2021
DOI: 10.1021/acsami.0c17610
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4D Printed Cardiac Construct with Aligned Myofibers and Adjustable Curvature for Myocardial Regeneration

Abstract: As an innovative additive manufacturing process, 4D printing can be utilized to generate predesigned, self-assembly structures which can actuate time-dependent, and dynamic shape-changes. Compared to other manufacturing techniques used for tissue engineering purposes, 4D printing has the advantage of being able to fabricate reprogrammable dynamic tissue constructs that can promote uniform cellular growth and distribution. For this study, a digital light processing (DLP)-based printing technique was developed t… Show more

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Cited by 112 publications
(100 citation statements)
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References 53 publications
(81 reference statements)
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“…Compared with 3D scaffolds, 4D scaffolds with the ability to reconfigure their shapes during culture show huge potential for morphodynamic tissue engineering. Hydrogels that harness non-uniform swelling [ 43 , 54 , [56] , [57] , [58] ], post-programmed anisotropic internal strains [ 59 , 60 ], or cell contractile forces [ [61] , [62] , [63] ] can accomplish this task. However, in addition to the stringent requirements regarding material cytocompatibility, the fabrication process, and imposed stimulation, complexity in fabrication and lack of controllability present a significant impedance to 4D tissue engineering.…”
Section: Resultsmentioning
confidence: 99%
“…Compared with 3D scaffolds, 4D scaffolds with the ability to reconfigure their shapes during culture show huge potential for morphodynamic tissue engineering. Hydrogels that harness non-uniform swelling [ 43 , 54 , [56] , [57] , [58] ], post-programmed anisotropic internal strains [ 59 , 60 ], or cell contractile forces [ [61] , [62] , [63] ] can accomplish this task. However, in addition to the stringent requirements regarding material cytocompatibility, the fabrication process, and imposed stimulation, complexity in fabrication and lack of controllability present a significant impedance to 4D tissue engineering.…”
Section: Resultsmentioning
confidence: 99%
“…Hoje já existem impressoras 4D, que surgiram a partir da 3D, mas o material produzido "muda" sua forma posteriormente. Além dos aspectos dimensionais, volumétricos e de produção, adiciona-se a função tempo fazendo com que os materiais que antes eram rígidos, sólidos, sem alterações ao longo do tempo, passem a ter sua forma alterada dentro da linha do tempo (Wang et al, 2021b). Estímulos como pressão, temperatura, umidade, luminosamente fazem com que o material impresso mude de forma, função, cor, e até de função (Choi et al, 2015;Shakibania et al, 2021).…”
Section: Resultsunclassified
“…[34] Following up on this work, Wang et al developed a 4D cardiac patch with NIR-light-induced shape memory behavior. [123] To this end, researchers prepared a bioink composed of temperature-responsive shape memory polymers, namely bisphenol A diglycidyl ether (monomers), poly(propylene glycol) bis(2-aminopropyl) ether (crosslinker), and decylamine (crosslinking modulator), along with graphene as an additive nanomaterial. Due to the photothermal effect triggered upon NIR light exposure, this construct was able to change its shape from a flat to a curved [46] Copyright 2021, Ivyspring International Publisher.…”
Section: Cardiac Patchesmentioning
confidence: 99%
“…Adapted with permission. [123] Copyright 2021, ACS Publications. www.advmattechnol.de its potential as a solution for translational TERM applications.…”
Section: Limitations and Future Perspectivesmentioning
confidence: 99%
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