5-HT1B receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and running

Fish, Eric W.; McKenzie-Quirk, Sara D.; Bannai, Makoto; Miczek, Klaus A.

doi:10.1007/s00213-007-1017-3

Cited by 31 publications

(40 citation statements)

References 77 publications

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“…The effects of androgens on sexual motivation in rodents have been demonstrated previously using partner preference for a receptive female (Feinberg et al, 1997; Agmo, 2003; Wesson and McGinnis, 2006), searching in a multi-level chamber (Roselli et al, 2003), or operant responding for the opportunity to mate (Everitt and Stacey, 1987). The design of the present study was based on modifications of previous studies using FI- (Fish et al, 2008) and 2 nd -order FR-schedules to evaluate operant responding for social behavior. Fish et al (2008) measured alcohol-induced aggressive motivation by responses on an FI-10 schedule in the home cage.…”

Section: Discussionmentioning

confidence: 99%

“…The design of the present study was based on modifications of previous studies using FI- (Fish et al, 2008) and 2 nd -order FR-schedules to evaluate operant responding for social behavior. Fish et al (2008) measured alcohol-induced aggressive motivation by responses on an FI-10 schedule in the home cage. We recently applied this model to study AAS-induced aggressive motivation (Wood et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

“…The first experiment used a 10-minute fixed-interval (FI) schedule of reinforcement (FI-10), according to methods of Wood et al (2013) as modified from Scott et al (1994) and Fish et al (2008). A second experiment provided access to the female on a 2 nd -order schedule of reinforcement (2 nd -order FR), using modifications of Everitt et al (1987).…”

Section: Methodsmentioning

confidence: 99%

“…The reward (initially a Froot Loop, later an estrous female rat) was present behind a perforated Plexiglas screen adjacent to the nose-poke, permitting transmission of visual, auditory and olfactory stimuli. Responses on the nose-poke were recorded and reinforced on a FI schedule, as in previous studies of aggressive motivation in mice (Fish et al, 2008) and rats (Wood et al, 2013). The initial FI was 30 sec, subsequently increased to 1 min, and by 1-min increments thereafter until a 10 min FI was reached.…”

Section: Methodsmentioning

confidence: 99%

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Anabolic–androgenic steroids and appetitive sexual behavior in male rats

Kim

Wood

2014

Hormones and Behavior

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Anabolic-androgenic steroids (AAS) increase libido and sexual behavior, but the underlying behavioral mechanisms are unclear. One way AAS may enhance expression of sexual behavior is by increasing the willingness to work for sex. In the present study, sexually-experienced male rats received daily injections of testosterone at supraphysiologic doses (7.5 mg/kg in water with 13% cyclodextrin) or vehicle and were tested for appetitive sexual behavior measured by operant responding for access to an estrous female. Initially, rats were trained in their home cage to respond on a nose-poke under a 10-min fixed-interval schedule for food reward. Once rats achieved stable response rates, the food was replaced by a female, followed by mating for 10 min. There was no effect of testosterone on operant responding for food (28.1±4.4 responses/10 min for testosterone, 30.6±4.3 for vehicle) or sex (35.0±4.0 responses/10 min for testosterone, 37.3±5.2 for vehicle). However, rats made significantly more responses for sex than for food (p<0.05), and responses for food and sex were positively correlated among individuals (R2=0.6). Additional groups of rats were trained to respond on a lever for the female under a 2nd-order schedule of reinforcement, where 5 responses opened a door to show the female for 5 seconds. After 15 door openings, the male gained access to the female. There was no effect of testosterone on time to complete 75 responses: 38.4±7.8 minutes for vehicle controls vs 43.3±6.6 minutes for testosterone-treated rats (p>0.05). These findings suggest that chronic high-dose testosterone does not enhance appetitive drive for sexual behavior.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Anabolic–androgenic steroids and appetitive sexual behavior in male rats

Kim

Wood

2014

Hormones and Behavior

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“…In some instances, it is used as sedative before surgery in part because it causes amnesia [2]. People administered with this drug do not remember the surgery and circumstances surrounding it [3]. It is referred to as a date rape drug because when the drug is given to a person in a club, it can facilitate a sexual assault.…”

Section: Introductionmentioning

confidence: 99%

Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats

Oladele¹

2017

AJLM

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Rohypnol and alcohol abuse is often reported among young people. Rohypnol is often abused voluntarily to erase memory of indulgence. It is also used in perpetuating crime such as in rape cases when the perpetrator administers certain doses of rohypnol to make the victim lose the memory of such event. Interestingly, young people often abuse alcohol and rohypnol. While the former is often used as a social drug, the latter is combined in certain instances to erase or reduce the memory of such. A number of literatures exist on the effects of alcohol on heath, brain and mind; but not a good number of investigations have considered the effects of rohypnol on hippocampal structure as well as the nature of its effects when combined with alcohol. This particular investigation is aimed at modelling rohypnol and alcohol abuse and resultant effects on hippocampal histoarchitecture and biochemicals in Wistar rats. Forty eight [n=48] adult male Wistar rats were divided into six groups, A-F. Group A served as the control Group B received the low dose of flunitrazepam; Group C received the high dose of flunitrazepam; Group D received the low dose of alcohol; Group E received the high dose of alcohol; Group F received the low dose of flunitrazepam and alcohol. Experiment lasted 21 days and animals were sacrificed by cervical dislocation. Results showed that the two substances did not produce extensive structural disruption of the hippocampus. However, specific regions of the hippocampus showed morphological aberrations, resulting in mild heterogeneity. Also, the enzyme chemistry of the hippocampus cytochrome C oxidase and G6PDH enzymes was altered.

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Translational Clinical Neuroscience Perspectives on the Cognitive and Neurobiological Mechanisms Underlying Alcohol-Related Aggression

Beck

Heinz

2013

Neuroscience of Aggression

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Alcohol-related violence, a longstanding, serious, and pervasive social problem, has provided researchers from diverse disciplines with a model to study individual differences in aggressive and violent behavior. Of course, not all alcohol consumers will become aggressive after drinking and similarly, not all individuals with alcohol use disorders will exhibit such untoward behavior. Rather, the relationship is best conceptualized as complex and indirect and is influenced by a constellation of social, cognitive, and biological factors that differ greatly from one person to the next. Animal experiments and human studies have elucidated how these mechanisms and processes explain (i.e., mediate) the relation between acute and chronic alcohol consumption and aggressive behavior. Further, the rich body of literature on alcohol-related aggression has allowed for identification of several potential high-yield targets for clinical intervention, e.g., cognitive training for executive dysfunction; psychopharmacology targeting affect and threat perception, which may also generalize to other psychiatric conditions characterized by aggressive behavior. Here we aim to integrate pertinent findings, derived from different methodological approaches and theoretical models, which explain heterogeneity in aggressive responses to alcohol. A translational platform is provided, highlighting common factors linking alcohol and aggression that warrant further, interdisciplinary study in order to reduce the devastating social impact of this phenomenon.

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5-HT1B receptor inhibition of alcohol-heightened aggression in mice: comparison to drinking and running

Cited by 31 publications

References 77 publications

Anabolic–androgenic steroids and appetitive sexual behavior in male rats

Anabolic–androgenic steroids and appetitive sexual behavior in male rats

Modelling Rohypnol [Flunitrazepam] and Alcohol Abuse and Resultant Effects on Hippocampal Histoarchitecture and Biochemicals in Wistar Rats

Translational Clinical Neuroscience Perspectives on the Cognitive and Neurobiological Mechanisms Underlying Alcohol-Related Aggression

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