55Co-EDTA for renal imaging using positron emission tomography (PET): a feasibility study

Goethals, Patrick; Volkaert, Anneke; Vandewielle, Christof; Dierckx, R. A.; Lameire, Norbert

doi:10.1016/s0969-8051(99)00077-3

Cited by 49 publications

(48 citation statements)

References 8 publications

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“…In that era, authors described 68 Ga-EDTA as having a "low radiation hazard to patient, ease of preparation, constant availability and low cost making this an excellent tracer for clinical imaging" (9). More recently, 55 Co-EDTA has been described in an animal study, but this technique has not been translated to human use and is limited by the requirement for a cyclotron (10). Our group demonstrated the excellent imaging characteristics of 68 Ga-EDTA as part of a high-throughout dynamic small-animal imaging study (11).…”

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confidence: 99%

⁶⁸Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional ⁵¹Cr-EDTA

et al. 2015

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Glomerular filtration rate (GFR) can accurately be determined using 51 Cr-ethylenediaminetetraacetic acid (EDTA) plasma clearance counting but is time-consuming and requires technical skills and equipment not always available in imaging departments. 68 Ga-EDTA can be readily available using an onsite generator, and PET/CT enables both imaging of renal function and accurate camera-based quantitation of clearance of activity from blood and its appearance in the urine. This study aimed to assess agreement between 68 Ga-EDTA GFR ( 68 Ga-GFR) and 51 Cr-EDTA GFR ( 51 Cr-GFR), using serial plasma sampling and PET imaging. Methods: 68 Ga-EDTA and 51 Cr-EDTA were injected concurrently in 31 patients. Dynamic PET/CT encompassing the kidneys was acquired for 10 min followed by 3 sequential 3-min multibed step acquisitions from kidneys to bladder. PET quantification was performed using renal activity at 1-2 min (PET initial ), renal excretion at 2-10 min (PET early ), and, subsequently, urinary excretion into the collecting system and bladder (PET late ). Plasma sampling at 2, 3, and 4 h was performed, with 68 Ga followed by 51 Cr counting after positron decay. The level of agreement for GFR determination was calculated using a Bland-Altman plot and Pearson correlation coefficient (PCC). Results: 51 Cr-GFR ranged from 10 to 220 mL/min (mean, 85 mL/min). There was good agreement between 68 Ga-GFR and 51 Cr-GFR using serial plasma sampling, with a BlandAltman bias of −14 ± 20 mL/min and a PCC of 0.94 (95% confidence interval, 0.88-0.97). Of the 3 methods used for camera-based quantification, the strongest correlation was for plasma sampling-derived GFR with PET late (PCC of 0.90; 95% confidence interval,. Conclusion: 68 Ga-GFR agreed well with 51 Cr-GFR for estimation of GFR using serial plasma counting. PET dynamic imaging provides a method to estimate GFR without plasma sampling, with the additional advantage of enabling renal imaging in a single study. Additional validation in a larger cohort is warranted to further assess utility.

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confidence: 99%

⁶⁸Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional ⁵¹Cr-EDTA

et al. 2015

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“…Due to their availability, blood flow measurement with 82 Rb and 64 Cu-PTSM has a good chance of future clinical application. Glomerular filtration again may accurately be quantified with either 68 Ga-EDTA or 55 Co-EDTA [16]. …”

Section: Current Developmentsmentioning

confidence: 99%

Nuclear Medicine Procedures for the Diagnosis of Acute and Chronic Renal Failure

Haufe

Riedmüller

Haberkorn³

2006

Nephron Clin Pract

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The focus of this review is on the current role of nuclear imaging studies in the clinical evaluation of patients with acute and chronic renal failure. In this setting nuclear imaging has two roles: diagnostic and prognostic, indicating that these methods are an essential component in the evaluation of renal diseases. The functional assessment of the kidney by nuclear medicine procedures is based on the use of radioisotopes bound to non-metabolized molecules with known pharmacokinetics. Renal scintigraphy is usually applied for the assessment of renal function expressed as glomerular filtration rate, effective renal plasma flow or more generally kidney perfusion. Newer methods rely on positron emission tomography, which allows the generation of images with higher resolution and absolute quantitation of biological processes such as transport activities, enzyme activities or angiotensin receptors.

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“…Even if the nuclide is not produced on site, the half-life permits shipment from the production site to the hospital. There are reports in the literature on the use of ionic 55 Co as a potential PET imaging agent in as diverse applications as ischemic stroke [18], multiple sclerosis [19], and imaging of renal function [20]. However, the labeling chemistry of proteins and peptides using the radiometal 55 Co is not well established.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Radiocobalt-Labeled [MMA-DOTA-Cys61]-ZHER2:2395-Cys Affibody Molecule for Targeting of HER2-Expressing Tumors

et al. 2009

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55Co-EDTA for renal imaging using positron emission tomography (PET): a feasibility study

Cited by 49 publications

References 8 publications

⁶⁸Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional ⁵¹Cr-EDTA

⁶⁸Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional ⁵¹Cr-EDTA

Nuclear Medicine Procedures for the Diagnosis of Acute and Chronic Renal Failure

Evaluation of the Radiocobalt-Labeled [MMA-DOTA-Cys61]-ZHER2:2395-Cys Affibody Molecule for Targeting of HER2-Expressing Tumors

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55Co-EDTA for renal imaging using positron emission tomography (PET): a feasibility study

Cited by 49 publications

References 8 publications

68Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional 51Cr-EDTA

68Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional 51Cr-EDTA

Nuclear Medicine Procedures for the Diagnosis of Acute and Chronic Renal Failure

Evaluation of the Radiocobalt-Labeled [MMA-DOTA-Cys61]-ZHER2:2395-Cys Affibody Molecule for Targeting of HER2-Expressing Tumors

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⁶⁸Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional ⁵¹Cr-EDTA

⁶⁸Ga-EDTA PET/CT Imaging and Plasma Clearance for Glomerular Filtration Rate Quantification: Comparison to Conventional ⁵¹Cr-EDTA