5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism

Huang, Ling; Zheng, Junping; Sun, Guangjun; Yang, Huabing; Sun, Xiongjie; Lin, Ai Jeng; Hu, Haiming

doi:10.1007/s00018-022-04471-3

Cited by 55 publications

(41 citation statements)

References 62 publications

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“…Therefore, impaired water reabsorption may be the primary cause of diarrhoea. This view is supported by research conducted by Huang et al [ 10 ], who reported that the mRNA expression of ENaC and AQP s was downregulated in the DSS-induced mouse colon.…”

Section: Discussionmentioning

confidence: 56%

“…An in vitro study indicated that continuous DSS exposure led to a decrease in mucus thickness and an increased permeability of mouse colon tissue, allowing the bacteria to elicit inflammation through close contact with epithelial cells [ 8 ]. Goblet cell loss, epithelial cell disruption, crypt structure damage, and inflammatory cell infiltration are also common phenomena observed in DSS-induced colitis [ 9 , 10 ]. In addition, DSS downregulated the expression of tight junction proteins, impairing the intestinal mechanical barrier [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…For example, butyrate and butyrate-producing bacteria play a critical role in anti-inflammation, and their concentrations and relative abundance significantly decrease after DSS induction [ 7 , 9 ]. Moreover, bile acid metabolism dysbiosis, indicated by primary bile acid accumulation and secondary bile acid depletion, is closely related to DSS-induced intestinal inflammation progression [ 10 , 15 ]. The aforementioned studies suggest that intestinal barrier dysfunction is the primary cause of DSS-induced intestinal inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium

Liu

Sui

Ya-jin

et al. 2022

Animals

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This study aimed to evaluate the effectiveness of oral gavage of dextran sodium sulfate (DSS) to establish an enteric inflammation model in broilers. Forty 1-day-old male, yellow-feathered broilers were randomly divided into 2 groups with 5 replicates of 4 birds each for a 42-day trial. The experiment design used 2 groups: (1) the control group (CT), normal broilers fed a basal diet, and (2) the DSS group, DSS-treated broilers fed a basal diet. The DSS group received 1 mL of 2.5% DSS solution once a day by oral gavage from 21 to 29 days of age. The results showed that compared with those in CT, DSS treatment significantly increased histological scores for enteritis and mucosal damage at 29 and 42 days of age (p < 0.01) and the disease activity index (DAI) from 23 to 29 days of age (p < 0.01). DSS-treated broilers showed poor growth performance at 42 days of age, including decreased body weight and average daily gain and an increased feed conversion ratio (p < 0.01). DSS also caused gross lesions and histopathological damage in the jejunum of broilers, such as obvious hemorrhagic spots, loss of villus architecture, epithelial cell disruption, inflammatory cell infiltration, and decreased villus height. These results suggest that oral gavage of DSS is an effective method for inducing mild and non-necrotic enteric inflammation in broilers.

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Section: Discussionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium

Liu

Sui

Ya-jin

et al. 2022

Animals

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“…Of note, bloody stool and loose stool were commonly observed in the IBD mice, but disappeared rapidly after being dosed with PIDA nanofibers (Figure S27). The overtime change of disease activity index (DAI), a parameter that comprehensively reflects the disease severity of the mice, further demonstrated the advantage of PIDA over RIF in IBD treatment (Figure d). Although the body weight of most mice returned to normal on day 9, their colon lengths and fecal quality were still in a condition worse than the mice in the Control group (Figure e,f).…”

Section: Resultsmentioning

confidence: 90%

“…The body weight, anal bleeding, and stool consistency of mice were recorded every other day during the animal experiment. The DAI was determined by combining weight loss with the scores of anal bleeding and stool consistency, which were calculated based on a scoring system . Briefly, each score was determined as following: 1) no loss of body weight was scored as 0, 1 point for 1–5% weight loss, 2 points for 6–10%, 3 points for 11–15%, and 4 points for >15%; 2) no blood was scored as 0 and gross bleeding was scored as 4 points; 3) well-formed stool pellets were scored as 0 and liquid stools were scored as 4 points ( n = 4 biologically independent samples).…”

Section: Methodsmentioning

confidence: 99%

Targeted Computed Tomography Visualization and Healing of Inflammatory Bowel Disease by Orally Delivered Bacterial-Flagella-Inspired Polydiiododiacetylene Nanofibers

et al. 2023

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Accurate diagnosis and timely therapeutic intervention of inflammatory bowel disease (IBD) is essential in preventing the progression of the disease, although it still represents an insurmountable challenge. Here we report the design of bacterial-flagella-inspired polydiiododiacetylene (PIDA) nanofibers and its performance in targeted computed tomography (CT) imaging and on-demand therapeutic intervention of IBD. With a morphology mimicking bacterial flagella, PIDA nanofibers attach on the mucus layer of the gastrointestinal (GI) tract after oral administration, evenly distributing on the GI surface to portray the GI lining under CT scan within 2 h. PIDA can retain for a longer time in the damaged mucosa at the inflamed lesions than in normal GI tissues to enable the targeted CT visualization of IBD. PIDA also scavenges reactive oxygen species and ameliorates gut dysbiosis attributed to its iodine-substituted polydiacetylene structure, so that the enriched PIDA nanofibers at the targeted IBD lesions can alleviate the inflammation while maintaining the gut microbiota homeostasis, thus promoting the rebalance of GI microenvironment and the mucosal healing.

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16S rRNA gene sequencing reveals altered gut microbiota in young adults with schizophrenia and prominent negative symptoms

Chen,

Yu,

Xue

et al. 2024

Brain and Behavior

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BackgroundGut dysbiosis has been established as a characteristic of schizophrenia (SCH). However, the signatures regarding SCH patients with prominent negative symptoms (SCH‐N) in young adults have been poorly elucidated.MethodsStool samples were obtained from 30 young adults with SCH‐N, 32 SCH patients with prominent positive symptoms (SCH‐P) along with 36 healthy controls (HCs). Microbial diversity and composition were analyzed by 16S rRNA gene sequencing. Meanwhile, psychiatric symptoms were assessed by the positive and negative syndrome scale (PANSS).ResultsThere is a significant difference in β‐diversity but not α‐diversity indexes among the three groups. Moreover, we found a higher abundance of Fusobacteria and Proteobacteria phyla and a lower abundance of Firmicutes phyla in SCH‐N when compared with HC. Besides, we identified a diagnostic potential panel comprising six genera (Coprococcus, Monoglobus, Prevotellaceae_NK3B31_group, Escherichia‐Shigella, Dorea, and Butyricicoccus) that can distinguish SCH‐N from HC (area under the curve = 0.939). However, the difference in microbial composition between the SCH‐N and SCH‐P is much less than that between SCH‐N and the HC, and SCH‐N and SCH‐P cannot be effectively distinguished by gut microbiota.ConclusionThe composition of gut microbiota was changed in the patients with SCH‐N, which may help in further understanding of pathogenesis in young adults with SCH‐N.

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5-Aminosalicylic acid ameliorates dextran sulfate sodium-induced colitis in mice by modulating gut microbiota and bile acid metabolism

Cited by 55 publications

References 62 publications

Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium

Establishment of an Enteric Inflammation Model in Broiler Chickens by Oral Administration with Dextran Sulfate Sodium

Targeted Computed Tomography Visualization and Healing of Inflammatory Bowel Disease by Orally Delivered Bacterial-Flagella-Inspired Polydiiododiacetylene Nanofibers

16S rRNA gene sequencing reveals altered gut microbiota in young adults with schizophrenia and prominent negative symptoms

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