46-jähriger Patient mit granulomatöser Prostatitis, Arthralgien und blutiger Rhinitis

Heldmann, F.; Brandt, J. Leonard; Schoppe, H.; Braun, J.

doi:10.1055/s-2006-924915

Cited by 7 publications

(2 citation statements)

References 17 publications

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“…A few GPA presented as glandular involvement, 8 such as parotid gland enlargement, prostate enlargement, salivary gland enlargement, etc. Currently, there are only a very small number of case reports of GPA with parotid gland enlargement or prostate enlargement as the main clinical symptom, 9 , 10 , 11 , 12 , 13 , 14 and the mechanism has not been completely clarified.…”

Section: Discussionmentioning

confidence: 99%

Granulomatous polyangiitis misdiagnosed as hematogenous lung abscess: A case report

Yang

Chang

2022

Clinical Case Reports

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Granuloma polyangiitis (GPA) is a necrotizing granulomatous inflammation, which is a systemic autoimmune disease that mainly affects the upper respiratory tract, lungs, and kidneys. Clinically, the clinical manifestations of GPA vary greatly, and it is extremely easy to be misdiagnosed. We report a 60‐year‐old man with granulomatous polyangiitis with dysuria and parotid gland enlargement as the first symptom. As the condition worsened, he gradually developed symptoms in multiple systems such as persistent high fever, nosebleeds, hemoptysis, skin rash, and multiple cavities in the lungs. Due to high fever, hemoptysis, and the gradual expansion of lung cavities, the suspected hematogenous lung abscess was not well controlled and transferred to the respiratory department. The manifestation of involvement was finally confirmed by skin biopsy. Biopsy was performed on the skin of the lower extremities with a dark red rash with multiple microprojections. Pathology indicated neutrophilic infiltration and necrosis of small vessel walls, and granuloma formation. Blood anti‐protease 3 antibody (PR3) was positive Monotherapy with prednisone. Body temperature gradually returned to normal; hemoptysis and nasal bleeding disappeared; parotid gland enlargement and dysuria relieved, and lung cavities gradually reduced. When anti‐infective treatment is ineffective, we should consider the presence of some non‐infectious diseases, especially when multiple systems are involved; biopsy should be performed as soon as possible. Granulomatous polyangiitis has various manifestations. Parotid glands and prostate may also be the first organs involved, not limited to common targets such as the respiratory tract and kidneys.

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Section: Discussionmentioning

confidence: 99%

Granulomatous polyangiitis misdiagnosed as hematogenous lung abscess: A case report

Yang

Chang

2022

Clinical Case Reports

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“…Pathophysiologisch liegt ihr neben einer meist nekrotisierenden Glomerulonephritis eine granulomatöse Entzündung des Respirationstraktes und eine nekrotisierende Vaskulitis kleiner und mittelgroßer Gefäße zugrunde. Der Befall von Niere und Respirationstrakt bestimmt zumeist Beschwerdebild und Prognose der Patienten, grundlegend können jedoch alle Organsysteme vom Entzündungsprozess betroffen sein [8,9,13]. Das zentrale Nervensystem ist in 1-10% der Fälle beteiligt, nur in extrem seltenen Fällen wird ein isolierter Befall der Hirnhäute beobachtet [3,4,15] …”

Section: Introductionunclassified