(551) Mindfulness meditation-induced pain relief does not require endogenous opioidergic systems

A, Adler; Wells, Rebecca Erwin; Stagnaro, Emily; Barber, Larissa K.; Porter, Austin; Garcia, Katelyn; Lee, D.; Kaleita, A.; Posey, Grace; Cruikshank, L.; Strittmatter, Brian; Nicolle, M.; Lichstein, Peter R.; Eisenach, J. C.; McHaffie, John G.; Coghill, Robert C.; Zeidan, Fadel

doi:10.1016/j.jpain.2016.01.461

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The proposed findings demonstrate that meditation can be used to immediately reduce evoked pain through non-opioidergic processes. These findings corroborate contemplative text [53] and empirical evidence [12,54,55] indicating that meditation uniquely impacts pain-related affective and comorbid-related outcomes than sensory dimensions of the nociceptive experience. Mindfulness-based mental training was more efficacious at reducing evoked back pain than slow-breathing meditation, indicating that non-reactive reappraisal processes unique to mindfulness-based mental training can produce reliable reductions in radicular chronic pain, a critical finding for the millions of individuals living with chronic pain seeking a fast-acting, userfriendly, and non-opioidergic pain treatment.…”

Section: Discussionsupporting

confidence: 87%

The role of endogenous opioids in mindfulness and sham mindfulness-meditation for the direct alleviation of evoked chronic low back pain: a randomized clinical trial

Khatib,

Dean,

Oliva

et al. 2023

Neuropsychopharmacol.

View full text Add to dashboard Cite

Chronic low back pain (cLBP) is the most prevalent chronic pain condition. There are no treatments that haven been found to directly assuage evoked cLBP. To this extent, mindfulness-meditation is a promising pain therapy. Yet, it is unclear if meditation can be utilized to directly attenuate evoked chronic pain through endogenous opioids. A double-blind, randomized, and placebocontrolled clinical trial with a drug crossover design examined if mindfulness-meditation, as compared to sham mindfulnessmeditation, attenuated straight leg-raise test evoked chronic pain during intravenous (0.15 mg/kg bolus + 0.15 mg/kg/hour maintenance) naloxone (opioid antagonist) and placebo-saline infusion. Fifty-nine individuals with cLBP (mean age = 46 years; 30 females) completed all study procedures. After the pre-intervention pain testing session, patients were randomized to a foursession (20-min/session) mindfulness (n = 30) or sham mindfulness-meditation (n = 29) intervention. After the interventions, mindfulness and sham mindfulness-meditation were associated with significant reductions in back pain during saline and naloxone infusion when compared to rest (non-meditation) in response to the cLBP-evoking straight leg-raise test. These results indicate that meditation directly reduces evoked chronic pain through non-opioidergic processes. Importantly, after the interventions, the mindfulness group reported significantly lower straight leg-raise induced pain than the sham mindfulness-meditation group during rest (non-meditation) and meditation. Mindfulness and sham mindfulness-meditation training was also associated with significantly lower Brief Pain Inventory severity and interference scores. The pain-relieving effects of mindfulness meditation were more pronounced than a robust sham-mindfulness meditation intervention, suggesting that non-reactive appraisal processes may be uniquely associated with improvements in chronic low-back pain.

show abstract

Section: Discussionsupporting

confidence: 87%