5‐Hydroxy‐7‐methoxyflavone derivatives from <i>Kaempferia parviflora</i> induce skeletal muscle hypertrophy

Ono, Shintaro; Yoshida, Naoki; Maekawa, Daisuke; Kitakaze, Tomoya; Kobayashi, Yasuyuki; Kitano, Takeshi; Fujita, Takanori; Okuwa-Hayashi, Hirotaka; Harada, Naoki; Nakano, Yoshihisa; Yamaji, Ryoichi

doi:10.1002/fsn3.891

Cited by 17 publications

(9 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In this study, we discovered that the oral administration of DMF inhibited the development of sarcopenia in the aged mice. However, a previous study presented that DMF had no effect on the myotube diameter and the myosin heavy chain (MyHC) expression in the C2C12 myoblasts [36]. These discrepancies can be addressed via several explanations.…”

Section: Discussionmentioning

confidence: 95%

The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways

Kim

Hwang

2020

Nutrients

View full text Add to dashboard Cite

Sarcopenia is a muscle disease featured by the loss of muscle mass and dysfunction with advancing age. The 5,7-dimethoxyflavone (DMF), a major flavone found in Kaempferia parviflora, has biological activities, including anti-diabetes, anti-obesity, and anti-inflammation. However, its anti-sarcopenic effect remains to be elucidated. This current study investigated the inhibitory activity of DMF on sarcopenia. Eighteen-month-old mice were orally administered DMF at the dose of 25 mg·kg−1·day−1 or 50 mg·kg−1·day−1 for 8 weeks. DMF not only stimulated grip strength and exercise endurance but also increased muscle mass and volume. Besides, DMF stimulated the phosphatidylinositol 3-kinase-Akt pathway, consequently activating the mammalian target of rapamycin-eukaryotic initiation factor 4E-binding protein 1-70-kDa ribosomal protein S6 kinase pathway for protein synthesis. DMF reduced the mRNA expression of E3 ubiquitin ligase- and autophagy-lysosomal-related genes involved in proteolysis via the phosphorylation of Forkhead box O3. DMF upregulated peroxisome proliferator-activated receptor-gamma coactivator 1 alpha, nuclear respiratory factor 1, and mitochondrial transcription factor A along with the increase of relative mitochondrial DNA content. DMF alleviated inflammatory responses by reducing the tumor necrosis factor-alpha and interleukin-6 serum and mRNA levels. Collectively, DMF can be used as a natural agent to inhibit sarcopenia via improving protein turnover and mitochondria function.

show abstract

Section: Discussionmentioning

confidence: 95%

The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways

Kim

Hwang

2020

Nutrients

View full text Add to dashboard Cite

show abstract

“…In 35-week-old SAMP1 mice, the mass of skeletal muscles (quadriceps, tibialis anterior, EDL, gastrocnemius, soleus, and plantaris muscles) was lower than that of age-matched SAMR1 mice. At 28 weeks of age, SAMP1 mice showed decreased mass in only the soleus muscles compared with the SAMR1 mice [ 25 ]. These results suggest that in SAMP1 mice, muscle mass was quantitatively affected in slow muscle (e.g., the soleus muscle) rather than in fast muscles (e.g., quadriceps, EDL, gastrocnemius, and plantaris muscles).…”

Section: Discussionmentioning

confidence: 99%

“…Immunofluorescent images were obtained with a BIOREVO BZ-9000 microscope (Keyence, Osaka, Japan). The cross-sectional area (CSA) (µm 2 ) of the muscle fibers was measured as described previously [ 25 ]. The mean fiber CSA was determined from more than 200 fibers per soleus muscle ( n = 6–8 per group).…”

