5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons

Meuser, Thomas; Pietruck, Christian; Gabriel, Anja; Xie, Guoxi; Lim, Kye-Taek; Palmer, Pamela Pierce

doi:10.1016/s0024-3205(02)02011-8

Cited by 79 publications

(68 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The reasons for these differences are not clear, but they might be due to the age of the animals or sites of DRG tested. The present results were consistent with previous in situ hybridization and immunohistochemical data showing that 5-HT 1B (Doucet et al 1996), 5-HT 2A (Tokunaga et al 1998), 5-HT 3 (Tecott et al 1993;Kia et al J Physiol 576.3 1995) and 5-HT 7 (Meuser et al 2002;Doly et al 2005) are present in rat DRG.…”

Section: Discussionsupporting

confidence: 93%

“…In the present study, since RT-PCR analysis revealed the absence of 5-HT 1A receptor mRNA, it is likely that the potentiating effect of 8OH-DPAT on capsaicin-induced [Ca 2+ ] i increases was mediated by 5-HT 7 receptors. In the rat, production of c-fos in the spinal dorsal horn is increased when a 5-HT 7 receptor agonist is administered (Meuser et al 2002). The present data suggest that 5-HT 7 receptors in part play a role in hyperalgesia induced by 5-HT.…”

Section: Discussionsupporting

confidence: 49%

See 1 more Smart Citation

Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5‐HT receptors in rat primary sensory neurons

Ohta

Ikemi

Murakami

et al. 2006

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 49%

Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5‐HT receptors in rat primary sensory neurons

Ohta

Ikemi

Murakami

et al. 2006

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…This putative sensory modulation role is consistent with the presence of 5-HT receptors in the dorsal horn of the lumbosacral spinal cord (Liu et al, 2002). Furthermore, numerous findings associate 5-HT with sensory input modulation (Machacek et al, 2001;Meuser et al, 2002;Miquel et al, 2002;Shay and Hochman, 2002;Bosco et al, 2003;Hains et al, 2003). In intact cats, monoamine release selectively increases the excitability of some reflex circuits but decreases the excitability of others, e.g., potentiating transmission from group I spindle fibers and tendon organs (Edgley et al, 1988;Bras et al, 1990) while depressing transmission from nociceptors and group II fibers (Headley et al, 1978; Figure 5.…”

Section: Discussionsupporting

confidence: 79%

Spinal Cord-Transected Mice Learn to Step in Response to Quipazine Treatment and Robotic Training

Fong¹,

Cai²,

Otoshi³

et al. 2005

J. Neurosci.

131

126

View full text Add to dashboard Cite

In the present study, concurrent treatment with robotic step training and a serotonin agonist, quipazine, generated significant recovery of locomotor function in complete spinal cord-transected mice (T7-T9) that otherwise could not step. The extent of recovery achieved when these treatments were combined exceeded that obtained when either treatment was applied independently. We quantitatively analyzed the stepping characteristics of spinal mice after alternatively administering no training, manual training, robotic training, quipazine treatment, or a combination of robotic training with quipazine treatment, to examine the mechanisms by which training and quipazine treatment promote functional recovery. Using fast Fourier transform and principal components analysis, significant improvements in the step rhythm, step shape consistency, and number of weight-bearing steps were observed in robotically trained compared with manually trained or nontrained mice. In contrast, manual training had no effect on stepping performance, yielding no improvement compared with nontrained mice. Daily bolus quipazine treatment acutely improved the step shape consistency and number of steps executed by both robotically trained and nontrained mice, but these improvements did not persist after quipazine was withdrawn. At the dosage used (0.5 mg/kg body weight), quipazine appeared to facilitate, rather than directly generate, stepping, by enabling the spinal cord neural circuitry to process specific patterns of sensory information associated with weight-bearing stepping. Via this mechanism, quipazine treatment enhanced kinematically appropriate robotic training. When administered intermittently during an extended period of robotic training, quipazine revealed training-induced stepping improvements that were masked in the absence of the pharmacological treatment.

show abstract

“…A role in upper intestinal smooth muscle relaxation [41,42] , activation of afferent neurons [43] as well as high expression in the stomach and ileum [44] has been revealed previously, and we found high expression in duodenal samples. Our results also indicate significant differences in expression level between patients with FD and controls.…”

Section: Discussionsupporting

confidence: 76%

Duodenal epithelial transport in functional dyspepsia: Role of serotonin

Witte

D’Amato

Poulsen

et al. 2013

WJGP

View full text Add to dashboard Cite

AB performed the research with the exception of PCR experiments and the histological staining process and analysed as well as summarized the data; Knuhtsen S performed the endoscopic examinations and assisted in characterizing patients and controls; Bindslev N and Hansen MB provided technical guidance and facilities for biopsy sampling and Ussing experiments; D'Amato M and Laurent A performed the expression studies; Poulsen SS contributed with histological evaluation and guidance in the field; Schmidt PT participated in the data analysis and held overall responsibility for ethical and economic aspects; all authors participated in the revision of the manuscript and approved the final version. The following genes were highly expressed: 5-HT receptor HTR 3E, HTR4 , HTR7 , SERT gene (SLC6A4 ) and TPH1 . Differences in expression levels were observed for HTR3E (higher expression in FD, P = 0.008), HTR7 (lower expression in FD, P = 0.027), SLC6A4 (higher expression in FD, P = 0.033) and TPH1 (lower expression in FD, P = 0.031). CONCLUSION:Duodenal ion transport in response to exogenous 5-HT is abnormal in FD patients and associated with high expression of the HTR3E receptor and the serotonin transporter.© 2013 Baishideng. All rights reserved.

show abstract

5-HT7 receptors are involved in mediating 5-HT-induced activation of rat primary afferent neurons

Cited by 79 publications

References 25 publications

Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5‐HT receptors in rat primary sensory neurons

Potentiation of transient receptor potential V1 functions by the activation of metabotropic 5‐HT receptors in rat primary sensory neurons

Spinal Cord-Transected Mice Learn to Step in Response to Quipazine Treatment and Robotic Training

Duodenal epithelial transport in functional dyspepsia: Role of serotonin

Contact Info

Product

Resources

About