5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis

Sutherland, Lloyd R.; Martin, François; Greer, Scott; Robinson, Malcolm; Greenberger, Norton J.; Saibil, Fred; Martin, Thomas J.; Sparr, Joseph; Prokipchuk, E J; Borgen, Lowell A.

doi:10.1016/0016-5085(87)90621-4

Cited by 638 publications

(345 citation statements)

References 9 publications

Supporting

Mentioning

335

Contrasting

Unclassified

Order By: Relevance

“…However, an extreme, ly large patient population was assessed. These results clearly support 4 g 5-ASA enemas as effective treatment of distal ulcerative colitis and are consistent with results of smaller, placebo controlled, double-blind studies (7,9).…”

Section: Discussionsupporting

confidence: 86%

“…At each of these assessments, the disease activity index was measured. The disease activity index (Table l) represents an attempt to provide objective criteria for assessment of drug efficacy and has been used in previous studies (9). Four variables arc assessed: stool frequency, rectal bleeding, sigmoidoscopic appearance of mucosa and physician's assessment of disease severity.…”

Section: Methodsmentioning

confidence: 99%

“…Although there was some absorption across the inflamed mucosa, urinary excretion accounted for only 15% of the adm inistered dose (5,6). Various relatively small, controlled studies have supported the safety and efficacy of 5-ASA enemas in the treatment of distal ulcerative colitis and proctitis (7)(8)(9)(10). The aim of the present study was to evaluate further the efficacy and tolerance of t he 5-ASA formulation, Rowasa (Reid-Rowell, Georgia) in a large patient population.…”

Section: Oklahoma Foundation For Digestive Research Oklahomamentioning

confidence: 99%

See 2 more Smart Citations

Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis

Mg¹,

Decktor²

1990

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

The efficacy of 4 g 5-aminosalicylic acid (5-ASA, mesalamine) enemas was assessed in 666 patients with distal ulcerative colitis. Patients were enrolled in an open-label compassionate use program. One 4 g 5-ASA enema was administered each night for a period of four weeks and the disease activiry index was assessed at baseline and on days 14 and 28. On days 14 and 28, 78.0% and 88.1 % of patients, respectively, demonstrated an improvement in disease activiry index. The mean decline in disease activiry index on day 14 was 40. 7% (P=0.0001) and on day 28 it was 55.4% (P=0.0001). Efficacy was similar whether the disease was confined to or extended beyond 30 cm from the anus. There was no difference in efficacy in patients suffering their first episode of disease compared to patients suffering subsequent attacks.

show abstract

Section: Discussionsupporting

confidence: 86%

Section: Methodsmentioning

confidence: 99%

Section: Oklahoma Foundation For Digestive Research Oklahomamentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis

Mg¹,

Decktor²

1990

Canadian Journal of Gastroenterology

View full text Add to dashboard Cite

show abstract

“…The St. Marks index 8 and the ulcerative colitis disease-activity index 11 provide an assessment of disease activity based on a combination of symptoms, signs, and sigmoidoscopic findings, with scores ranging from 0 to 12 and 0 to 22, respectively. In both cases, lower scores mean less disease activity.…”

Section: Clinical Scoring and Definition Of Remissionmentioning

confidence: 99%

Epidermal Growth Factor Enemas with Oral Mesalamine for Mild-to-Moderate Left-Sided Ulcerative Colitis or Proctitis

et al. 2003

View full text Add to dashboard Cite

Epidermal growth factor enemas with oral mesalamine for mild-tomoderate left-sided ulcerative colitis or proctitis Sinha, A; Nightingale, JMD; West, KP; Berlanga-Acosta, J; Playford, RJ For additional information about this publication click this link.https://qmro.qmul.ac.uk/jspui/handle/123456789/224 Information about this research object was correct at the time of download; we occasionally make corrections to records, please therefore check the published record when citing. For more information contact scholarlycommunications@qmul.ac.uk original articleThe new england journal of medicine n engl j med 349;4 www.nejm.org

show abstract

“…Patients were evaluated at study entry (using a 3-day baseline period) and after 4 weeks, according to a previously described 13-point disease activity index which measured stool frequency, rectal bleeding, sigmoidoscopic ®ndings, and physician's global assessment. 15,16 Clinical remission was de®ned as a disease activity index score = 0. Clinical improvement in the absence of remission was de®ned as a decrease in the disease activity index greater than or equal to three points.…”

Section: Measurement Of Clinical Disease Activitymentioning

confidence: 99%

Nicotine tartrate liquid enemas for mildly to moderately active left‐sided ulcerative colitis unresponsive to first‐line therapy: a pilot study

Sandborn

Tremaine

Leighton

et al. 1997

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Ulcerative colitis is primarily a disease of non-smokers. 1±3 Two-thirds of ex-smokers with ulcerative colitis SUMMARY Background: Ulcerative colitis is predominantly a disease of non-smokers, and transdermal nicotine is therapeutic but often results in side-effects. Administration of nicotine as a liquid rectal enema results in less systemic nicotine absorption. Aim: To determine the safety and clinical response of nicotine tartrate liquid enemas for active left-side ulcerative colitis in a pilot study. Methods: Ten non-smoking patients with mildly to moderately active left-sided ulcerative colitis unresponsive to ®rst-line therapy were treated in an open protocol with nightly nicotine tartrate liquid enemas at a dose of 3 mg nicotine base for 1 week then 6 mg for 3 weeks. Clinical assessments were determined at baseline and 4 weeks by endoscopy, physician assessment and a patient diary of daily symptoms. Peak and trough serum nicotine and trough plasma cotinine were determined by gas chromatography/mass spectrometry and high performance liquid chromatography, respectively. Results: After 4 weeks of treatment, 5/7 patients (71%) showed clinical and sigmoidoscopic improvement (per

show abstract

5-Aminosalicylic acid enema in the treatment of distal ulcerative colitis, proctosigmoiditis, and proctitis

Cited by 638 publications

References 9 publications

Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis

Efficacy of 5-Aminosalicylic Acid Enemas in the Treatment of Distal Ulcerative Colitis

Epidermal Growth Factor Enemas with Oral Mesalamine for Mild-to-Moderate Left-Sided Ulcerative Colitis or Proctitis

Nicotine tartrate liquid enemas for mildly to moderately active left‐sided ulcerative colitis unresponsive to first‐line therapy: a pilot study

Contact Info

Product

Resources

About