5-Bis-(2-Chloroethyl)-Aminouracil, a New Antitumor Agent

Treatment of Leukaemias and Reticuloses with Uracil Mustard

“…The search for an equally efficient oral substitute for the intravenously administered nitrogen mustards, such as tri-(2-chlorethyl)amine hydrochloride, has led to the trial of a new substance, 5-di-(2-chlorethyl)aminouracil (uracil mustard), that had been synthesized by Lyttle and Petering (1958).…”

“…Uracil mustard is a white crystalline substance that can be given orally with minimal toxic side-effects. It was shown by Evans and Mengel (1958), Lyttle and Petering (1959), and Lane and Kelly (1960) to be active against various tumours in small animals, and its anti-tumour effects against malignant disease were reported by Lane andKelly (1959a, 1959b), by Lane et al (1960), and by Vaitkevicius et al (1961 Messrs. Upjohn Ltd. through Dr. R. G. Jacomb, and we have been able to carry out a trial of its value in the treatment of chronic myeloid and lymphatic leukaemias, Hodgkin's disease and other reticuloses, lymphomata, and malignant diseases. This is a brief preliminary report of a four-year trial.…”

“…More recently, however, Lyttle and Petering (1958), by introducing the uracil grouping into the molecule of tri-(2-chlorethyl)amine, synthesized 5-di-(2-chlorethyl)aminouracil (uracil mustard, or U8344), a substance that could be given orally to patients, producing results almost identical to those obtained with intravenously administered tri-(2-chlorethyl)amine hydrochloride in chronic myeloid and lymphatic leukaemias, Hodgkin's disease, and the reticuloses. Uracil mustard is a white crystalline substance that can be given orally with minimal toxic side-effects.…”

Synthesis and Antibacterial Activity of Chalcones and Pyrimidine‐2‐ones

“…Pyrimidines and their derivatives are considered to be important as drugs and agricultural chemicals. Some substituted pyrimidines and their derivatives have been reported to possess interesting biological activities such as hypnotic properties 8 , antifungal 9 , antitumour 10 , activities. Many pyrimidines are used as thyroid drugs.…”

The Use of Mechlorethamine, Cyclophosphamide, And Uracil Mustard in Neoplastic Disease: A Cooperative Study

“…Other objectives of the study were to secure information on any similarities in alkylating agents and on any differences that might exist between an enzymatically activated drug such as CY6,7 and a physiologic carrier such as UM. 3,8.G…”