A photothermal bacterium (PTB) is reported for tumor‐targeted photothermal therapy (PTT) by using facultative anaerobic bacterium Shewanella oneidensis MR‐1 (S. oneidensis MR‐1) to biomineralize palladium nanoparticles (Pd NPs) on its surface without affecting bacterial activity. It is found that PTB possesses superior photothermal property in near infrared (NIR) regions, as well as preferential tumor‐targeting capacity. Zeolitic imidazole frameworks‐90 (ZIF‐90) encapsulating photosensitizer methylene blue (MB) are hybridized on the surface of living PTB to further enhance PTT efficacy. MB‐encapsulated ZIF‐90 (ZIF‐90/MB) can selectively release MB at mitochondria and cause mitochondrial dysfunction by producing singlet oxygen (1O2) under light illumination. Mitochondrial dysfunction further contributes to adenosine triphosphate (ATP) synthesis inhibition and heat shock proteins (HSPs) down‐regulated expression. The PTB‐based therapeutic platform of PTB@ZIF‐90/MB demonstrated here will find great potential to overcome the challenges of tumor targeting and tumor heat tolerance in PTT.

By leveraging the ability of Shewanella oneidensis MR-1 (S.oneidensis MR-1) to anaerobically catabolize lactate through the transfer of electrons to metal minerals for respiration, al actate-fueled biohybrid (Bac@MnO 2)w as constructed by modifying manganese dioxide (MnO 2)n anoflowers on the S. oneidensis MR-1 surface.T he biohybrid Bac@MnO 2 uses decorated MnO 2 nanoflowers as electron receptor and the tumor metabolite lactate as electron donor to make ac omplete bacterial respiration pathway at the tumor sites,which results in the continuous catabolism of intercellular lactate.A dditionally,d ecorated MnO 2 nanoflowers can also catalyze the conversion of endogenous hydrogen peroxide (H 2 O 2)into generate oxygen (O 2), which could prevent lactate production by downregulating hypoxia-inducible factor-1a (HIF-1a)e xpression. As lactate playsacritical role in tumor development, the biohybrid Bac@MnO 2 could significantly inhibit tumor progression by coupling bacteria respiration with tumor metabolism.

This review provides a comprehensive introduction to microorganisms-based biohybrid systems, namely MAMO, for application in tumor therapeutics.

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

Marrow adipogenesis is synchronized with bone loss in the development of GIOP, which was characterized by a significant increase in the number of small-sized marrow adipocytes in the relatively early stage and concomitant volume increase later on. MR spectroscopy appears to be the most powerful tool for detecting the sequential changes in marrow lipid content.