2019
DOI: 10.1016/s1470-2045(19)30485-1
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5-year outcome after complete mesocolic excision for right-sided colon cancer: a population-based cohort study

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Cited by 136 publications
(185 citation statements)
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“…6 Bertelsen and colleagues now report the five year outcomes for right colon cancer across the Capital region, demonstrating a significant reduction in recurrence of 9.7% in the CME group vs. 17.9% for non-CME surgery in elective potentially curative stage I-III disease. 7 There is a marked difference in lymph node yield between the CME and non-CME groups (38 vs. 21), often used as a surrogate endpoint of surgical quality. This is unlikely to be explained by central ligation as independent specimen morphometry showed only 11 mm of additional tissue between the bowel wall and high tie with CME surgery.…”
mentioning
confidence: 99%
“…6 Bertelsen and colleagues now report the five year outcomes for right colon cancer across the Capital region, demonstrating a significant reduction in recurrence of 9.7% in the CME group vs. 17.9% for non-CME surgery in elective potentially curative stage I-III disease. 7 There is a marked difference in lymph node yield between the CME and non-CME groups (38 vs. 21), often used as a surrogate endpoint of surgical quality. This is unlikely to be explained by central ligation as independent specimen morphometry showed only 11 mm of additional tissue between the bowel wall and high tie with CME surgery.…”
mentioning
confidence: 99%
“…Crude CS estimates were assessed using the Kaplan‐Meier method. Adjusted 3‐year conditional risk (1 minus CS estimates) stratified by prognostic factors of each endpoint was calculated after adjusting for other covariates using IPW, an algorithm used to balance covariates without sacrificing sample size and statistical power [27–29]; clinicopathological variables (i.e., tumor [T] stage, node [N] stage, EBV DNA, age, sex, histology, smoking, alcohol consumption, family history of NPC, lactate dehydrogenase [LDH], albumin [ALB], C‐reactive protein [CRP] and hemoglobin [HGB]) that were statistically significant in IPW‐adjusted log‐rank tests ( P < 0.050) were considered to be the prognostic factors of the endpoints. Considering that the median follow‐up time of the primary cohort was 67.2 months, we chose the 3‐year conditional risk because it permitted the estimation of conditional risk given existing survival times of 0‐5 years, which has been widely used in studies of CS in other malignancies with similar median follow‐up times [26,30–33].…”
Section: Methodsmentioning
confidence: 99%
“…Absolute standardized difference (ASD) and chi‐square tests were employed to determine the balance of baseline covariates after IPW adjustment. ASD values less than 0.1 indicated negligible imbalance [29,34]. Then, patients were categorized in a competing risk framework according to their first events (i.e., local relapse [LR], regional relapse [RR], bone metastasis [Bone‐M], liver metastasis [Liver‐M], lung metastasis [Lung‐M], NPC‐specific death [NPC‐SD] and other cause‐specific death [OC‐SD]).…”
Section: Methodsmentioning
confidence: 99%
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“…This dissection is not without cost, as overly aggressive clearance of lymphatic tissues around origin vessels on the aorta can not only damage the vessels, but also the nerve plexus resulting in diarrhea, delayed gastric emptying, as well as urologic and sexual dysfunction[ 35 , 36 ]. While several retrospective cohort studies have shown favorable oncologic outcomes, there remains no randomized controlled study to support the benefit of CME at this time, and a recent meta-analysis did not find any significant difference in complications or oncologic outcomes[ 37 - 39 ]. A corollary to CME, sentinel lymph node biopsy (removing the first draining node for a given tumor to determine if additional nodal resection is needed) has been commonly used in many other malignancies, including breast cancer and melanoma; however, in CC in vivo sentinel node biopsy has not been routinely utilized due to technical considerations with the procedure.…”
Section: Surgery For Early Stage Colon Cancermentioning
confidence: 99%