Customized materials-assisted microorganisms in tumor therapeutics

Chen, Qi‐Wen; Qiao, Jiyan; Liu, Xinhua; Zhang, Cheng; Zhang, Xian‐Zheng

doi:10.1039/d0cs01571g

Cited by 62 publications

(43 citation statements)

References 391 publications

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“… 48 , 50 , 78 Although the anticancer mechanism associated with microalgae extracts is complex, it can be generalized into cancer-cell killing and immune-modulation effects. 15 …”

Section: Treatment Of Oxygen Deficiency Aggravated Diseasesmentioning

confidence: 99%

“…Microalgae are a diverse group of unicellular prokaryotic and eukaryotic organisms that are widespread in nature, and can be used for mitigating hypoxia. 15 Microalgae are approximately 2–10 μm in size and are composed of lipids, proteins, nucleic acids, and carbohydrates. Unlike many other microorganisms, they are also considered excellent sources of various bioactive compounds, such as antioxidants, vitamins, and minerals.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, microalgae are considered oxygen generators. 15 , 19 They have excellent biocompatibility and bioactivity and do not exhibit significantly high aggressive behavior toward mammalian cells (except known species of toxic microalgae). Thus, microalgae have broad potential for use in the biomedical field.…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the microalgae research field has grown, and reviews in this field have been published. 15 , 20 Some of these reviews focus on the field of tumor treatment, but there is no existing review of other hypoxic diseases like ischemic heart disease and wound healing. In this review, we summarize the current progress made in customized microalgae-based biomaterials that can be used to develop therapeutics to treat ODAD ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

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How Microalgae is Effective in Oxygen Deficiency Aggravated Diseases? A Comprehensive Review of Literature

Cui¹,

Su²,

Wei³

et al. 2022

IJN

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Hypoxia can aggravate the conditions of many oxygen-deficiency-aggravated diseases (ODAD), such as cancer, ischemic heart disease, and chronic wounds. Photosynthetic microalgae can alleviate the hepatotoxicity of the local microenvironment by producing oxygen. In addition, microalgae extracts have antitumor, anti-inflammatory, antibacterial, and antioxidant effects. These properties make them attractive candidates for developing methods to treat ODAD. Although researchers have exploited the advantages of microalgae and developed a variety of microalgae-based biomaterials to treat ODAD, a comprehensive review of this topic has not been presented previously. Therefore, in this review, we summarize the development and progress made in the field of developing microalgae-based biomaterials toward the treatment of ODAD. The challenges and prospects of this field are also discussed.

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“… 48 , 50 , 78 Although the anticancer mechanism associated with microalgae extracts is complex, it can be generalized into cancer-cell killing and immune-modulation effects. 15 …”

Section: Treatment Of Oxygen Deficiency Aggravated Diseasesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

How Microalgae is Effective in Oxygen Deficiency Aggravated Diseases? A Comprehensive Review of Literature

Cui¹,

Su²,

Wei³

et al. 2022

IJN

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show abstract

“…Recently, by uniting the alive traits of microorganisms with the versatile properties of functional materials, the customized materials‐assisted microorganisms (MAMO) were well fabricated, [ 16 ] and emergingly applied in biosensing, [ 17 ] self‐repairing and regeneration, [ 18 ] protein production, [ 19 ] antipathogens, and diseases treatment. [ 20 ] Particularly, by utilizing the unique ability of microorganisms, many intractable diseases have the chance to be well treated, including kidney failure, [ 21 ] colon cancer, [ 22 ] colitis, [ 23 ] and alcoholic liver disease, [ 24 ] etc.…”

Section: Introductionmentioning

confidence: 99%

Hierarchy‐Assembled Dual Probiotics System Ameliorates Cholestatic Drug‐Induced Liver Injury via Gut‐Liver Axis Modulation

Chen

Cao

et al. 2022

Advanced Science

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Cholestatic drug‐induced liver injury (DILI) induced by drugs or other xenobiotics is a severe and even fatal clinical syndrome. Here, living materials of hierarchy‐assembled dual probiotics system are fabricated by sequentially encapsulating probiotic Lactobacillus delbrueckii subsp. bulgaricus (LDB) and Lactobacillus rhamnosus GG (LGG) into Ca2+‐complexed polymer microspheres for effective prevention of cholestatic DILI. Upon entering intestinal tract of the constructed living materials, LGG is released because of pH‐triggered dissolution of outer enteric polymer coating. The released LGG can inhibit hepatic bile acids (BAs) synthesis by activating intestinal farnesoid X receptor‐fibroblast growth factor 15（FGF‐15) signaling pathway. BAs excretion is also facilitated by LGG through increasing the abundance of bile salt hydrolase (BSH)‐active gut commensal bacteria. Furthermore, exposed positively‐charged chitosan shell can absorb the excessive BAs via electrostatic interaction, which leads to steady BAs fixation by the imprisoned LDB, decreasing the total BAs amounts in enterohepatic circulation. Together, the fabricated living materials, obtained here, can effectively prevent cholestatic DILI through dredging cholestasis via gut‐liver axis modulation. The therapeutic effect is demonstrated in α‐naphthylisothiocyanate and clinical antiepileptic drug valproate acid‐induced cholestatic DILI mouse models, which reveal the great potential for effective cholestatic DILI management.

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Time‐Responsive Activity of Engineered Bacteria for Local Sterilization and Biofilm Removal in Periodontitis

Bai,

Guo,

Hua

et al. 2024

Adv Healthcare Materials

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Periodontitis is a highly prevalent and common condition in people of all ages, however, existing drugs to treat periodontitis have difficulty penetrating complex biofilms. Here, we report a biofilm‐penetrating probiotic hybrid strategy for the treatment of periodontitis. It consists of therapeutic probiotics of E. coli Nissle 1917, which can produce antimicrobial peptides and hydrogen, and is coated with D‐amino acids that can penetrate biofilms. After the fusion of D‐amino acids with the biofilm, EcN entered the plaque biofilm and produced antimicrobial peptides to kill porphyromonas gingivalis and eliminate periodontitis under the action of hydrogen. The efficacy of EcN@DA‐D in biofilm penetration and treatment of periodontitis was demonstrated in a rat model of periodontitis. In addition, the clinical combination to construct a rat periodontitis model by using clinical tissue has a significant therapeutic effect. In conclusion, EcN@DA‐D offers a promising topical treatment for periodontitis without developing detectable pathogen resistance and side effects.

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Customized materials-assisted microorganisms in tumor therapeutics

Abstract: This review provides a comprehensive introduction to microorganisms-based biohybrid systems, namely MAMO, for application in tumor therapeutics.

Cited by 62 publications

References 391 publications

How Microalgae is Effective in Oxygen Deficiency Aggravated Diseases? A Comprehensive Review of Literature

How Microalgae is Effective in Oxygen Deficiency Aggravated Diseases? A Comprehensive Review of Literature

Hierarchy‐Assembled Dual Probiotics System Ameliorates Cholestatic Drug‐Induced Liver Injury via Gut‐Liver Axis Modulation

Time‐Responsive Activity of Engineered Bacteria for Local Sterilization and Biofilm Removal in Periodontitis

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