6‐phosphogluconate Dehydrogenase (6pgd) Activity in the Vaginal Fluid in Benign and Malignant Gynaecological Lesions

Muir, G. G.; Canti, G.

doi:10.1111/j.1471-0528.1966.tb15541.x

Cited by 10 publications

(2 citation statements)

References 17 publications

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“…Freeze drying caused a considerable loss of phosphohexose isomerase activity. 6-phosphogluconate dehydrogenase supported such a concept (Muir and Canti, 1966 (Muir, 1966) and would thus be a more sensitive indicator of gynaecological inflammatory lesions. It was hoped that phosphohexose isomerase might thus act as an initial screening test for detecting gynaecological lesions, amongst which would be carcinoma of the cervix.…”

Section: Resultsmentioning

confidence: 81%

“…In a previous paper (Muir, 1966), the possibility of using phosphohexose isomerase as a screen test for cervical carcinoma in situ and invasive carcinoma was suggested. It was felt that the activity of this enzyme in the vaginal fluid might provide a means of selecting those cases which were more likely to have cervical carcinoma, and therefore the number of smears needing examination would be considerably reduced.…”

mentioning

confidence: 99%

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A trial of phosphohexose isomerase as a means of detecting cervical carcinoma

Muir

Valteris

1968

J Clin Pathol

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Section: Resultsmentioning

confidence: 81%

mentioning

confidence: 99%

A trial of phosphohexose isomerase as a means of detecting cervical carcinoma

Muir

Valteris

1968

J Clin Pathol

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Distribution of enzymes in human vaginal fluid.Relevance to the Diagnosis of Cervical Cancer

Goldberg

Hart

Watts

1968

Cancer

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Pooled material obtained by vaginal irrigation of women with gynecologic conditions has been fractionated into cellular and extracellular phases to determine the best method of applying enzyme assays in the diagnosis of cancer of the cervix uteri. Ribonuclease, when measured in the homogenized cellular material, was elevated by more than 400% in the group with cancer. Estimations utilizing the extracellular plasma and high speed supernatants prepared from the homogenate were unpromising. β‐glucuronidase was increased in the homogenate seven‐fold. With few exceptions, no activity could be detected in supernatants derived from the nonmalignant group whereas activity was found in all supernatants derived from the group with cancer. The plasma fraction showed considerable overlap between the two groups although the group with cancer had a much higher mean value. Phosphogluconate dehydrogenase was invariably present in the plasma and supernatant fractions of patients with cancer and almost always absent from the nonmalignant group.

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