6.5 ACUTE Β-Adrenergic BLOCKADE INCREASES AORTIC WAVE REFLECTION IN YOUNG MEN AND WOMEN: DIFFERING MECHANISMS BETWEEN SEXES

Casey, Darren P.; Curry, Timothy B.; Joyner, Michael J.; Charkoudian, Nisha; Barnes, Jill N.; Hart, Emma C J

doi:10.1016/j.artres.2011.10.229

Cited by 11 publications

(14 citation statements)

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“…Previous studies also suggested that AI may be a sensitive index of vascular dysfunction among the young subjects (Aminuddin et al 2014;McEniery et al 2005;McEniery et al 2010). Increased AI may be due to increased ventricular ejection, aortic stiffness or total peripheral resistance (Casey et al 2012). The present finding suggests that AI can be used as an early marker of vascular damage due to CVD risk factor.…”

Section: Discussionmentioning

confidence: 99%

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Aminuddin¹,

Zakaria²,

Chellappan³

et al. 2016

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ABSTRAK Dua petanda kesihatan salur darah baru yang dihasilkan daripada gelombang fotopletismografi jari (PPG) telah diperkenalkan berdasarkan populasi rakyat Malaysia iaitu indeks kecergasan PPG (PPGF) dan indeks jangkaan risiko salur darah (VRPI). Antara objektif kajian ini adalah untuk mengkaji hubungan antara PPGF dengan petanda penyakit jantung (CVD (Beta = 0.35, p < 0.01), p < 0.01), p = 0.04) dan ketinggian (Beta = 0.24, p < 0.01 ABSTRACTTwo new vascular health markers which are derived from finger photoplethysmography (PPG) waveform have been introduced based on Malaysian population, namely PPG fitness index (PPGF) and vascular risk prediction index (VRPI). The objectives of this study were to investigate the associations between PPGF and other cardiovascular disease (CVD) markers such as carotid femoral pulse wave velocity (PWV CF ), to compare PPGF between those with and without CVD risk factors and to determine the sensitivity of VRPI in identifying young subjects with CVD risk factors. A total of 114 men age 20 to 40 yrs with and without CVD risk factors were recruited. Risk factors included hypertension, smoking, dyslipidemia, abdominal obesity and family history of premature CVD. Subjects were divided into healthy, those with one risk factor and those with at least two risk factors. Their weight, height, peripheral and central blood pressure (BP), PWV CF and PPGF were measured and the sensitivity of VRPI in predicting subjects with CVD risk factor was calculated. Data was analyzed via SPSS version 15 and p < 0.05 was considered significant. The mean age of the subjects was 28.94 ± 4.86 yrs. No differences in PPGF was observed between groups (p > 0.05). The independent variables for PPGF were forward pressure (Beta = 0.35, p < 0.01), PWV CF (Beta = -0.26, p < 0.01), systolic BP (Beta = -0.26, p = 0.04) and height (Beta = 0.24, p < 0.01). The sensitivity of VRPI was 82.02%. In conclusion, PPGF was correlated to PWV CF and may be a potential marker of arterial stiffness. In addition, VRPI is sensitive to be used as an early screening of CVD risk factors.

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Section: Discussionmentioning

confidence: 99%

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

Aminuddin¹,

Zakaria²,

Chellappan³

et al. 2016

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“…Following baseline measurements in the supine posture, isoproterenol hydrochloride (Marathon Pharmaceuticals; 1 mg in 500 ml saline) was infused through an intravenous catheter in the left arm at 0.5 g/min (or 15 ml/h) for 1 min, and this infusion rate increased by 0.5 g/min each minute until HR increased by Ն25 beats/min. After a 30-min washout period, a loading dose of propranolol hydrochloride (Hikma Pharmaceuticals) was intravenously infused in the right arm over 15 min (0.25 mg/kg at a rate of 4 ml/min) followed by a maintenance infusion (0.006 mg/kg per min at a rate of 1.45 ml/min) for the remainder of the study, similar to other paradigms (8,49). Pulmonary function was measured in the left lateral position before the start of propranolol infusion and after the loading dose of propranolol to ensure that ␤-AR blockade did not influence lung function (34).…”

Section: Ethical Approvalmentioning

confidence: 99%

β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men

Ross

Gao

Pollock

et al. 2014

American Journal of Physiology-Heart and Circulatory Physiology

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Patients with coronary artery disease have attenuated coronary vasodilator responses to physiological stress, which is partially attributed to a β-adrenergic receptor (β-AR)-mediated mechanisms. Whether β-ARs contribute to impaired coronary vasodilation seen with healthy aging is unknown. The purpose of this study was to investigate the role of β-ARs in coronary exercise hyperemia in healthy humans. Six young men (26 ± 1 yr) and seven older men (67 ± 4 yr) performed isometric handgrip exercise at 30% maximal voluntary contraction for 2 min after receiving intravenous propranolol, a β-AR antagonist, and no treatment. Isoproterenol, a β-AR agonist, was infused to confirm the β-AR blockade. Blood pressure and heart rate were monitored continuously, and coronary blood flow velocity (CBV, left anterior descending artery) was measured by transthoracic Doppler echocardiography. Older men had an attenuated ΔCBV to isometric exercise (3.8 ± 1.3 vs. 9.7 ± 2.1 cm/s, P = 0.02) compared with young men. Propranolol decreased the ΔCBV at peak handgrip exercise in young men (9.7 ± 2.1 vs. 2.7 ± 0.9 cm/s, P = 0.008). However, propranolol had no effect on ΔCBV in older men (3.8 ± 1.3 vs. 4.2 ± 1.9 cm/s, P = 0.9). Older men also had attenuated coronary hyperemia to low-dose isoproterenol. These data indicate that β-AR control of coronary blood flow is impaired in healthy older men.

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“…Previous studies have shown that response to acute beta adrenergic blockade may differ according to sex. Studies have shown that peripheral vascular beta adrenergic sensitivity is enhanced in women, compared with men [12,19]. Accordingly, we analysed our data according to sex and found no significant difference between the two groups in terms of aortic pulse pressure and aortic SBP reduction.…”

Section: Effects Of Bisoprolol and Atenolol On Central Haemodynamicsmentioning

confidence: 64%

“…Prolonged beta blockade, especially with nonselective beta blockers, may increase systemic vascular resistance due to reduction of beta 2 mediated vasodilation and/or unopposed alpha-mediated vasoconstriction [12,13]. In a study by Kampus et al [14], vasodilating beta blocker nebivolol, compared with metoprolol, was associated with significant reduction in central SBP and CPP despite similar reduction in brachial blood pressure and heart rate.…”

Section: Effects Of Bisoprolol and Atenolol On Central Haemodynamicsmentioning

confidence: 97%

A prospective, randomized, open-label, active-controlled, clinical trial to assess central haemodynamic effects of bisoprolol and atenolol in hypertensive patients

Park

Rhee²,

Lee

et al. 2013

Journal of Hypertension

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6.5 ACUTE Β-Adrenergic BLOCKADE INCREASES AORTIC WAVE REFLECTION IN YOUNG MEN AND WOMEN: DIFFERING MECHANISMS BETWEEN SEXES

Cited by 11 publications

References 0 publications

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

The Assessment of Finger Photoplethysmography Fitness Index (PPGF) among Young Men with Cardiovascular Disease Risk Factors: A Cross Sectional Study

β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men

A prospective, randomized, open-label, active-controlled, clinical trial to assess central haemodynamic effects of bisoprolol and atenolol in hypertensive patients

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