5 Immunopathology of primary biliary cirrhosis

Galperin, Cláudio; Gershwin, M. Eric

doi:10.1016/s0950-3528(96)90053-6

Cited by 13 publications

(10 citation statements)

References 71 publications

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“…PBC is an autoimmune liver disease involving inflammatory destruction of intrahepatic bile ducts followed by fibrosis and eventual liver failure [16]. The majority of studies on pathogenesis have focused on mitochondrial antigens and antibodies.…”

Section: Discussionmentioning

confidence: 99%

Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

Wang

Migita

Ito

et al. 2005

Journal of Autoimmunity

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Section: Discussionmentioning

confidence: 99%

Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

Wang

Migita

Ito

et al. 2005

Journal of Autoimmunity

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“…4A,B) was located in the carboxyterminal sequence of SLA/LP overlapping with the sequence that is recognized by antibodies 4, 6. This close proximity of T and B cell epitopes within the SLA/LP autoantigen appears to be a characteristic of autoimmune diseases 12, 20, 21. HLA-DRB1*0301-restricted SLA/LP-specific CD4 + T cells may for example help autoreactive B cells to produce autoantibodies and to secrete proinflammatory cytokines and chemokines that recruit plasma cells and CD8 + T cells into the liver.…”

Section: Discussionmentioning

confidence: 96%

Identification of CD4 T-Cell Epitopes in Soluble Liver Antigen/Liver Pancreas Autoantigen in Autoimmune Hepatitis

et al. 2008

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Background & Aims-Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease associated with autoantibodies and liver-infiltrating lymphocytes. Whereas autoantibodies are routinely tested to diagnose and classify AIH, liver-infiltrating lymphocytes are regarded as the primary factor for disease pathogenesis. The purpose of this study was to identify and characterize autoantigenic peptides within human AIH-specific soluble liver antigen / liver pancreas antigen (SLA/LP) that are targeted by CD4 + T cells and restricted by the disease susceptibility gene HLA-DRB1*0301.

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“…4). 46–49 We have already mentioned the ability of these cells to secrete and respond to cytokines—examples given here are IL-6 and TNF-α 50…”

Section: Immunobiology Of Cholangiocytesmentioning

confidence: 99%

Biology of Cholangiocytes: From Bench to Bedside

2016

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Cholangiocytes, the lining epithelial cells in bile ducts, are an important subset of liver cells. They are activated by endogenous and exogenous stimuli and are involved in the modification of bile volume and composition. They are also involved in damaging and repairing the liver. Cholangiocytes have many functions including bile production. They are also involved in transport processes that regulate the volume and composition of bile. Cholangiocytes undergo proliferation and cell death under a variety of conditions. Cholangiocytes have functional and morphological heterogenecity. The immunobiology of cholangiocytes is important, particularly for understanding biliary disease. Secretion of different proinflammatory mediators, cytokines, and chemokines suggests the major role that cholangiocytes play in inflammatory reactions. Furthermore, paracrine secretion of growth factors and peptides mediates extensive cross-talk with other liver cells, including hepatocytes, stellate cells, stem cells, subepithelial myofibroblasts, endothelial cells, and inflammatory cells. Cholangiopathy refers to a category of chronic liver diseases whose primary disease target is the cholangiocyte. Cholangiopathy usually results in end-stage liver disease requiring liver transplant. We summarize the biology of cholangiocytes and redefine the concept of cholangiopathy. We also discuss the recent progress that has been made in understanding the pathogenesis of cholangiopathy and how such progress has influenced therapy.

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5 Immunopathology of primary biliary cirrhosis

Cited by 13 publications

References 71 publications

Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

Identification of CD4 T-Cell Epitopes in Soluble Liver Antigen/Liver Pancreas Autoantigen in Autoimmune Hepatitis

Biology of Cholangiocytes: From Bench to Bedside

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