55 P - Intraoperative imprint cytology in the diagnosis of lung tumours

Staniszewski, Andrzej; Marciniak, Marek; Wachacka, B.; Ortowski, T.M.; Kołodziej, Jerzy

doi:10.1016/0959-8049(96)84810-6

Cited by 5 publications

(9 citation statements)

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“…Additionally, based on standardized cytologic criteria, identifying lung cancer type was usually accurate, ranging from 88% PPV in adenocarcinoma to 54% in small cell carcinoma with large cell carcinoma/large cell neuroendocrine carcinoma PPV significantly lower at 38% 13 . Another study by Staniszewski et al 14 aligned with our results and found 84% sensitivity, 94.4% specificity, and 88.1% diagnostic accuracy of intraoperative FNA compared to histological diagnosis. Sugiyama et al 15 also reported 87.7% sensitivity, 100% specificity, 100% PPV, 41.2% NPV, and 88.8% accuracy of intraoperative FNA diagnoses.…”

Section: Discussionsupporting

confidence: 88%

“…The literature has reported the diagnostic accuracy of intraoperative FNA as ranging from 85% to 97%, which is in alignment with our findings of 92% accuracy. 9,10,14,15 In this study, the intraoperative FNA accuracy of differentiating small cell from non-small cell carcinoma is 100%. This observation aligns with results previously reported by Christ et al 16 In our hands, FS was a sensitive (97%) and accurate (97%) diagnostic method, with a NPV of 92%.…”

Section: Discussionmentioning

confidence: 79%

“…adenocarcinoma to 54% in small cell carcinoma with large cell carcinoma/large cell neuroendocrine carcinoma PPV significantly lower at 38%. 13 Another study by Staniszewski et al 14 diagnoses. The literature has reported the diagnostic accuracy of intraoperative FNA as ranging from 85% to 97%, which is in alignment with our findings of 92% accuracy.…”

Section: Discussionmentioning

confidence: 98%

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Diagnostic value of intraoperative fine‐needle aspiration cytologic diagnosis versus frozen section‐based histopathologic diagnosis in thoracic malignancies: A single institution's experience

Mohamed

Donthi

Malik

et al. 2023

Diagnostic Cytopathology

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BackgroundPrimary lung cancer is the leading cause of cancer death in the United States. Most lung cancers are diagnosed in an outpatient setting, but a subset requires intraoperative diagnosis. Two intraoperative diagnostic methods are available, frozen section (FS) and fine needle aspiration (FNA) cytology. This study compares intraoperative FNA cytology and FS based diagnosis in thoracic malignancies within the same clinical practice.MethodsPathology reports from thoracic intraoperative FNA cytology or FS (January 2017–December 2019) were reviewed. Resection diagnosis was the gold standard. If unavailable, concurrent biopsy and final FNA cytology diagnosis were the gold standard.ResultsOf 300 FNA specimens (155 patients), 142 (47%) cases were benign, and 158 (53%) were malignant. Adenocarcinoma was the most common malignant diagnosis (40%), followed by squamous cell carcinoma (26%), neuroendocrine tumors (18%), and other (16%). Intraoperative FNA yielded 88% sensitivity, 99% specificity, and 92% accuracy (p < .001).Of 298 FS specimens (252 patients), 215 (72%) cases were malignant and 83 (28%) were benign. Adenocarcinomas was the most common malignant diagnosis (48%), followed by squamous cell carcinoma (25%), metastatic carcinomas (13%), and other (14%). FS yielded 97% sensitivity, 99% specificity, and 97% accuracy (p < .001).ConclusionOur findings confirm FS is the gold standard for intraoperative diagnosis. FNA cytology may be useful as a non‐invasive, inexpensive initial diagnostic tool intraoperatively, given the similar specificity (99% FNA, 99% FS) and accuracy (92% FNA, 97% FS). Negative FNA could be followed by the costlier and invasive FS. We encourage surgeons to utilize intraoperative FNA first.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 98%

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Diagnostic value of intraoperative fine‐needle aspiration cytologic diagnosis versus frozen section‐based histopathologic diagnosis in thoracic malignancies: A single institution's experience

