5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats

Impérato, Assunta; Angelucci, L.

doi:10.1016/0304-3940(89)90533-8

Cited by 206 publications

(136 citation statements)

References 8 publications

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“…Intra-NA administration of the 5-HT3 antagonist ondansetron reduced the DA effects elicited by morphine (De Deurwaerdere et al, 2005). Interestingly, intra-VTA 5-HT3 antagonism with ICS 205-930 also attenuates the morphine-induced increases in NA DA (Imperato and Angelucci, 1989) and the morphine-induced increase in VTA DA (Campbell et al, 1996). Likewise, pretreatment with 5-HT3 antagonists (MDL 72222, ondansetron or ICS 205-930) attenuated morphine-induced increases in behavioral activity (Pei et al, 1993) and morphine-place preference (Carboni et al, 1988;Higgins et al, 1992).…”

Section: Mesolimbic Pathwaymentioning

confidence: 93%

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

Alex

Pehek

2007

Pharmacology & Therapeutics

536

311

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The neurotransmitter dopamine (DA) has a long association with normal functions such as motor control, cognition, and reward, as well as a number of syndromes including drug abuse, schizophrenia, and Parkinson's disease. Studies show that serotonin (5-HT) acts through several 5-HT receptors in the brain to modulate DA neurons in all three major dopaminergic pathways. There are at least 14 5-HT receptor subtypes, many of which have been shown to play some role in mediating 5-HT/DA interactions. Several subtypes, including the 5-HT1A, 5-HT1B, 5-HT2A, 5-HT3 and 5-HT4 receptors, act to facilitate DA release, while the 5-HT2C receptor mediates an inhibitory effect of 5-HT on DA release. Most 5-HT receptor subtypes only modulate DA release when 5-HT and/or DA neurons are stimulated, but the 5-HT2C receptor, characterized by high levels of constitutive activity, inhibits tonic as well as evoked DA release. This review summarizes the anatomical evidence for the presence of each 5-HT receptor subtype in dopaminergic regions of the brain and the neuropharmacological evidence demonstrating regulation of each DA pathway. The relevance of 5-HT receptor modulation of DA systems to the development of therapeutics used to treat schizophrenia, depression, and drug abuse is discussed. Lastly, areas are highlighted in which future research would be maximally beneficial to the treatment of these disorders.

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Section: Mesolimbic Pathwaymentioning

confidence: 93%

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

Alex

Pehek

2007

Pharmacology & Therapeutics

536

311

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“…The dense innervation of both the cell body and terminal regions of the mesoaccumbens dopamine system by the DRN is consistent with the capacity of intra-DRN administration of DPAT to potentiate the effect of acute cocaine on accumbens dopamine transmission. Previous reports on the electrophysiological and neurochemical effects of reducing serotonin tone in the ventral tegmental area and accumbens, respectively, indicate mixed effects depending in part on the serotonin receptor subtype examined and the basal activity of the dopamine cells (Imperato and Angelucci, 1989;Chen and Reith, 1994;Di Mascio and Esposito, 1997;Lejeune and Millan, 1998;Parsons et al, 1999). A contributing factor to the enhanced dopamine release may be the rise in extracellular glutamate produced by the combination of intra-DRN DPAT and acute cocaine since, in some studies, glutamate receptor stimulation enhances dopamine release (Meltzer et al, 1997;Whitton, 1997 for reviews).…”

Section: Serotonin Projections From the Drn Regulate The Acute Effectmentioning

confidence: 94%

Dissociable Roles for the Dorsal and Median Raphé in the Facilitatory Effect of 5-HT1A Receptor Stimulation upon Cocaine-Induced Locomotion and Sensitization

Szumlinski

Frys

Kalivas

2004

Neuropsychopharmacol

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A distinct role for serotonin transmission from the dorsal and median raphé nuclei (DRN and MRN, respectively) was identified in regulating the behavioral and neurochemical effects of acute and repeated cocaine administration. Serotonin 1A (5-hydroxytryptophan (5-HT)1A) receptors were stimulated by intraraphé microinjection of 8-hydroxy-2-(di-n-propylamino)tetralin (DPAT; 5 or 10 mg) and behavior, as well as extracellular neurotransmitter content in the nucleus accumbens was measured. Pretreatment of the DRN with DPAT caused a sensitization-like potentiation of acute cocaine-induced motor activity and an elevation in extracellular dopamine and glutamate. In contrast, DPAT microinjection into the MRN did not alter acute cocaine-induced motor activity or extracellular levels of dopamine or glutamate. Acutely, DPAT microinjection into either raphé nucleus reduced the basal and acute cocaine-stimulated levels of extracellular serotonin. Pretreatment with DPAT before systemic cocaine administration was continued for 5 days, and 3 weeks after the last injection, all rats were administered a cocaine challenge injection. The sensitized behavioral and neurochemical response produced by repeated cocaine in control subjects was unaffected by the intra-DRN administration of DPAT. However, in animals administered DPAT into the MRN, both the sensitized motor response and the increase in glutamate were augmented, while the sensitized serotonin response was blocked, without altering dopamine sensitization. These data show a differential role for 5-HT1A receptors in the DRN and MRN in the acute and sensitized effects of cocaine. While the DRN is involved in the acute effects of cocaine, neuroadaptations in the MRN may regulate the long-term consequences of repeated cocaine exposure.

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“…We measured alcohol-induced locomotor activity as most drugs of abuse (including alcohol) cause locomotor stimulation, an effect mediated, at least in part, by their ability to enhance the extracellular concentration of accumbal dopamine (Engel et al, 1988;Imperato and DiChiara, 1986;Wise and Bozarth, 1987). It should however be emphasized that other neurotransmitters mediate alcohol-induced locomotor stimulation (Engel et al, 1992).…”

Section: Locomotor Activity Experimentsmentioning

confidence: 99%

The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice

Jerlhag

Landgren

Egecioglu

et al. 2011

Alcohol

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5-HT3 receptors control dopamine release in the nucleus accumbens of freely moving rats

Cited by 206 publications

References 8 publications

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission

Dissociable Roles for the Dorsal and Median Raphé in the Facilitatory Effect of 5-HT1A Receptor Stimulation upon Cocaine-Induced Locomotion and Sensitization

The alcohol-induced locomotor stimulation and accumbal dopamine release is suppressed in ghrelin knockout mice

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