5-HT1A-mediated lower lip retraction: Effects of 5-HT1A agonists and antagonists

Serotonin-1A antagonists attenuate the effects of nicotine withdrawal on the auditory startle response

“…has been shown to have 5-HT-1A partial agonist properties in some assays (Hjorth and Sharp, 1990;Rydelek-Fitzgerald et al, 1990), and has also been shown to have alpha-1 antagonist properties in vivo (Claustre et al, 1991). However, displays good efficacy at blocking the effects of 5-HT-1A agonists at postsynaptic receptors (Moore et al, 1993). LY206130 is a derivative of pindolol that has a .20-fold selectivity for 5-HT-1A receptors vs. beta adrenergic receptors and is a potent 5-HT-1A antagonist in vivo with no apparent partial agonist activity Fuller et al, 1996;Wong et al, 1994).…”

A Search for New 5-HT1A/5-HT2A Receptor Ligands. In Vitro and in vivo Studies of 1-[ω-(4-Aryl-1-piperazinyl)alkyl]indolin-2(1H)-ones

“…NAN-190 or MM-77, in the in vivo tests used. However, the observed in vivo activity of those agents was slightly weaker than that of NAN-190 and MM-77 [13,14,15] . Compounds 5 (2.5-10 mg/kg) and 7 (5-20 mg/kg) inhibited in a dose dependent manner the (±)DOI-induced head twitch response in mice (Table 5).…”

Pharmacological profile of LY301317, a potent and selective 5-HT1A agonist

“…In rats, 5-HT 1A receptor agonists induce a characteristic behavioral syndrome that includes a flat body posture (FBP), reciprocal forepaw treading, straub tail and lower lip retraction (LLR) [Smith and Peroutka, 1986;Berendsen et al, 1989]. Of these behaviors, LLR and FBP are relatively easy to quantify and are sensitive to the effects of 5-HT 1A receptor agonists and antagonists [Berendsen et al, 1989;Moore et al, 1993]. LY301317 induced LLR and FBP at 3 mg/kg po and at 0.06 mg/kg sc, yielding a po:sc ratio in this test system of 50:1.…”