5-Fluorouracil and Its Prodrug Capecitabine: Occurrence, Fate and Effects in the Environment

Ljoncheva, Milka; Kosjek, Tina; Isidori, Marina; Heath, Ester

doi:10.1007/978-3-030-21048-9_14

Cited by 4 publications

(1 citation statement)

References 67 publications

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“…Considering that the literature data related to DOX electrochemical determination mechanisms [21,23,32] corroborated the above-presented results, two-electron based DOX electrooxidation and electroreduction involving Fe species and ferrocene redox couples are proposed for both pHs of 12 and 3, with very fast kinetics at pH 3. Also, the two-electron oxidation and reduction processes are proposed for CPP and its oxidized form in accordance with the literature data [42] and for CPB oxidation and reduction, also as reported in the literature [47][48][49]. The lack of anodic and cathodic peak current intensification with increasing CPP and CPB concentrations at pH 3 should be explained by much lower kinetics or the lack of their oxidation and reduction processes in comparison with DOX ones.…”

Section: Cyclic Voltammetry (Cv)supporting

confidence: 87%

Ferrocene-Containing Gallic Acid-Derivative Modified Carbon-Nanotube Electrodes for the Fast Simultaneous and Selective Determination of Cytostatics from Aqueous Solutions

Motoc (m. Ilies),

Andelescu,

Visan

et al. 2024

Chemosensors

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In this work, a ferrocene-containing gallic acid-derivative modified carbon-nanotube paste electrode (Gal-Fc-CNT), obtained through simple mechanical mixing, was studied for the fast simultaneous voltammetric determination of doxorubicin (DOX), capecitabine (CPB), and cyclophosphamide (CPP) as cytostatic indices based on their cumulative signals and the selective determination of DOX. The individual and simultaneous electrochemical behavior of DOX, CPB, and CPP, studied through cyclic voltammetry (CV) on the Gal-Fc-CNT paste electrode at various pHs and potential ranges, allowed for the development of a simple simultaneous determination method as a cytostatic index at a pH of 12 using square-wave voltammetry, which allowed for a better performance than reported electrodes for each individual cytostatic. A faster and selective detection of DOX, with a limit of detection of 75 ng·L−1, was achieved using square-wave voltammetry at a pH of 3. The good results obtained for the real tap water assessment indicated the applicability of the Gal-Fc-CNT paste electrode for practical applications (water samples).

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