5 Glioblastoma Multiforme and Anaplastic Astrocytoma

Burger, Peter C.; Vogel, F. S.; Green, S. B.; Strike, Thomas A.

doi:10.1097/00005072-198305000-00015

Cited by 9 publications

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“…The presence of either necrosis or mitosis in the tumor specimen was associated significantly with poorer outcome. This finding is consistent with reports on the importance of necrosis or mitosis as prognostic criteria in adult malignant glioma [11,12,19] and in childhood brain stem glioma [20]. This class of neoplasms displays heterogeneity in other histologic characteristics [10] which were not studied.…”

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confidence: 92%

The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: Results of a randomized trial

et al. 1989

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Fifty-eight patients with high-grade astrocytoma were treated by members of the Childrens Cancer Study Group in a prospective randomized trial designed to study the effectiveness of chemotherapy as an adjuvant to standard surgical treatment and radiotherapy. Following surgical therapy, patients were assigned randomly to radiotherapy with or without chemotherapy consisting of chloroethyl-cyclohexyl nitrosourea, vincristine, and prednisone. Treatment with chemotherapy prolonged survival and event-free survival. Five-year event-free survival was 46% for patients in the radiotherapy and chemotherapy group, and 18% for patients in the radiotherapy-alone group. Five-year survival was similarly improved. The differences in outcome due to treatment were statistically significant after correcting for imbalances in important prognostic factors (event-free survival, p = 0.026; survival, p = 0.067). The presence of mitoses or necrosis in the tumor specimen was associated with poorer outcome. Patients whose initial surgery was limited to biopsy, and patients with basal ganglia lesions, also had significantly worse outcome. Chemotherapy administered at the time of recurrence in a small number of patients did not produce any long-term survivors. This study is to our knowledge the only randomized trial to investigate effectiveness of chemotherapy in the treatment of high-grade astrocytoma in children.

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confidence: 92%

The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: Results of a randomized trial

et al. 1989

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“…Patients were eligible for this trial if they met the following criteria: 1) age 18 or older; 2) histologic grade III or IV glioma (Daumas-Duport/Burger Classification [23,24]); 3) Karnofsky score greater or equal to 60; 4) recurrent tumor of sufficient size and location to warrant surgery; 5) exhausted conventional therapeutic alternatives; and, 6) adequate hematologic status to allow leukapheresis.…”

Section: Patient Selection and Protocol Designmentioning

confidence: 99%

Therapy of recurrent high grade gliomas with surgery, and autologous mitogen activated IL-2 stimulated killer (MAK) Lymphocytes: I. Enhancement of MAK lytic activity and cytokine production by PHA and clinical use of PHA

Jeffes

Beamer²,

Jacques³

et al. 1993

J Neuro-Oncol

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“…Astrocytomas of the cerebellum are one of the two most common brain tumors in childhood, and have a slow biological progression and relatively favorable clinical outcome. With increasing age, the more malignant astrocytic tumors become more prevalent, consequently for these tumors there is a progressively worse survival rate with increasing age (Burger et al, 1985;Burger and Green, 1987). Astrocytomas of the brainstem (brainstem gliomas) tend to occur at younger ages.…”

Section: Molecular and Chemical Neuropathologymentioning

confidence: 99%

“…The histological border at which an anaplastic astrocytoma becomes a glioblastoma multiforme has not been precisely defined. In more recent years the presence of necrosis in an anaplastic astrocytoma has been found to be a strong correlate of rapid progression, so necrosis is being used more frequently as an absolute diagnostic criterion of GBM (Nelson et al, 1983;Burger et al, 1985). However, it is important to remember that the degrees of histological anaplasia in gliomas exist along a spectrum, and the combinations and range of anaplastic features over which one diagnostic entity exists is neither precisely defined nor entirely objectively determined.…”

Section: Glioblastoma Multiformementioning

confidence: 99%

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An overview of principles for classifying brain tumors

Yates

1992

Molecular and Chemical Neuropathology

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The purpose of this review is to clarify for the nonneuropathologist some of the confusing issues concerning the classification of brain tumors. Following a short discussion of the commonly used methods to diagnose brain tumors clinically (frozen section, light and electron microscopy, immunohistochemistry), the general principles of classifying neural tumors are presented. Grading of tumors on the basis of histological anaplasia, and the concept that tumor cells can be related to specific cytological stages of normal cellular development (cytogenetic classification) are presented. The World Health Organization system of classifying neural tumors is an attempt to develop a standardized classification scheme with as few interpretative controversies as possible, but it has required revision as new information has been gained. The major clinical and biological features of the commonest tumor groups are then discussed. It is unlikely that improvements in the classification of brain tumors will be based solely on histological information. Definitions of tumor entities that will provide more accurate prognoses and bases for effective therapy will require considerably more information at the molecular level than is currently available.

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5 Glioblastoma Multiforme and Anaplastic Astrocytoma

Cited by 9 publications

References 0 publications

The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: Results of a randomized trial

The effectiveness of chemotherapy for treatment of high grade astrocytoma in children: Results of a randomized trial

Therapy of recurrent high grade gliomas with surgery, and autologous mitogen activated IL-2 stimulated killer (MAK) Lymphocytes: I. Enhancement of MAK lytic activity and cytokine production by PHA and clinical use of PHA

An overview of principles for classifying brain tumors

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