secondary metabolites with potential dermocosmetic application

The 4-(Phenylsulfanyl) butan-2-one Improves Impaired Fear Memory Retrieval and Reduces Excessive Inflammatory Response in Triple Transgenic Alzheimer's Disease Mice

From the Sea for the Sight: Marine Derived Products for Human Vision

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