6 Robustness of in vitro percutaneous absorption studies - an international evaluation

Sandt, J.J.M. van de; Maas, Wilfred; Burgsteden, Johan A. van; Sartorelli, Patrı́cia; Montomoli, L; Larese, F; Payan, Jean-Paul; Limasset, J. C.; Carmichael, Paul L.; Kenyon, S.J.; Robinson, Eve; Dick, Ian P; Nielsen, Julius; Schaller, K. H.; Korinth, Gintautas; Geh, Stefan; Cage, Stephen A; Williams, FM

doi:10.1016/s0378-4274(03)90005-1

Cited by 3 publications

(2 citation statements)

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“…1a). The obtained permeation fluxes (J) also resulted in agreement with previously published data obtained with CAF aqueous solutions [20], suggesting that both formulations did not alter the CAF permeation profile. On the contrary, the J value was significantly increased when viscous gel-like structure was used as vehicle (Table 2).…”

Section: In Vitro Human Skin Permeation Studysupporting

confidence: 88%

Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product?

Musazzi

Franzè

Minghetti

et al. 2017

Drug Deliv. and Transl. Res.

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The use of nanoemulsions in cosmetic products has been enlarged in the last decades because of several formulative advantages (e.g., the improved self-life stability, better texture properties). In addition, nanoemulsions seemed to improve the penetration of active ingredients through the human skin, comparing to conventional emulsion. In this contest, the risk of a higher systemic exposure of consumer to active ingredients, due to the ability of nanoemulsion to enhance permeation, results a critical attribute that should be evaluated for assuring the consumer safety. The aim of this work was the evaluation of how an oil-in-water (O/W) nanoemulsion can influence the in vitro skin permeation profiles of two model active ingredients with different polarity (i.e., caffeine and ethyl ximenynate). Preliminarily, since both selected molecules influenced the physical stability of nanoemulsion, formulative studies were carried out to identify the most stable formulation to perform in vitro permeation studies. The overall results demonstrated that nanoemulsions could significantly influence the permeation profiles of molecules as a function of their physicochemical properties. In particular, O/W nanoemulsions significantly improved the permeation profiles of apolar active ingredients in comparison to conventional emulsions, whereas no differences were observable for polar molecules. Considering such findings, it is worth observing that there is room for reconsidering the risk assessment of nanoemulsion-based cosmetic products.

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Section: In Vitro Human Skin Permeation Studysupporting

confidence: 88%

Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product?

Musazzi

Franzè

Minghetti

et al. 2017

Drug Deliv. and Transl. Res.

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“…The most percutaneous absorption data of chemicals is obtained in diffusion cell experiments. There exist guidelines (23) and detailed consensus protocols (24) for such studies. Human in vivo and diffusion cell studies cannot be performed applying the same experimental conditions, although comparison studies between both methods are possible (25)(26)(27)(28)(29).…”

Section: Methods For the Assessment Of Percutaneous Absorptionmentioning

confidence: 99%

Percutaneous absorption of aromatic amines and the risk assessment resulting from the dermal pathway

Korinth¹

2013

Front Biosci

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Aromatic amines (AA) are compounds of different carcinogenic potency causing occupational bladder cancer. The percutaneous absorption of AA is mostly appraised to be high. Many AA are, therefore, assigned with skin notations. However, for the assessment of the dermal exposure route only little data are available. Additionally, in many studies the skin penetration data for AA are provided as absorbed percentage of applied dose or permeability coefficients, which are less useful in risk assessment. In this overview, the toxicological relevance of percutaneous absorption of AA was evaluated and a percutaneous penetration ranking for some AA is proposed. A continuous skin exposure of hands to AA for a few minutes can exceed the inhalative exposure over 8 hours at occupational threshold limit values in the workplace air. The health risk resulting from the percutaneous absorption of AA can be considerable. Also the dermal exposure to azo dyes, which can be metabolized to AA, should be considered with caution.

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The Devil is in the Detail…

Moss

Gullick²,

Wilkinson

2015

Predictive Methods in Percutaneous Absorption

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6 Robustness of in vitro percutaneous absorption studies - an international evaluation

Cited by 3 publications

References 0 publications

Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product?

Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product?

Percutaneous absorption of aromatic amines and the risk assessment resulting from the dermal pathway

The Devil is in the Detail…

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