Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

Wang, Aiping; Migita, Kiyoshi; Ito, Masahiro; Takii, Yasushi; Daikoku, Manabu; Yokoyama, Terufumi; Komori, Atsumasa; Nakamura, Minoru; Yatsuhashi, Hiroshi; Ishibashi, Hiromi

doi:10.1016/j.jaut.2005.05.003

Cited by 76 publications

(62 citation statements)

References 33 publications

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“…), costimulatory molecules (B7, PD-L1, PD-L2, etc. ), and TLR4, have also been reported in biliary epithelial cells in livers affected by PBC [34][35][36][37][38]. In addition to these molecules involved in innate and acquired immune response, we here demonstrated for the first time that RIG-I/MDA5-MAVS signaling pathway is operative in the strong induction of IFN-b by dsRNA stimulation in HIBECs.…”

Section: Discussionsupporting

confidence: 73%

Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers

et al. 2008

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Section: Discussionsupporting

confidence: 73%

Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers

et al. 2008

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“…Ballot et al [61] reported that 64% of PBC sera were positive for IgM antibodies against lipid A, an immunogenic and toxic component of LPS. TLR4 expression is significantly elevated in biliary epithelial cells and periportal hepatocytes of PBC patients [62]. Monocytes from PBC patients appear more sensitive to the ligand for TLR4 (LPS), producing higher levels of proinflammatory cytokines, particularly IL-1b, IL-6, IL-8, and TNF-a [63].…”

Section: Hepatic Autoimmune Disordersmentioning

confidence: 99%

“…Data regarding expression of TLR4 in cirrhotic patients are conflicting, with studies showing increased expression on BEC, maintained or increased expression on hepatocytes, and maintained or decreased expression on PBMC [62][63][64][69][70][71].…”

Section: Hepatic Fibrosismentioning

confidence: 99%

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

Soares¹,

et al. 2010

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Toll-like receptor 4 (TLR4) is a pattern recognition receptor that functions as lipopolysaccharide (LPS) sensor and whose activation results in the production of several pro-inflammatory, antiviral, and anti-bacterial cytokines. TLR4 is expressed in several cells of healthy liver. Despite the constant confrontation of hepatic TLR4 with gut-derived LPS, the normal liver does not show signs of inflammation due to its low expression of TLR4 and ability to modulate TLR4 signaling. Nevertheless, there is accumulating evidence that altered LPS/TLR4 signaling is a key player in the pathogenesis of many chronic liver diseases (CLD). In this review, we first describe TLR4 structure, ligands, and signaling. Later, we review liver expression of TLR4 and discuss the role of LPS/TLR4 signaling in the pathogenesis of CLD such as alcoholic liver disease, nonalcoholic fatty liver disease, chronic hepatitis C, chronic hepatitis B, primary sclerosing cholangitis, primary biliary cirrhosis, hepatic fibrosis, and hepatocarcinoma.

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“…TLR4 is a receptor for bacterial lipopolysaccharride (LPS) which selectively binds the lipid A portion of LPS. It was also found to be expressed in bile duct epithelial cells and periportal hepatocytes in PBC patient liver tissues [13,14].…”

Section: Introductionmentioning

confidence: 93%

Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis

et al. 2013

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Primary biliary cirrhosis (PBC) is characterized by portal inflammation and immune-mediated destruction of intrahepatic bile ducts that often result in liver failure.Toll-like receptor (TLR) 4 recognizes lipopolysaccharides of Gram-negative bacteria.Infectious agents have been suspected to play a crucial role in PBC pathogenesis since TLR4 expression was found in bile duct epithelial cells and periportal hepatocytes in liver tissues of PBC. To assess the potential contribution of TLR4 SNPs to the development of this disease, we genotyped five SNPs in TLR4 in 261 PBC patients and 359 controls using a TaqMan assay. No significant positive associations with either PBC susceptibility or progression were uncovered. These results indicate that TLR4 polymorphisms do not play a prominent role in the development of PBC in Japanese patients.

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Hepatic expression of toll-like receptor 4 in primary biliary cirrhosis

Cited by 76 publications

References 33 publications

Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers

Increased expression of Toll-like receptor 3 in intrahepatic biliary epithelial cells at sites of ductular reaction in diseased livers

The role of lipopolysaccharide/toll-like receptor 4 signaling in chronic liver diseases

Association analysis of toll-like receptor 4 polymorphisms in Japanese primary biliary cirrhosis

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