4MBC and OMC, components of UV-sunscreens, exert organ specific alterations on type I 5'-Deiodinase activity and expression in female rats

Hamann, I.; Hofmann, Peter; Schmutzler, Cornelia; Mentrup, Birgit; Huhne, K.; Jarry, Hubertus; Seidlová-Wuttke, Dana; Wuttke, W.; Köhrle, Josef

doi:10.1055/s-2005-862997

Cited by 3 publications

(3 citation statements)

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“…In the kidney ( Hamann et al 2005 ), there was a significant increase in 5′DI activity triggered by E 2 (about 1.5-fold) in contrast to the liver. OMC and 4-MBC both reduced 5′DI activity significantly (to < 50%).…”

Section: Ex Vivo Assaysmentioning

confidence: 99%

Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New Biomarkers

Schmutzler

Gotthardt

Hofmann

et al. 2007

Environ Health Perspect

137

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BackgroundThere is growing evidence that, in addition to the reproductive system, the hypothalamic–pituitary–thyroid axis is a target of endocrine-disrupting compounds (EDCs). However, this is not reflected adequately in current screening and assessment procedures for endocrine activity that to date determine only general parameters of thyroid function.Objective and MethodsWe used several in vitro and ex vivo assays in an attempt to identify suitable biomarkers for antithyroid action testing a selected panel of putative EDCs.ResultsIn vitro we detected stimulation or inhibition of iodide uptake into FRTL-5 rat thyroid cells, inhibition of thyroid hormone binding to transthyretin, agonistic or antagonistic effects in a thyroid hormone receptor–dependent reporter assay, and inhibition of thyroid peroxidase using a novel assay system based on human recombinant thyroperoxidase that might be suitable for routine screening for potential EDCs. In rats, chronic application of several EDCs led to changes in thyroid morphology, alterations of thyrotropin and thyroid hormone serum levels as well as alterations in peripheral thyroid hormone–regulated end points such as malic enzyme and type I 5′-deiodinase activity.ConclusionsAs the effects of EDCs do not reflect classic mechanisms of hormone-dependent regulation and feedback, we believe multitarget and multimodal actions of EDCs affect the hypothalamic–pituitary–thyroid axis. These complex effects require a diverse approach for screening, evaluation, and risk assessment of potential antithyroid compounds. This approach involves novel in vitro or cell-based screening assays in order to assess thyroid hormone synthesis, transport, metabolism, and action as well as in vivo assays to measure thyroid hormone–regulated tissue-specific and developmental end points in animals.

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Section: Ex Vivo Assaysmentioning

confidence: 99%

Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New Biomarkers

Schmutzler

Gotthardt

Hofmann

et al. 2007

Environ Health Perspect

137

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“…TPO activity was unaltered but T3-responsive hepatic type I 5′ deiodinase activity was reduced by OMC. OMC was found exerting effects on the TH axis by using female ovariectomized rats [ 83 ]. OMC affected TH via inhibition of type I 5′-Deiodinase activity and gene expression.…”

Section: Endocrine Disrupting Effects Of Typical Uv Filtersmentioning

confidence: 99%

Recent Advances on Endocrine Disrupting Effects of UV Filters

Wang

Pan

et al. 2016

IJERPH

145

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Ultraviolet (UV) filters are used widely in cosmetics, plastics, adhesives and other industrial products to protect human skin or products against direct exposure to deleterious UV radiation. With growing usage and mis-disposition of UV filters, they currently represent a new class of contaminants of emerging concern with increasingly reported adverse effects to humans and other organisms. Exposure to UV filters induce various endocrine disrupting effects, as revealed by increasing number of toxicological studies performed in recent years. It is necessary to compile a systematic review on the current research status on endocrine disrupting effects of UV filters toward different organisms. We therefore summarized the recent advances on the evaluation of the potential endocrine disruptors and the mechanism of toxicity for many kinds of UV filters such as benzophenones, camphor derivatives and cinnamate derivatives.

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“…These actions can directly affect the gland and/or the corresponding regulatory centers, such as the hypothalamus and the pituitary, affecting the levels of thyrotropin releasing hormone (TRH) and/or thyroidstimulating hormone (TSH), which are directly related to the synthesis of thyroid hormones. Most studies have focused on the estrogenic and anti-androgenic effects of OMC in wild and lab animals (12-14); however only a few studies focused on the influence of OMC upon the HPT function (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Exposure to the UV Filter Octyl Methoxy Cinnamate in the Postnatal Period Induces Thyroid Dysregulation and Perturbs the Immune System of Mice

et al. 2020

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Evidence demonstrates the bidirectional communication and regulation between the neuroendocrine and immune systems. Thyroid hormones play key roles in nervous system development and can exert influence on various immune cells contributing to pathophysiological conditions. Octyl methoxycinnamate (OMC) is one of the most commonly used UV filters, and in vitro and in vivo studies have found thyroid disrupting effects. The present study assessed whether OMC administration in mice dams during the lactational period can cause thyroid disruption and generate immunologic alterations in the offspring. Indirect exposure to the OMC (1,000 mg/kg) in the lactational period affected neurodevelopment parameters, such as delayed eye-opening and weight gain in mice of both sexes, and these alterations are corroborated by the decrease in the T4 levels present in the pups' blood. No significant changes were observed in the thymus of these pups, but the number of lymphocytes increased in the spleen of the animals exposed to OMC, similar to the animals treated with propyl-thiouracil (PTU), a well-known thyroid disruptor. OMC modulated the percentage of leukocyte populations in peripheral blood, and the number of circulating polymorphonuclear cells increased twofold. In vitro, OMC exhibited an inhibitory effect on splenocyte proliferation and IL-2 production induced by anti-CD3 antibody; however, this effect was reversed with the addition of T4 in the cell culture. In summary, the results of the present study demonstrate the influence of OMC on thyroid dysregulation and its impact on the modulation of the immune system in mice pups.

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4MBC and OMC, components of UV-sunscreens, exert organ specific alterations on type I 5'-Deiodinase activity and expression in female rats

Cited by 3 publications

References 0 publications

Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New Biomarkers

Endocrine Disruptors and the Thyroid Gland—A Combined in Vitro and in Vivo Analysis of Potential New Biomarkers

Recent Advances on Endocrine Disrupting Effects of UV Filters

Exposure to the UV Filter Octyl Methoxy Cinnamate in the Postnatal Period Induces Thyroid Dysregulation and Perturbs the Immune System of Mice

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