4D-bioprinted silk hydrogels for tissue engineering

Kim, Soon Hee; Seo, Ye Been; Yeon, Yeung Kyu; Lee, Young Jin; Park, Hae Sang; Sultan, Tipu; Lee, Jung Min; Lee, Ji Seung; Lee, Ok Joo; Hong, Heesun; Lee, Hanna; Ajiteru, Olatunji; Suh, Ye Ji; Song, Sung-Hyuk; Lee, Kwang-Ho; Park, Chan Hum

doi:10.1016/j.biomaterials.2020.120281

Cited by 204 publications

(112 citation statements)

References 41 publications

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“…Sacrificial polymers (fugitive inks), are usually applied as temporary support of overhanging structures during 3D bioprinting, and are extensively used to construct microfluidic channels which allows the creation of vascularized tissues [280]. Agarose and gelatin are the most used polymers in sacrificial strategy, where the desired channel cavity into the material is filled with these temporarily polymers during the printing process and are subsequently removed by heating [48,262,263,269]. The surfactant Pluronic F127 can be utilized as a fugitive ink for microfluidic network constructs that can also be removed through temperature [264].…”

Section: D Printing In Tissue Engineeringmentioning

confidence: 99%

“…Materials that are responsive to other stimuli have been developed for use in tissue engineering. Park et al [269] controlled changes in shape of 3D printed bilayer Sil-Ma hydrogels by modulating their properties in physiological conditions through osmolarity. Based on this technique, they constructed a trachea mimetic tissue using two cell types that successfully integrated rabbit damage trachea in vivo.…”

Section: D Printing In Tissue Engineeringmentioning

confidence: 99%

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Bioresorbable Polymers: Advanced Materials and 4D Printing for Tissue Engineering

Saska¹,

Pilatti²,

Blay³

et al. 2021

Polymers

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Three-dimensional (3D) printing is a valuable tool in the production of complexes structures with specific shapes for tissue engineering. Differently from native tissues, the printed structures are static and do not transform their shape in response to different environment changes. Stimuli-responsive biocompatible materials have emerged in the biomedical field due to the ability of responding to other stimuli (physical, chemical, and/or biological), resulting in microstructures modifications. Four-dimensional (4D) printing arises as a new technology that implements dynamic improvements in printed structures using smart materials (stimuli-responsive materials) and/or cells. These dynamic scaffolds enable engineered tissues to undergo morphological changes in a pre-planned way. Stimuli-responsive polymeric hydrogels are the most promising material for 4D bio-fabrication because they produce a biocompatible and bioresorbable 3D shape environment similar to the extracellular matrix and allow deposition of cells on the scaffold surface as well as in the inside. Subsequently, this review presents different bioresorbable advanced polymers and discusses its use in 4D printing for tissue engineering applications.

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Section: D Printing In Tissue Engineeringmentioning

confidence: 99%

Section: D Printing In Tissue Engineeringmentioning

confidence: 99%

Bioresorbable Polymers: Advanced Materials and 4D Printing for Tissue Engineering

Saska¹,

Pilatti²,

Blay³

et al. 2021

Polymers

View full text Add to dashboard Cite

show abstract

“…One limitation of 4D-printed smart materials that has delayed the progress of the technique in regenerative medicine is their biocompatibility [11]. To function successfully in a clinical setting, biomaterials need to reflect the in vivo human tissues that they are intended to repair.…”

Section: Revitalizing Regenerative Medicinementioning

confidence: 99%

“…Integrating two different cell types into the hydrogel the team attempted to replicate a trachea-like structure, which was then implanted into the damaged trachea of a rabbit. After 8 weeks of observation epithelial and cartilage tissues were found to be growing at the intended sites [11].…”

Section: Revitalizing Regenerative Medicinementioning

confidence: 99%

Stay Smart: It’s all about the Materials for 4D Printing in Biomedicine

Free

2021

BioTechniques

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“…A 4D bioprinter can be constructed using a structure under different stimuli over time. The technique has the potential to engineer a more complex construct using stimuli-response biomaterials that can change the shape of the construct over time [197]. Therefore, shape memory polymers-called smart materials-have garnered attention in this field because they enable 4D bioprinting.…”

Section: Limitations and Future Perspectivesmentioning

confidence: 99%

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

Park

Kim

et al. 2020

Polymers

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Three-dimensional (3D) bioprinting technology has emerged as a powerful biofabrication platform for tissue engineering because of its ability to engineer living cells and biomaterial-based 3D objects. Over the last few decades, droplet-based, extrusion-based, and laser-assisted bioprinters have been developed to fulfill certain requirements in terms of resolution, cell viability, cell density, etc. Simultaneously, various bio-inks based on natural–synthetic biomaterials have been developed and applied for successful tissue regeneration. To engineer more realistic artificial tissues/organs, mixtures of bio-inks with various recipes have also been developed. Taken together, this review describes the fundamental characteristics of the existing bioprinters and bio-inks that have been currently developed, followed by their advantages and disadvantages. Finally, various tissue engineering applications using 3D bioprinting are briefly introduced.

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4D-bioprinted silk hydrogels for tissue engineering

Cited by 204 publications

References 41 publications

Bioresorbable Polymers: Advanced Materials and 4D Printing for Tissue Engineering

Bioresorbable Polymers: Advanced Materials and 4D Printing for Tissue Engineering

Stay Smart: It’s all about the Materials for 4D Printing in Biomedicine

Current Advances in 3D Bioprinting Technology and Its Applications for Tissue Engineering

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