477 Side-Bias and Time-of-Day Influenced Cognition after Minipigs Were Conditioned Using a Novel Tactile Stimulation Device.

Coffin, Morgan; Manjarín, Rodrigo; Mumm, Jared M.; Bortoluzzi, E; Ruiz, Luis Arturo Haro; Tommerdahl, Mark; Holden, Jameson K.; Walilko, Tim; Zai, Laila; Hulbert, L.E.

doi:10.1093/jas/sky073.474

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“…We have previously reported on the intra-and interobserver reliability of the HAT, and with the additional structural ethograms, reliabilities are similarly high (Pearson's R 2 > 0.90) for duration 6 . Frequency and latency measures require trained observers, whereas duration measures are less observer-dependent, and therefore, more reliable across laboratories 30 .…”

Section: Modifications and Troubleshootingmentioning

confidence: 99%

Noninvasive, In-pen Approach Test for Laboratory-housed Pigs

Hulbert¹,

Bortoluzzi²,

Luo³

et al. 2019

JoVE

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Traumatic brain injury (TBI) incidences have increased in both civilian and military populations, and many researchers are adopting a porcine model for TBI. Unlike rodent models for TBI, there are few behavioral tests that have been standardized. A larger animal requires more invasive handling in test areas than rodents, which potentially adds stress and variation to the animals' responses. Here, the human approach test (HAT) is described, which was developed to be performed in front of laboratory pigs' home pen. It is noninvasive, but flexible enough that it allows for differences in housing set-ups.During the HAT, three behavioral ethograms were developed and then a formula was applied to create an approach index (AI). Results indicate that the HAT and its index, AI, are sensitive enough to detect mild and temporary alterations in pigs' behavior after a mild TBI (mTBI). In addition, although specific behavior outcomes are housing-dependent, the use of an AI reduces variation and allows for consistent measurements across laboratories. This test is reliable and valid; HAT can be used across many laboratories and for various types of porcine models of injury, sickness, and distress. This test was developed for an optimized manual timestamping method such that the observer consistently spends no more than 9 min on each sample.

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Section: Modifications and Troubleshootingmentioning

confidence: 99%