540 Aspirin desensitization/treatment of aspirin sensitive rhinosinusitic-asthmatic patients: Long term outcomes

Stevenson, D.K.; Hankammer, M.; Mathison, David A.; Christiansen, Sandra C.; Simon, Ronald A.

doi:10.1016/s0091-6749(96)80758-5

Cited by 12 publications

(18 citation statements)

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“…144,145 Four long-term studies of patients who underwent aspirin desensitization followed by daily aspirin ingestion have demonstrated efficacy in reducing upper airway congestion and nasal polyp formation and improving lower airway asthma control. 142,[145][146][147] One study involved 172 patients desensitized between 1995 and 2000 and treated with aspirin, 650 mg twice daily, for 1 to 5 years. 145 Significant reductions in sinus infections and number of rescue oral steroid courses were observed, as well as improvements in anosmia, rhinitis, and asthma symptom scores.…”

Section: Treatment Of the Underlying Respiratory Tract Diseasementioning

confidence: 99%

Clinical and pathologic perspectives on aspirin sensitivity and asthma

Stevenson

Szczeklik

2006

Journal of Allergy and Clinical Immunology

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Aspirin and other nonsteroidal anti-inflammatory drugs that inhibit COX-1 induce unique nonallergic reactions, consisting of attacks of rhinitis and asthma. These hypersensitivity reactions occur in a subset of asthmatic subjects, thus identifying them as having this exclusive clinical presentation. We refer to these patients as having aspirin-exacerbated respiratory disease, a disease process that produces devastating eosinophilic inflammation of both the upper and lower respiratory tracts. This review focuses on a description of patients with aspirin-exacerbated respiratory disease, methods available to diagnose their condition, the unique ability of all nonsteroidal anti-inflammatory drugs that inhibit COX-1 to cross-react with aspirin, an update on pathogenesis, and current thoughts about treatment.

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Section: Treatment Of the Underlying Respiratory Tract Diseasementioning

confidence: 99%

Clinical and pathologic perspectives on aspirin sensitivity and asthma

Stevenson

Szczeklik

2006

Journal of Allergy and Clinical Immunology

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291

258

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“…Once desensitized and maintained with ASA (325 or 650 mg twice daily), patients not only enjoy signifi cant improvement in upper and lower respiratory symptoms but now may safely ingest any of the cross-reacting NSAIDs without suffering respiratory reactions [48]. Four long-term studies of patients who underwent ASA desensitization followed by daily ASA ingestion have demonstrated effi cacy in reducing upper airway congestion and nasal polyp formation and improving lower airway asthma control [47][48][49].…”

Section: Asa Desensitizationmentioning

confidence: 99%

Aspirin sensitivity and desensitization for asthma and sinusitis

Stevenson

2009

Curr Allergy Asthma Rep

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NSAIDs-including aspirin (ASA)-that inhibit cyclooxygenase (COX)-1 induce nonallergic hypersensitivity reactions consisting of attacks of rhinitis and asthma. Such reactions occur exclusively in a subset of asthmatic patients who also have underlying nasal polyps and chronic hyperplastic eosinophilic sinusitis. We now refer to their underlying inflammatory disease of the entire respiratory tract as aspirin-exacerbated respiratory disease. This review focuses on descriptions of these patients; methods available to diagnose ASA-exacerbated respiratory disease; the unique ability of all NSAIDs that inhibit COX-1 to cross-react with ASA; lack of cross-reactivity with selective COX-2 inhibitors; an update on pathogenesis; and current thoughts about treatment, including ASA desensitization and daily ingestion of ASA itself.

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“…6 Five published studies have shown that the majority of patients with AERD experience improvement in their chronic respiratory symptoms after aspirin desensitization treatment. [7][8][9][10][11] In addition to symptomatic relief, the same studies showed that patients with AERD receiving daily aspirin therapy were also able to significantly decrease their doses of systemic corticosteroids or even discontinue this drug.…”

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confidence: 98%