Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product?

Musazzi, Umberto M.; Franzè, Silvia; Minghetti, Paola; Casiraghi, Antonella

doi:10.1007/s13346-017-0390-7

Cited by 35 publications

(16 citation statements)

References 21 publications

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“…Light scattering on nanoscale colloidal systems causes a characteristic bluish reflection called the Tyndall Effect and represents a parameter indicative of the kinetic stability acquired by nano-emulsions compared to macroemulsions [ 44 ]. However, nano-emulsion are susceptible to flocculation, coalescence and sedimentation instabilities [ 45 ].…”

Section: Resultsmentioning

confidence: 99%

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

et al. 2021

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Ayapana triplinervis is a plant species used in traditional medicine and in mystical-religious rituals by traditional communities in the Amazon. The aim of this study are to develop a nano-emulsion containing essential oil from A. triplinervis morphotypes, to evaluate larvicidal activity against Aedes aegypti and acute oral toxicity in Swiss albino mice (Mus musculus). The essential oils were extracted by steam dragging, identified by gas chromatography coupled to mass spectrometry, and nano-emulsions were prepared using the low energy method. Phytochemical analyses indicated the major compounds, expressed as area percentage, β-Caryophyllene (45.93%) and Thymohydroquinone Dimethyl Ether (32.93%) in morphotype A; and Thymohydroquinone Dimethyl Ether (84.53%) was found in morphotype B. Morphotype A essential oil nano-emulsion showed a particle size of 101.400 ± 0.971 nm (polydispersity index = 0.124 ± 0.009 and zeta potential = -19.300 ± 0.787 mV). Morphotype B essential oil nano-emulsion had a particle size of 104.567 ± 0.416 nm (polydispersity index = 0.168 ± 0.016 and zeta potential = -27.700 ± 1.307 mV). Histomorphological analyses showed the presence of inflammatory cells in the liver of animals treated with morphotype A essential oil nano-emulsion (MAEON) and morphotype B essential oil nano-emulsion (MBEON). Congestion and the presence of transudate with leukocyte infiltration in the lung of animals treated with MAEON were observed. The nano-emulsions containing essential oils of A. triplinervis morphotypes showed an effective nanobiotechnological product in the chemical control of A. aegypti larvae with minimal toxicological action for non-target mammals.

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Section: Resultsmentioning

confidence: 99%

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

et al. 2021

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“…The human epidermis membrane used for in vitro permeation studies was obtained from the abdominal skin of a single donor. The epidermis was prepared according to the heat separation method, as previously reported [33].…”

Section: Methodsmentioning

confidence: 99%

Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases

et al. 2019

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Psoriasis is a chronic cutaneous condition characterized by the release of pro-inflammatory mediators and oxidative stress. The reduction of these factors is currently the most effective strategy to inhibit the symptoms of pathology. Antioxidants from natural sources are increasingly used to improve skin conditions. Dried red leaves from grapevine (Vitis vinifera L., cv Teinturiers) showed anti-inflammatory and anti-bacterial activities, but their possible effects on keratinocytes have not been previously investigated. In this study we tested the ability of a water extract from grapevine leaves (VVWE) to inhibit inflammatory conditions in human keratinocytes (HaCaT cells), challenged with proinflammatory (tumor necrosis factor-α (TNF-α) or lipopolysaccharide (LPS)) or prooxidant (ultraviolet B radiation (UVB) or H2O2) mediators. VVWE inhibited interleukin-8 (IL-8) secretion induced by proinflammatory stimuli, acting on the IL-8 promoter activity, but the effect was lower when prooxidant mediators were used. The effect was partly explained by the reduction of nuclear factor-κB (NF-κB)-driven transcription and nuclear translocation. Furthermore, vascular endothelial growth factor (VEGF) secretion, a regulator of angiogenesis, was inhibited by VVWE, but not matrix metalloproteinase-9 (MMP-9), a protease involved in matrix remodeling. VVWE, assayed on Franz diffusion cell system, showed a marked reduction of High Performance Liquid Chromatography (HPLC)-identified compounds. Pure molecules individually failed to reduce TNF-α-induced IL-8 release, suggesting synergistic effects or the presence of other bioactive compounds still unknown.

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“…The authors observed comparable permeation in both emulsion and nanoemulsion forms of caffeine. Retention was higher (though not significantly different) in the caffeine emulsion (Musazzi et al 2018). In a separate study, Shakeel and Ramadan observed that caffeine nanoemulsion exhibited a better in vitro skin permeation profile compared with caffeine aqueous solution (Shakeel and Ramadan 2010).…”

Section: Alkaloidsmentioning

confidence: 80%

Current developments in the nanomediated delivery of photoprotective phytochemicals

Kumar

Jose

2020

Environ Sci Pollut Res

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Natural products have been used to protect the skin from harmful UV radiation for decades. Due to the ecotoxicological implications of synthetic sunscreen exposure in aquatic ecosystems, there is a greater need to explore alternative sources of UV filters. Recent research has focused on discovering novel UV absorbing photoprotective molecules from nature. In response to the excessive damage caused by UVB rays, plants induce the production of high concentrations of phytoprotective secondary metabolites and anti-oxidative enzymes. Despite promising UV absorbing and photoprotective properties, plant secondary metabolites have been underutilized in topical delivery due to low solubility and high instability. Numerous phytochemicals have been effectively nanosized, incorporated in formulations, and studied for their sustained effects in photoprotection. The present review outlines recent developments in nanosizing and delivering photoprotective crude plant extract and phytochemicals from a phytochemical perspective. We searched for articles using keywords: "UV damage," "skin photoprotection," "photodamage," and "nano delivery" in varied combinations. We identified and reviewed literature from 43 original research articles exploring nanosized phytochemicals and crude plant extracts with photoprotective activity. Nanosized phytochemicals retained higher amounts of bioactive compounds in the skin and acted as depots for their sustained release. Novel approaches in nanosizing considerably improved the photostability, efficacy, and water resistance of plant secondary metabolites. We further discuss the need for broad-spectrum sunscreen products, potential challenges, and future growth in this area.

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Emulsion versus nanoemulsion: how much is the formulative shift critical for a cosmetic product?

Cited by 35 publications

References 21 publications

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

Development of nano-emulsions based on Ayapana triplinervis essential oil for the control of Aedes aegypti larvae

Vitis vinifera L. Leaf Extract Inhibits In Vitro Mediators of Inflammation and Oxidative Stress Involved in Inflammatory-Based Skin Diseases

Current developments in the nanomediated delivery of photoprotective phytochemicals

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