5-Hydroxy-7-chlortetracycline

Mitscher, L. A.; Martin, Joerg; Miller, Pamela; Shu, Panyin; Bohonos, N.

doi:10.1021/ja00967a033

Cited by 15 publications

(6 citation statements)

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“…The tetracyclines 64, 65 [86] are broad-spectrum antibiotics and were produced by different Streptomyces species. They have activity against both Gram-positive and Gram-negative bacteria.…”

Section: Importance Of Bacteria For the Development Of Drug Researchmentioning

confidence: 99%

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A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Ueda¹,

Hashimoto²,

Yamamura³

et al. 2011

J Antibiot

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“…The tetracyclines 64, 65 [86] are broad-spectrum antibiotics and were produced by different Streptomyces species. They have activity against both Gram-positive and Gram-negative bacteria.…”

Section: Importance Of Bacteria For the Development Of Drug Researchmentioning

confidence: 99%

“…In a first step, the naphthalene carboxylic acid 71 could be combined with cysteine (86) followed by cyclization and reduction to give karamomycin A (73). On dehydrogenation, the latter would yield karamomycin B (75).…”

Section: Hypothetic Biosynthetic Pathway Of Karamomycinsmentioning

confidence: 99%

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Ueda¹,

Hashimoto²,

Yamamura³

et al. 2011

J Antibiot

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“…After considerable labor, this was found to be the case. [28][29][30] Isolation of the active product was exceptionally difficult because it was not stable at pH levels where it separated from contaminants by column partition chromatography. Ultimately this was solved by dripping the column eluants into buffer solutions to adjust the pH to a safe range rapidly.…”

Section: Directed Biosynthesismentioning

confidence: 99%

“…Making these molecules also required the development of novel chemistry leading to a very substantial improvement in antimicrobial potency that included otherwise fluoroquinolone-resistant organisms. The best of these agents, ABT-719 (30), has been evaluated in the clinic but has not been marketed, apparently due to unattractive side-effects. 95 Additional explorations included different annealing of the benzene ring, its attachment by a single C-C bond, and the like.…”

Section: Antimicrobial Agents From Higher Plantsmentioning

confidence: 99%

Coevolution: Mankind and Microbes

Mitscher

2008

J. Nat. Prod.

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In just 70 short years mankind has progressed from euphoria to despair over the effectiveness of antibiotics to protect and to cure mankind from morbidity and mortality from infectious diseases. Resistance due to evolutionary factors was observed shortly after antibiotics came into use and is now not only widespread but appears to be inevitable. This review is a rather personalized account of the various attempts to deal with this problem over time.

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“…Feeding experiments to elucidate the biosynthesis of the karamomycins have not been performed so far, so that the following considerations are highly speculative. In a first step, the naphthalene carboxylic acid 71 could be combined with cysteine (86) followed by cyclization and reduction to give karamomycin A (73). On dehydrogenation, the latter would yield karamomycin B (75).…”

Section: Hypothetic Biosynthetic Pathway Of Karamomycinsmentioning

confidence: 99%

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

Mahmoud¹

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sources of bioactive constituents, as most medicinal plants (~97%) have been totally investigated. So, many other natural sources were being taken into consideration, especially those located in marine habitats e.g. soft corals, sponges, jellyfishes, algae, and microorganisms. Microorganisms are living symbiotically or located in sediments and represent a huge source of diverse bioactive secondary metabolites. Such diversity increases the possibility of structural novelty as well as bioactivity.Penicillin (1), one of the first antibiotics from microorganisms, was discovered in 1928 by Fleming, showing a bactericidal activity against the Staphylococcus sp.For this great discovery, Fleming, Chian and Florey were honoured with the Nobel Prize in 1945 [7] . Since the discovery of penicillin (1) and mycophenolic acid (2) before [8] , microorganisms, especially bacteria, played an essential role in the production of antibiotics and other drugs for the treatment of current diseases [9, 10] . 7The systematic investigations of marine environment as sources of novel biologically active agents began intensively in the mid 1970s. Among the phyla in the oceans, bacteria, fungi, algae, sponges, coelenterates, sea hares, bryozoans, tunicates and nudibranchs have been studied [28,29] . There is, however, a continual increasing of the reported new compounds from marine sources since 1965 (Figure 1). Sponges followed by coelenterates were the most studied marine organisms. Since that time, 13Didemnin B (13), a depsipeptide, was isolated from the Caribbean tunicateTrididemnum solidum [34] , inhibiting the synthesis of RNA, DNA and proteins in various cancer cell lines. It shows anti-viral and immunosuppressive activities as well as being an effective agent in treatment of leukaemia and melanoma. However, due to its toxicity, it was withdrawn from phase II clinical trials [35,36] .Thiocoraline ( 14), a novel depsipeptide was isolated (1997) from the mycelial extract of the bacterium Micromonospora marina, associated with a marine soft coral in the Indian Ocean. Thiocoraline (14) showed potent cytotoxic activity at a nanomolar concentration against several tumor cell lines. It inhibits DNA polymerase [37,38] . It is currently in preclinical phase by PharmaMar.

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5-Hydroxy-7-chlortetracycline

Cited by 15 publications

References 0 publications

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

A new 16-membered tetraene macrolide JBIR-100 from a newly identified Streptomyces species

Coevolution: Mankind and Microbes

Nafisamycin, Cyclisation Product of a New Enediyne Precursor, Highly Cytotoxic Mansouramycins, Karamomycins Possessing a Novel Heterocyclic Skeleton and Further Unusual Secondary Metabolites from Terrestrial and Marine Bacteria.

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