508. Cordycepin, a metabolic product from cultures of Cordyceps militaris(Linn.) link. Part I. Isolation and characterisation

Cunningham, K. G.; Hutchinson, S.A.; Manson, William; Spring, F. S.

doi:10.1039/jr9510002299

Cited by 168 publications

(59 citation statements)

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“…The present study may shed light on the pharmacological basis for the use of CSE to prevent the detrimental effects associated with aging. glutathione; and catalase, which converts H 2 O 2 into molecular oxygen and water (Cunningham et al, 1951). Lipid peroxidation is an autocatalytic process that is a common consequence of cell death.…”

Section: Discussionmentioning

confidence: 99%

“…In Chinese medicine, Cordyceps sinensis has long been used to ameliorate conditions associated with aging and senescence; it is principally applied to treat weakness in the loins and knees, impotence and seminal emission, hyposexuality, fatigue, night sweating and other conditions related to aging. Research shows that Cordyceps sinensis contains crude protein, D-mannitol (Zhang et al, 1991), cordycepin (Cunningham et al, 1951;Kredich and Guarino, 1960) and cordyceps polysaccharide (Miyazaki et al, 1997;Yamada et al, 1984). Recent studies have demonstrated its multiple pharmacological actions, including modulation of immune response (Wu et al, 2006), inhibition of tumor growth (Yoshida et al, 1989;Yoshikawa et al, 2007) and antihypertensive and antiarrhythmic effects (Manabe et al, 1996;Chiou et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Antiaging effect of Cordyceps sinensis extract

Jia

et al. 2008

Phytotherapy Research

104

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This experiment studied the effect of Cordyceps sinensis extract (CSE) on mice aged by D-galactose and castrated rats to analyse its antiaging effect. Water maze and step-down type avoidance tests were used to examine the effect of CSE on learning and memory. CSE shortened escape latency, prolonged step-down latency and decreased the number of errors in mice aged by D-galactose. The effect of CSE on the sexual function of castrated rats was evaluated by measuring the penis erection latency, mount latency and ejaculation latency. CSE appeared to shorten penis erection latency and mount latency in castrated rats. The study also measured the effect of CSE on the activity of age-related enzymes. The results showed that CSE improved the activity of superoxide dismutase, glutathione peroxidase and catalase and lowered the level of lipid peroxidation and monoamine oxidase activity in the aged mice. The study demonstrated that CSE can improve the brain function and antioxidative enzyme activity in mice with D-galactose-induced senescence and promote sexual function in castrated rats. All of these findings suggest that CSE has an antiaging effect.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antiaging effect of Cordyceps sinensis extract

Jia

et al. 2008

Phytotherapy Research

104

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“…The Cordyceps mushroom, Cordyceps sinensis, is the most explored species followed by Cordyceps militaris (1)(2)(3). Recent studies have shown that extract of Cordyceps exhibits antitumor effects on cancers of the bladder, colon, lung, and fibrosarcoma (4), as well as inhibitory effects on the production of inflammatory mediators (5).…”

Section: Introductionmentioning

confidence: 99%

Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells

Noh

Youn²,

Jung³

et al. 2009

Int J Mol Med

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Abstract. Matrix metalloproteinase-9 (MMP-9), which degrades the extracellular matrix (ECM), plays an important role in breast cancer cell invasion. NF-κB and AP-1 are known to induce MMP-9 expression. We investigated whether cordycepin, an NF-κB or AP-1 inhibitor, can modulate MMP-9 expression and cell invasion in MCF-7 cells. Toxicity of cordycepin was determined by 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. MMP-9 expression was determined by real-time PCR, Zymography, and Western blot analysis. AP-1 activation was assayed by electrophoretic mobility shift assay (EMSA). MAPK signaling was evaluated by Western blotting with specific p-ERK, and ERK, p-p38, p38, p-JNK, JNK antibodies. Cordycepin suppressed AP-1 activation, but not NF-κB activation in 12-O-tetradecanoylpho-bol-13-acetate (TPA)-treated MCF-7 cells. Cordycepin inhibits TPA-induced MMP-9 expression and cell invasion by suppressing AP-1 activation. Also, cordycepin suppressed the MAPK signaling pathway. Cordycepin is a potent inhibitor of TPA-induced MMP-9 expression and blocks strongly the ability of AP-1 activation via MAPK signaling pathway in MCF-7 cells.

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“…These include: cordycepin (Cunningham, Herchinson, Manson & Spring, 1951;Kredich & Guarino, 1960) and other antibacterial and antitumor adenosine derivatives (Furuya, Hirotani & Matsuzawa, 1983), ophicordin, an antifungal agent (Kneifel, Srinivasan & Maiti, 1957), a polysaccharide shown to have antitumor activity (Miyazaki, Oikawa & Yamada, 1977;Yamada et al, 1984;Ohmori, Tamura, Tsuru & Nomoto, 1986), an immunopotentiating galactomannan, and L-tryptophan (Zhang, Zhang, Zhu & Chen, 1991). A recent report indicated that the fruiting body of C. sinensis contained growth inhibitors against tumor cells (K562, Vero, Wish, Calu-1 and Raji) other than cordycepin and polysaccharides (Kuo, Ching-Yuang Lin, Wei-Jern Tsai, Wu, Phytochemistry 51 (1999) 891±898 0031-9422/99/$ -see front matter # 1999 Elsevier Science Ltd. All rights reserved.…”

Section: Introductionmentioning

confidence: 99%

Antitumor sterols from the mycelia of Cordyceps sinensis

et al. 1999

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Activity guided fractionations led to the isolation of two antitumor compounds 5a,8a-epidioxy-24(R )-methylcholesta-6,22-dien-3b-D-glucopyranoside and 5,6-epoxy-24(R )-methylcholesta-7,22-dien-3b-ol from the methanol extract of Cordyceps sinensis. Two previously known compounds, ergosteryl-3-O-b-D-glucopyranoside and 22-dihydroergosteryl-3-O-b-D-glucopyranoside were also isolated. The structures of hitherto unknown sterols were established by 1D and 2D NMR spectroscopic techniques with the former synthesized in order to con®rm the identity of the sugar moiety by chemical correlation. The glycosylated form of ergosterol peroxide was found to be a greater inhibitor to the proliferation of K562, Jurkat, WM-1341, HL-60 and RPMI-8226 tumor cell lines by 10 to 40% at 10 mg/ml than its previously identi®ed aglycone, 5a,8a-epidioxy-24(R )-methylcholesta-6,22-dien3b-ol. #

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508. Cordycepin, a metabolic product from cultures of Cordyceps militaris(Linn.) link. Part I. Isolation and characterisation

Cited by 168 publications

References 0 publications

Antiaging effect of Cordyceps sinensis extract

Antiaging effect of Cordyceps sinensis extract

Cordycepin inhibits TPA-induced matrix metalloproteinase-9 expression by suppressing the MAPK/AP-1 pathway in MCF-7 human breast cancer cells

Antitumor sterols from the mycelia of Cordyceps sinensis

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