Mohamed

Donthi

Malik

et al. 2023

Diagnostic Cytopathology

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“…It can be used to give rapid, preliminary diagnosis of lung cancer. [3456789] Bronchial biopsy has also been used as the gold standard diagnostic test to assess the efficacy of other cytologic techniques. [10] Some studies in this topic are present worldwide, but there are only few studies in India, and to the best of our knowledge, none from our state or eastern India.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of imprint smears of bronchoscopic biopsy in lung tumors: A cytohistological correlation

Chowdhury

2019

J Cytol

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Background: There are several methods for obtaining samples in patients of lung tumors, of which bronchoscopic biopsy is the most common. In most of Indian scenario, however, histopathology diagnosis is time taking. Aims and Objectives: To evaluate imprint cytology as a tool for rapid diagnosis of lung carcinoma and its histopathological correlation. Study Type: Prospective study on accuracy of a diagnostic test. Materials and Methods: A total of 175 cases were included in the study, and all of them were subjected to brochoscopic biopsy. Imprint smears were prepared from all the bronchoscopy specimens obtained from 175 cases. Imprint smears were stained with Leishman-Giemsa cocktail and Pap stain, and histopathology sections were stained with hematoxlin and eosin. Histopathological findings were confirmed by immunohistochemistry. Results: Sensitivity and specificity of imprint cytology was 84.9% and 72.4%, respectively when compared to histopathology as standard. Conclusion: Imprint cytology can be used as a preliminary tool for diagnosis in lung tumor bronchoscopic biopsies.

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“…In the case series of thyroid lesions reported by Sakai et al [15] an accuracy of 95.5% was achieved. Staniszewski et al [16,17] have done intraoperative cytology during pulmonary surgery with an accuracy of 84%. Pulmonary cytology and histopathology are valuable tools in the diagnosis of lung malignancies.…”

Section: Introductionmentioning

confidence: 99%

Correlative Study of Imprint and Crush Cytology with Histopathology in Endobronchial Growths

Bhat¹

2013

J Cytol Histol

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This study was undertaken to study the correlation between imprint cytology, crush smears and histopathology in endobronchial growths using fiberoptic bronchoscopy. Methods: The study was conducted in the Department of Internal Medicine and Pathology at Sher-i-Kashmir Institute of Medical Sciences. Eighty-one patients with clinical and radiological evidences of lung lesions were enrolled. From all patients five pieces of tissue were obtained during fiberoptic broncoscopy which revealed an endobronchial growth. From each bit of tissue an imprint and crush smear were prepared by imprinting the tissue on a clean surface of glass slide without compressing the tissue while as crush smear was made by gently crushing the tissue between two glass slides. The tissue specimens were then placed in formaldehyde solution for histological examination. Standard statistical methods were used to analyze the data (chi-square (χ 2) analysis; a Fisher's exact test was used to evaluate the data if more than 25% of the expected values were <5). The level of significance selected was P<0.05. Results: Overall 49 cases (60.49%) were diagnosed as malignant and 31 cases (38.2%) as benign on histopathology. In one case with active bleed, smears were taken from blood clots and bronchoalveolar lavage was done, both of which revealed malignancy. Forty histopathologically proven malignant cases were positive for malignancy (81.6%) on crush smear cytology, while nine cases were not. Imprint smears were positive for malignant cells in 41 cases out of 49 histologically proven malignant cases (83.6%) and eight cases did not show malignant cells on imprint. The sensitivity, specificity, positive predictive value and negative predictive value of crush smear results were 81.6%, 100%, 100% and 77.5% respectively. Conclusion: Imprint and crush cytology are rapid, reliable and accurate techniques. The technique can improve the diagnostic accuracy in endobronchial lesions, as it is faster and more cost effective.

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55 P - Intraoperative imprint cytology in the diagnosis of lung tumours

Cited by 5 publications

References 0 publications

Diagnostic value of intraoperative fine‐needle aspiration cytologic diagnosis versus frozen section‐based histopathologic diagnosis in thoracic malignancies: A single institution's experience

Diagnostic value of intraoperative fine‐needle aspiration cytologic diagnosis versus frozen section‐based histopathologic diagnosis in thoracic malignancies: A single institution's experience

Evaluation of imprint smears of bronchoscopic biopsy in lung tumors: A cytohistological correlation

Correlative Study of Imprint and Crush Cytology with Histopathology in Endobronchial Growths

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