5-Caffeoylquinic Acid Ameliorates Cognitive Decline and Reduces Aβ Deposition by Modulating Aβ Clearance Pathways in APP/PS2 Transgenic Mice

Ishida, Keiko; Misawa, Koichi; Nishimura, Hitomi; Hirata, Tomoya; Yamamoto, Masaki; Ota, Noriyasu

doi:10.3390/nu12020494

Cited by 37 publications

(23 citation statements)

References 54 publications

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“…A study published earlier this year has demonstrated chronic administration of 5-Caffeoylquinic Acid (5-CQA) to be effective in reducing Aβ deposition in the APP/PS2 AD mouse model, improving cognitive deficits and neuronal functions: 5-CQA normalised AQP4 perivascular mislocalisation and increased Aβ clearance along the glymphatic system [72], reiterating the importance of AQP4 in this clearance system.…”

Section: Discussionmentioning

confidence: 97%

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Silva

Ferreira

et al. 2021

Neurol. Res. Pract.

122

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Lacking conventional lymphatic system, the central nervous system requires alternative clearance systems, such as the glymphatic system, which promotes clearance of interstitial solutes. Aquaporin-4 water channels (AQP4) are an integral part of this system and related to neuropathologies, such as Alzheimer’s disease (AD). The clearance of Alzheimer’s associated proteins amyloid β and tau is diminished by glymphatic system impairment, due to lack of AQP4. Even though AQP4 mislocalisation (which affects its activity) is a phenotype of AD, it remains a controversial topic, as it is still unclear if it is a phenotype-promoting factor or a consequence of this pathology. This review provides important and updated knowledge about glymphatic system, AQP4 itself, and their link with Alzheimer’s disease. Finally, AQP4 as a therapeutic target is proposed to ameliorate Alzheimer’s Disease and other neuropathologies AQP4-related.

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Section: Discussionmentioning

confidence: 97%

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Silva

Ferreira

et al. 2021

Neurol. Res. Pract.

122

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“…The results indicated that chronic ingestion of CGA ameliorated cognitive deficits and prevented Aβ deposition and neuronal loss in these mice. CGA enhanced the gene expression of hippocampal low-density lipoprotein (LDL) receptor-related protein 1, which has a key role for Aβ clearance and cognitive function maintenance, and restored the perivascular localization of aquaporin 4, which facilitates Aβ clearance [ 43 ]. In a Aβ-induced cell model experiments, Shi et al [ 44 ] found that CGA increased the viability and decreased apoptosis of hippocampal neurons from newborn Sprague–Dawley rats treated with Aβ 25-35 .…”

Section: Alzheimer’s Disease (Ad)mentioning

confidence: 99%

Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases

Fukutomi¹,

Ohishi

Koyama

et al. 2021

Molecules

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Many observational and clinical studies have shown that consumption of diets rich in plant polyphenols have beneficial effects on various diseases such as cancer, obesity, diabetes, cardiovascular diseases, and neurodegenerative diseases (NDDs). Animal and cellular studies have indicated that these polyphenolic compounds contribute to such effects. The representative polyphenols are epigallocatechin-3-O-gallate in tea, chlorogenic acids in coffee, resveratrol in wine, and curcumin in curry. The results of human studies have suggested the beneficial effects of consumption of these foods on NDDs including Alzheimer’s and Parkinson’s diseases, and cellular animal experiments have provided molecular basis to indicate contribution of these representative polyphenols to these effects. This article provides updated information on the effects of these foods and their polyphenols on NDDs with discussions on mechanistic aspects of their actions mainly based on the findings derived from basic experiments.

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“…Firstly, we investigated in vitro and animal studies. 5-Caffeoylquinic acid may prevent cognitive impairment in mice with Alzheimer’s disease ( Ishida et al, 2020 ). Tangeretin may have therapeutic effects on rheumatoid arthritis in a rat model ( Li et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

A Deep Learning-Based Approach for Identifying the Medicinal Uses of Plant-Derived Natural Compounds

et al. 2020

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Medicinal plants and their extracts have been used as important sources for drug discovery. In particular, plant-derived natural compounds, including phytochemicals, antioxidants, vitamins, and minerals, are gaining attention as they promote health and prevent disease. Although several in vitro methods have been developed to confirm the biological activities of natural compounds, there is still considerable room to reduce time and cost. To overcome these limitations, several in silico methods have been proposed for conducting large-scale analysis, but they are still limited in terms of dealing with incomplete and heterogeneous natural compound data. Here, we propose a deep learning-based approach to identify the medicinal uses of natural compounds by exploiting massive and heterogeneous drug and natural compound data. The rationale behind this approach is that deep learning can effectively utilize heterogeneous features to alleviate incomplete information. Based on latent knowledge, molecular interactions, and chemical property features, we generated 686 dimensional features for 4,507 natural compounds and 2,882 approved and investigational drugs. The deep learning model was trained using the generated features and verified drug indication information. When the features of natural compounds were applied as input to the trained model, potential efficacies were successfully predicted with high accuracy, sensitivity, and specificity.

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5-Caffeoylquinic Acid Ameliorates Cognitive Decline and Reduces Aβ Deposition by Modulating Aβ Clearance Pathways in APP/PS2 Transgenic Mice

Cited by 37 publications

References 54 publications

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Glymphatic system, AQP4, and their implications in Alzheimer’s disease

Beneficial Effects of Epigallocatechin-3-O-Gallate, Chlorogenic Acid, Resveratrol, and Curcumin on Neurodegenerative Diseases

A Deep Learning-Based Approach for Identifying the Medicinal Uses of Plant-Derived Natural Compounds

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