Section: Methodsmentioning

confidence: 99%

β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice

et al. 2020

Self Cite

View full text Add to dashboard Cite

We investigated the effects of β-cryptoxanthin on skeletal muscle atrophy in senescence-accelerated mouse-prone 1 (SAMP1) mice. For 15 weeks, SAMP1 mice were intragastrically administered vehicle or β-cryptoxanthin. At 35 weeks of age, the skeletal muscle mass in SAMP1 mice was reduced compared with that in control senescence-accelerated mouse-resistant 1 (SAMR1) mice. β-cryptoxanthin increased muscle mass with an increase in the size of muscle fibers in the soleus muscle of SAMP1 mice. The expressions of autophagy-related factors such as beclin-1, p62, LC3-I, and LC3-II were increased in the soleus muscle of SAMP1 mice; however, β-cryptoxanthin administration inhibited this increase. Unlike in SAMR1 mice, p62 was punctately distributed throughout the cytosol in the soleus muscle fibers of SAMP1 mice; however, β-cryptoxanthin inhibited this punctate distribution. The cross-sectional area of p62-positive fiber was smaller than that of p62-negative fiber, and the ratio of p62-positive fibers to p62-negative fibers was increased in SAMP1 mice. β-cryptoxanthin decreased this ratio in SAMP1 mice. Furthermore, β-cryptoxanthin decreased the autophagy-related factor expression in murine C2C12 myotube. The autophagy inhibitor bafilomycin A1, but not the proteasome inhibitor MG132, inhibited the β-cryptoxanthin-induced decrease in p62 and LC3-II expressions. These results indicate that β-cryptoxanthin inhibits the p62 accumulation in fibers and improves muscle atrophy in the soleus muscle of SAMP1 mice.

show abstract

“…W trakcie rozwoju postnatalnego liczba włókien mięśniowych nie zwiększa się, natomiast zachodzą procesy przerostu, czyli hipertrofii. Polegają one na zwiększeniu masy i objętości już istniejących włókien mięśniowych (15,41,68).…”

Section: Artykuł Przeglądowy Reviewunclassified

“…W wyniku zwiększenia stężenia IGF-1 w obrębie komórek satelitowych w warunkach in vivo i in vitro dochodzi do uzyskania większych przyrostów tkanki mięśniowej na skutek zwiększenia ilości DNA, jak również syntezy białek charakterystycznych dla włókien mięśniowych (1,37). Hipertoficzny efekt IGF-1 wynika zarówno z pobudzenia proliferacji komórek satelitowych, co powoduje zwiększenie liczby włókien mięśniowych, jak też ze zwiększonej syntezy białek w istniejących włóknach mięśniowych (11,41,65). Domięśniowe podanie czynnika IGF-1 u starszych zwierząt, po urazie mięśni szkieletowych, przyczynia się do pobudzenia proliferacji komórek satelitowych oraz do zwiększenia masy mięśniowej (10).…”

Section: Artykuł Przeglądowy Reviewunclassified

Role of trophic factors in development and regeneration of skeletal muscles

Ciecierska¹,

Sadkowski²,

Motyl³

2019

Medycyna Weterynaryjna

View full text Add to dashboard Cite

The process of skeletal muscle development is regulated by many biologically active factors, which are responsible for stimulating the proliferation and differentiation of muscle cells. Biologically active factors function in paracrine, autocrine and endocrine manner to control myogenesis. The main regulators include hormones, growth and differentiation factors, as well as cytokines. The process of skeletal muscle regeneration associated with the activation of satellite cells for their proliferation and differentiation requires the involvement of many growth factors secreted by the surrounding tissue, including inflammatory cells, blood vessels and damaged muscle fiber, as well as extracellular matrix. A number of trophic factors regulating the activity of satellite cells during muscle regeneration have been identified, e.g. fibroblast growth factors, transforming growth factors-β, insulin-like growth factors, hepatocyte growth factor, tumor necrosis factor-α, interleukin-6. These factors are responsible for maintaining a balance between the processes of proliferation and differentiation of satellite cells in order to restore the proper architecture and functioning of muscle tissue.

show abstract

5‐Hydroxy‐7‐methoxyflavone derivatives from Kaempferia parviflora induce skeletal muscle hypertrophy

Cited by 17 publications

References 32 publications

The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways

The 5,7-Dimethoxyflavone Suppresses Sarcopenia by Regulating Protein Turnover and Mitochondria Biogenesis-Related Pathways

β-Cryptoxanthin Improves p62 Accumulation and Muscle Atrophy in the Soleus Muscle of Senescence-Accelerated Mouse-Prone 1 Mice

Role of trophic factors in development and regeneration of skeletal muscles

Contact Info

Product

Resources

About