4D synchrotron microtomography and pore-network modelling for direct <i>in situ</i> capillary flow visualization in 3D printed microfluidic channels

Piovesan, Agnese; Looverbosch, Tim Van De; Verboven, Pieter; Achille, Clement; Parra‐Cabrera, Cesar; Boller, Élodie; Cheng, Yin; Ameloot, Rob; Nicolaı̈, Bart

doi:10.1039/d0lc00227e

Cited by 12 publications

(12 citation statements)

References 44 publications

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“…Looking ahead, this connection could lead to the generative digital design of a microfluidic layout based on the desired assay timeline. [ 28,29 ] ii) The 3D‐printing speed (>1000 cm 3 h −1 for a lab‐scale printer) [ 30 ] permits viable fabrication of diagnostics ( ≈ 100 devices h −1 ), thus opening up perspectives on distributed manufacturing. [ 31,32 ] The latter approach could aid capacity building initiatives for diagnostics production in developing countries [ 33 ] and already proved its value in addressing shortages in emergency situations (e.g., protective equipment and respirators during the COVID‐19 pandemic).…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Monolithic Capillarity‐Driven Microfluidic Devices for Diagnostics

et al. 2021

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Rapid diagnostic testing at the site of the patient is essential when a fully equipped laboratory is not accessible. To maximize the impact of this approach, low‐cost, disposable tests that require minimal user‐interference and external equipment are desired. Fluid transport by capillary wicking removes the need for bulky ancillary equipment to actuate and control fluid flow. Nevertheless, current microfluidic paper‐based analytical devices based on this principle struggle with the implementation of multistep diagnostic protocols because of fabrication‐related issues. Here, 3D‐printed microfluidic devices are demonstrated in a proof‐of‐concept enzyme‐linked immunosorbent assay in which a multistep assay timeline is completed by precisely engineering capillary wetting within printed porous bodies. 3D printing provides a scalable route to low‐cost microfluidic devices and obviates the assembly of discrete components. The resulting rapid and seamless transition between digital data and physical objects allows for rapid design iterations, and opens up perspectives on distributed manufacturing.

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Section: Resultsmentioning

confidence: 99%

3D Printing of Monolithic Capillarity‐Driven Microfluidic Devices for Diagnostics

et al. 2021

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“…More recently, porous materials with interconnected pore structures provide an alternative for bioactive agents delivery [481]. The highlighted feature of this capillarity-based wicking process is simple, gentle, and generally independent of the solute in the adsorbed solution [482][483][484]. Inspired by these spongy materials, Ji et al [485,486] have proposed a hierarchical stent coating architecture composed of a drug coating base layer and a porous cap layer for improving the in-stent regeneration of endothelium.…”

Section: Synthetic Polymer Coating With Porous Structurementioning

confidence: 99%

Biomedical polymers: synthesis, properties, and applications

Chen

et al. 2022

Sci. China Chem.

119

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Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

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“…Several approaches have been investigated to find an alternate pumping mechanism that does not require a mechanical actuator and power source. Examples include unconventional approaches like capillary fluid flow [6][7][8] or stimuli-responsive actuators. [9][10][11][12][13] In gel-based actuators, the flow has been achieved via periodic expansion and contraction of the gel.…”

Section: Introductionmentioning

confidence: 99%

Polymer multilayer films regulate macroscopic fluid flow and power microfluidic devicesviasupramolecular interactions

Alam¹,

Gill²,

Varshney³

et al. 2022

Soft Matter

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4D synchrotron microtomography and pore-network modelling for direct in situ capillary flow visualization in 3D printed microfluidic channels

Abstract: We investigate fluid flow at the pore scale in novel 3D printed microfluidic channels through synchrotron microtomography and pore-network modelling.

Cited by 12 publications

References 44 publications

3D Printing of Monolithic Capillarity‐Driven Microfluidic Devices for Diagnostics

3D Printing of Monolithic Capillarity‐Driven Microfluidic Devices for Diagnostics

Biomedical polymers: synthesis, properties, and applications

Polymer multilayer films regulate macroscopic fluid flow and power microfluidic devicesviasupramolecular interactions

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