5‐Aminolevulinic acid‐based photodynamic therapy

Peng, Qian; Warloe, Trond; Berg, Kristian; Moan, Johan Emelian; Kongshaug, Magne; Giercksky, Karl‐Erik; Nesland, Jahn M.

doi:10.1002/(sici)1097-0142(19970615)79:12<2282::aid-cncr2>3.3.co;2-0

Cited by 28 publications

(9 citation statements)

References 18 publications

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“…First, visible light with a longer wavelength allows deeper tissue penetration, but light does not need to reach the deep tissues because PA is generally found on the ulcer surface [36]. Second, 410 nm is the wavelength that achieves maximum excitation of PpIX, which is 30-times greater at this wavelength than 630 nm, so a stronger effect of PDT was anticipated [37]. Based on the above, PDT with 410-nm LED irradiation after treatment with both EDTA-2Na and ALA exhibited a bactericidal effect on PA. Wardlaw et al demonstrated a bactericidal effect of PDT with 0.5 mM ALA and 635 nm laser light at 108 J/cm 2 , whereas Fotinos et al exhibited an in vitro bactericidal effect of PDT with ALA (0.1-10 mM) and 635 nm laser light at 120 J/ cm 2 on PA [38,39].…”

Section: Discussionmentioning

confidence: 94%

Enhanced sterilization and healing of cutaneous pseudomonas infection using 5-aminolevulinic acid as a photosensitizer with 410-nm LED light

Katayama

Ozawa

Morimoto

et al. 2018

Journal of Dermatological Science

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Section: Discussionmentioning

confidence: 94%

Enhanced sterilization and healing of cutaneous pseudomonas infection using 5-aminolevulinic acid as a photosensitizer with 410-nm LED light

Katayama

Ozawa

Morimoto

et al. 2018

Journal of Dermatological Science

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“…Use of ALA-PDT for nodular BCC generally appears less effective, with a weighted clearance rate of 53% for 12 studies treating 208 tumors. 21 Prior debulking curettage or treatment fractionation, with 2 treatments 7 days apart, appears to improve response of nodular BCC to ALA-PDT, with response rates of 92% and 96%, respectively. 22,23…”

Section: and A Therapy For Photoaging As Well?mentioning

confidence: 99%

“…low-up periods of 3 to 36 months, was 87% for 12 studies treating 826 superficial BCCs. 21 For tumors up to 1 mm thick, initial clearances of 81% to 100% are reported after 1 or 2 treatments. 10 Lesions estimated by pretreatment biopsy to be less than 2 mm thick may respond especially well to topical PDT.…”

Section: and A Therapy For Photoaging As Well?mentioning

confidence: 99%

Photodynamic Therapy for Nonmelanoma Skin Cancer—and More?

Morton¹

2004

Arch Dermatol

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HOTODYNAMIC THERAPY (PDT) INVOLVES THE activation of a photosensitizing drug by visible light to produce reactive oxygen species within target cells, resulting in their destruction. Systemic photosensitization and endoscopic light delivery has permitted the treatment of many hollow organ tumors by PDT, including those in the esophagus, stomach, bronchus, and bladder, curing early superficial disease and palliating late disease. 1 Several countries now have approved systemic PDT for these indications. Ease of light delivery to the skin makes PDT an attractive potential therapy for dermatologic conditions. Moreover, the development of topically active agents for PDT avoids the generalized photosensitivity that follows systemic photosensitizer use.

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“…9 Large series of BCCs treated with 5-aminolevulinic acid PDT show complete response rates of 34% to 100%, with inferior clearance in nodular compared with superficial BCC. 10 Routine double PDT treatment may improve procedure efficacy. 11 Methyl aminolevulinate, the methyl ester of 5-aminolevulinic acid, may offer advantages over 5-aminolevulinic acid in terms of improved skin penetration because of enhanced lipophilicity 12,13 and specificity for neoplastic cells.…”

mentioning

confidence: 99%