5-alkylvinyl-1,2,4-triazole nucleosides: Synthesis and biological evaluation

5‐Substituted 1,2,4‐Triazole‐3‐Carboxylates and 5‐Substituted Ribavirin Analogs Synthesis

“…The reaction features and main approaches to the analytical identification of products have been described elsewhere (Prutkov, Chudinov, Matveev, Grebenkina, & Berezovskaya, 2019). Synthesized according to the Basic Protocol 2, ethyl 5‐(benzyloxymethyl)‐1‐(2′,3′,5′‐tri‐ O ‐acetyl‐β‐ D ‐ribofuranosyl)‐1,2,4‐trizole‐3‐carboxylate 7d is a convenient precursor for the preparation of ribavirin analogs with an unsaturated group in the fifth position of triazole ring (Chudinov et al., 2016; Prutkov et al., 2020) (Fig. 4).…”

“…These protocols make it possible to synthesize ribavirin analogs with 5‐alkyl/aryl/oxymethyl substituents and some 5‐heterocyclyl derivatives. We also provide ethyl 5‐(benzyloxymethyl)‐1‐(2′,3′,5′‐tri‐ O ‐acetyl‐β‐ D ‐ribofuranosyl)‐1,2,4‐triazole‐3‐carboxylate as a convenient precursor for the preparation of 5‐arylethenyl and 5‐alkylethenyl analogs of ribavirin, the synthesis of which was described earlier (Chudinov et al., 2016; Prutkov et al., 2020).…”