6-Aminopyridine-3-boronic acid functionalized magnetic nanoparticles for highly efficient enrichment of cis-diol-containing biomolecules

Abstract

Boronate affinity materials, as efficient sorbents for extraction, separation and enrichment of cis-diol-containing biomolecules, have attracted more and more attention in recent years. However, conventional boronate affinity materials require a...

Functionalized cryogel monoliths for fast and selective separation of nucleic acids directly from crude lysate

“…However, it becomes hydroxylated and converts into tetrahedral geometry in a basic medium that is ready to form the cyclic bond with cis‐diol groups. Again, under acidic conditions, the hydrolysis of cyclic ester takes place and gives boronate the trigonal geometry (Ektirici et al, 2021; Li & Dong, 2021). Previously, boronate‐based interaction has been successfully employed for separation of nucleic acid precursors like nucleosides, nucleotides, and RNA from the mixture of RNA and DNA (Çiçek, 2005; Elmas et al, 2004).…”

Optimized Glycopeptide Enrichment Method–It Is All About the Sauce

“…While some experiments yielded high glycoproteomic coverage, they did require prefractionation to achieve this. 6 − 9 …”

“…There are many method papers that describe novel chemistries and approaches for the use of boronic acids for glycopeptide enrichment. While some experiments yielded high glycoproteomic coverage, they did require prefractionation to achieve this. − …”

Highly efficient separation and enrichment of polyphenols by 6-aminopyridine-3-boronic acid-functionalized magnetic nanoparticles assisted by polyethylenimine

“…And 3-carboxybenzoboroxole require difficult preparation while 6-aminopyridine-3-boronic acid is commercially available. 40 Thus, it is necessary to develop PEI-assisted 6-aminopyridine-3-boronic acid functionalized MNPs in order to address the issues of 3-carboxybenzoboroxole. Although 6-aminopyridine-3-boronic acid had been used as affinity ligands to prepare boronic acid functionalized MNPs, 40 PEI was not applied in this reference, which would affect the binding properties to some extent.…”

“… 40 Thus, it is necessary to develop PEI-assisted 6-aminopyridine-3-boronic acid functionalized MNPs in order to address the issues of 3-carboxybenzoboroxole. Although 6-aminopyridine-3-boronic acid had been used as affinity ligands to prepare boronic acid functionalized MNPs, 40 PEI was not applied in this reference, which would affect the binding properties to some extent. In addition, this is first report on boronic acid functionalized materials using polyphenols as the research targets.…”