5-O-Caffeoylquinic acid: A spectroscopic study and biological screening for antimicrobial activity

Bajko, Ewelina; Kalinowska, Monika; Borowski, Piotr; Siergiejczyk, Leszek; Lewandowski, W.

doi:10.1016/j.lwt.2015.08.024

Cited by 92 publications

(64 citation statements)

References 31 publications

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“…Phenolic acids, flavonoids and alkaloids were the main bioactive compounds identified in Plants. The phenolic acid 5‐O‐caffeoylquinic acid (1551.8 µg/g DM, Table 3) is present in many plants and possesses strong antimicrobial activity (Bajko, Kalinowska, Borowski, Siergiejczyk, & Lewandowski, 2016). The other phenolic acid identified in Plants, methyl 4‐O‐beta‐d‐glucopyranosylcaffeate (2,154.0 µg/g DM), has well‐known antioxidant activity (Braham, Mighri, Jannet, Matthew, & Abreu, 2005).…”

Section: Discussionmentioning

confidence: 99%

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Petrič

Mravčáková

Kucková

et al. 2020

Animal Physiology Nutrition

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The objective of this study was to determine the effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) and dietary substrates containing a mix of the plants on the end products of in vitro ruminal and intestinal fermentation, rumen protozoan population and ruminal antioxidant capacity of sheep. The experiment consisted of fermentations with the four plants used individually as the sole substrate and fermentation of a mix of medicinal plants (Plants): meadow hay:barley grain (MH:B), 700/300 w/w and Plants:MH:B, 100/600/300 w/w/w. The experiment was conducted using the in vitro gas production technique (IVGPT) with 35 ml of buffered inocula and approximately 250 mg (DM basis) of substrate incubated for 24 hr at 39°C in anaerobic conditions. Quantitative analyses of the bioactive compounds by ultra‐high‐resolution mass spectrometry in Plants identified three main groups: flavonoids (22 mg/g DM), phenolic acids (15 mg/g DM) and alkaloids (3 mg/g DM). The total antioxidant capacity (TAC) of the plant extracts and rumen fluid was analysed using a ferric reducing antioxidant power assay. The values of total and individual short‐chain fatty acids, acetate:propionate ratio, pH and total gas production were significantly affected by the single plant substrates and inocula (p < .001). Apart from these parameters, the values of ammonia N, methane production and total gas produced were decreased in Plants:MH:B in comparison with MH:B (p < .001). A positive correlation was recorded between total polyphenols content and TAC of plant extracts (R2 = .778, p < .001). The counts of the total ciliate protozoan population in rumen fluid after 24 hr of fermentation were not significantly different (p > .05). Results suggest that the dietary substrate containing the medicinal plant mix possessed strong ruminal antioxidant capacity, had the potential to reduce methane emission and ammonia concentration and caused desirable changes in the gastrointestinal ecosystem.

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Section: Discussionmentioning

confidence: 99%

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Petrič

Mravčáková

Kucková

et al. 2020

Animal Physiology Nutrition

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“…CGA (5-CQA) was shown to contribute to such activity, with minimum inhibitory effect (MIC) varying in the different studies from 0.8 to 5.0 mg/mL [218,219]. Bactericidal effect was found against the intestinal bacteria Stenotrophomonas maltophilia resistant to trimethoprim/sulfamethoxazole [220], Helicobacter pylori [221], Staphylococcus epidermidis [222], Streptococcus pneumoniae, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella dysenteriae, Salmonella Typhimurium [223], Klebsiella pneumonia [224].…”

Section: Antimicrobial Effectmentioning

confidence: 99%

“…In addition to 5-CQA, bacteriostatic and bactericidal effects of CGA colonic metabolites (ferulic, isoferulic, benzoic, and hydroxybenzoic acids) have been observed against Escherichia coli [225,226]. Minimum inhibitory effect for caffeic acid and other CGA metabolites varied from 0.6 to 80 mg/mL in different studies for different types of microorganisms [221][222][223][224]. The mechanism for antimicrobial action of 5-CQA has been suggested to be binding to the outer cell membrane and disruption of it, exhaustion of intracellular potential, and release of cytoplasm macromolecules, leading to cell death [223].…”

Section: Antimicrobial Effectmentioning

confidence: 99%

Consumption of Chlorogenic Acids through Coffee and Health Implications

2019

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Chlorogenic acids (CGA) are the main antioxidant compounds in the Western diet, due to their high concentrations in coffee associated with the high consumption of the beverage. Until about 10 years ago, like many other phenolic compounds, CGA were thought to be poorly absorbed in the human digestive system. Along the years, large amounts of information on the absorption and metabolism of these compounds have been unveiled, and today, it is known that, on average, about one third of the consumed CGA from coffee is absorbed in the human gastrointestinal tract, although large inter-individual variation exists. Considering results from in vitro animal and human studies, it is possible to conclude that the antioxidant and anti-inflammatory effects of coffee CGA are responsible for, at least to a certain extent, the association between coffee consumption and lower incidence of various degenerative and non-degenerative diseases, in addition to higher longevity.

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“…Nowadays, the commonly observed trend of improving analytical abilities consists in using couplings with more than one separation and detection technique, e.g. LC-UV-MS, LC-MS-MS, LC-NMR-MS, and the like Clifford et al 2005;Deshpande et al 2014;Gu et al 2007;Dai et al 2015;Bajko et al 2016;Tena et al 2015). In the case of plants in which CQAs are present on low concentration levels, and their precise analysis is essential, more integrated and sophisticated systems are applied that couple on-line the process of CQAs extraction with their analysis e.g.…”

Section: Chromatographic Analysismentioning

confidence: 99%

Recent advances in extraction and analysis procedures of natural chlorogenic acids

Wianowska

Gil

2018

Phytochem Rev

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5-O-Caffeoylquinic acid: A spectroscopic study and biological screening for antimicrobial activity

Cited by 92 publications

References 31 publications

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Effect of dry medicinal plants (wormwood, chamomile, fumitory and mallow) on in vitro ruminal antioxidant capacity and fermentation patterns of sheep

Consumption of Chlorogenic Acids through Coffee and Health Implications

Recent advances in extraction and analysis procedures of natural chlorogenic acids

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