5‐fluorouracil‐induced erythema and transepidermal water loss associated with complete actinic keratosis resolution

Maarouf, Melody; Kromenacker, Bryan; Brucks, Eric; Hendricks, Aleksi J.; Shi, Vivian Y.

doi:10.1111/dth.12890

Cited by 1 publication

(5 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also observed an increase in TEWL after the first PDT session, although this parameter tends to decrease non‐significantly 1 week and 1 month after PDT administration. The increase in TEWL has been reported in other therapies that also produce inflammation on the affected skin, related to the complete resolution of AKs 19 . However, in their study, Faurschou et al observed that TEWL was not significantly different in the control group or in the PDT group, 7 suggesting that TEWL is independent of the inflammation produced by PDT.…”

Section: Discussionmentioning

confidence: 73%

“…The increase in TEWL has been reported in other therapies that also produce inflammation on the affected skin, related to the complete resolution of AKs. 19 However, in their study, Faurschou et al observed that TEWL was not significantly different in the control group or in the PDT group, 7 suggesting that TEWL is independent of the inflammation produced by PDT. A non‐significant decreasing trend in TEWL has been reported in patients with psoriasis after phototherapy.…”

Section: Discussionmentioning

confidence: 86%

“…We have not found studies analyzing this parameter in patients with AKs treated with PDT, but other studies in psoriatic patients treated with phototherapy suggest that this parameter is useful to optimize the dose of therapy, 14 so this could also be useful for optimizing doses in PDT. This increase would be explained by the inflammatory response that can appear after a PDT session, and has been observed when studying skin homeostasis on treatments that induce inflammation 13,19,20,21 …”

Section: Discussionmentioning

confidence: 92%

“…This increase would be explained by the inflammatory response that can appear after a PDT session, and has been observed when studying skin homeostasis on treatments that induce inflammation. 13,19,20,21 At the moment, no other study has analyzed differences between PDT modalities (occlusive vs. mixed) and their impact on skin homeostasis. The increase in temperature in affected skin after the first PDT session is greater in the occlusive modality than in the mixed modal-ity.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

The impact of photodynamic therapy on skin homeostasis in patients with actinic keratosis: A prospective observational study

Soto‐Moreno,

Montero‐Vilchez,

Diaz‐Calvillo

et al. 2023

Skin Research and Technology

View full text Add to dashboard Cite

BackgroundPhotodynamic therapy (PDT) is an effective treatment for actinic keratosis (AKs), but there is little information on how PDT affects skin barrier function. The objectives of this study are: To compare skin barrier function between skin with AKs and healthy skin and to evaluate the impact of PDT on skin homeostasis in patients with AKs.MethodsA prospective observational study was conducted in patients with AKs to evaluate epidermal barrier function and skin homeostasis before and 1 ek after receiving PDT.ResultsA total of 21 subjects were included in the study, male/female ratio was 17:4, mean age was 75.86 years. The number of AKS observed before starting treatment was reduced with respect to those diagnosed 1 month after starting PDT (14.83 vs. 1.91, p < 0.0001). Application of PDT for treating AKs modifies epidermal barrier function. Immediately after the first session temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH) and total antioxidant capacity (TAC) increased while pH decreased on lesional skin. After 1‐month follow‐up, the only remained change was the increased in SCH. Higher increases in temperature were observed when using occlusive PDT compared to mixed modality. 5‐ALA and M‐ALA seem to have a similar impact on skin barrier.ConclusionsPDT can improve skin barrier function in patients with AKs. Skin homeostasis parameters can be used to assess efficacy and optimize dosing.

show abstract

Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 86%